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梁維哲 博士

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    資料來源:臨床醫學研究科       

    最高學歷: 高雄國立中山大學生物科學(系)所 博士畢業

     

    學術經歷:

    1. 高雄榮民總醫院教學研究部 高級助理研究員 (2020/03迄今)
    2. 大仁科技大學藥學系暨製藥科技研究所 兼任副教授 (2019/09/01迄今)
    3. 東洋藥品工業股份有限公司 約聘研究員 (2013/04至2018/01)

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    1. 教育部頒定副教授 (副字第146791號)
    2. TOEIC高級檢定證照 (證書字號10503726)
    3. 經濟部智慧財產局之智慧財產培訓學院結業證書 (智培智基證字第00023號; 智培檢索證字第00017號)
    4. 財團法人國家衛生研究院毒理學家認證課程證書
    5. 成功大學生技藥物之開發管理培訓證書
    6. 台灣毒理學學會永久會員 (2017迄今)
    7. 經濟部智慧財產局之智慧財產培訓學院永久會員 (2017迄今)
    1. 毒理醫學
    2. 環境毒物
    3. 氧化壓力
    4. 毒殺路徑
    1. 期刊論文

    單獨第一作者或通訊作者: #第一作者 *通訊作者 (近五年發表論文)

    1. Hsu SS, Jan CR, Liang WZ*. Uncovering malathion (an organophosphate insecticide) action on Ca2+ signal transduction and investigating the effects of BAPTA-AM (a cell-permeant Ca2+ chelator) on protective responses in glial cells. Pestic Biochem Physiol 2019 Jun;157:152-60 (IF: 2.751; Entomology ranking: 8/98)

    2. Shieh P, Jan CR, Liang WZ*. The protective effects of the antioxidant N-acetylcysteine (NAC) against oxidative stress-associated apoptosis evoked by the organophosphorus insecticide malathion in normal human astrocytes. Toxicology 2019 Apr;417:1-14 (IF: 4.099; Toxicology ranking: 23/93)

    3. Hsu SS, Jan CR, Liang WZ*. The investigation of the pyrethroid insecticide lambda-cyhalothrin (LCT)-affected Ca2+ homeostasis and -activated Ca2+-associated mitochondrial apoptotic pathway in normal human astrocytes: the evaluation of protective effects of BAPTA-AM (a selective Ca2+ chelator). Neurotoxicology 2018 Dec;69:97-107 (IF: 3.105; Toxicology ranking: 32/93)

    4. Hsu SS, Jan CR, Liang WZ*. Evaluation of cytotoxicity of propofol and its related mechanism in glioblastoma cells and astrocytes. Environ Toxicol 2017 Dec;32(12):2440-54 (IF: 3.118; Water Resources: 24/91)

    5. Liang WZ#, Jan CR, Hsu SS. Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation. Food Chem Toxicol 2017 Sep;107(Pt A):280-92 (IF: 4.679; Food Science & Technology ranking: 22/135)

    6. Liang WZ#, Chou CT, Cheng JS, Wang JL, Chang HT, Chen IS, Lu T, Yeh JH, Kuo DH, Shieh P, Chen FA, Kuo CC, Jan CR. The effect of the phenol compound ellagic acid on Ca2+ homeostasis and cytotoxicity in liver cells. Eur J Pharmacol 2016 Jun;780:243-51 (IF: 3.263; Pharmacology & Pharmacy ranking: 91/267)

    7. Hsu SS, Chou CT, Liao WC, Shieh P, Kuo DH, Kuo CC, Jan CR, Liang WZ*. The effect of gallic acid on cytotoxicity, Ca2+ homeostasis and ROS production in DBTRG-05MG human glioblastoma cells and CTX TNA2 rat astrocytes. Chem Biol Interact 2016 May;252:61-73 (IF: 3.723; Toxicology ranking: 30/93)

     

    共同第一作者或通訊作者: #第一作者 *通訊作者 (近五年發表論文)

    1. Sun GC, Jan CR, Liang WZ*. Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells. Environ Toxicol 2020 Mar;35(3):395-403 (IF: 3.118; Water Resources: 21/94) (共同通訊作者)
    2. Sun GC, Liang WZ*, Jan CR. Mechanisms underlying the effect of an oral antihyperglycemic agent glyburide on calcium ion (Ca2+) movement and its related cytotoxicity in prostate cancer cells. Clin Exp Pharmacol Physiol 2020 Jan;47(1):111-8 (IF: 2.456; Physiology ranking: 41/81) (共同通訊作者)
    3. Chien JM, Liang WZ#, Liao WC, Kuo CC, Chou CT, Hao LJ, Jan CR. Ca2+ movement and cytotoxicity induced by the pyrethroid pesticide bifenthrin in human prostate cancer cells. Hum Exp Toxicol 2019 Oct;38(10);1145-54 (IF: 2.067; Toxicology ranking: 71/92) (共同第一作者)
    4. Cheng HH, Liang WZ#, Kuo CC, Hao LJ, Chou CT, Jan CR. The exploration of effect of terfenadine on Ca2+ signaling in renal tubular cells. J Recept Signal Transduct Res 2019 Jun;39(1):73-9 (IF: 1.466; Biochemistry & Molecular Biology ranking: 261/297) (共同第一作者)
    5. Sun GC, Chen HH, Liang WZ*, Jan CR. Exploration of the effect of the alkaloid colchicine on Ca2+ handling and its related physiology in human oral cancer cells. Arch Oral Biol 2019 Jun;102:179-85 (IF: 1.931; Dentistry, Oral Surgery & Medicine ranking: 37/91) (共同通訊作者)
    6. Wang JL, Chou CT, Liang WZ#, Wu CJ, Kuo CC, Hao LJ, Shieh P, Jan CR. Effects of timolol on Ca2+ handling and viability in human prostate cancer cells. Toxicol Mech Methods 2019 Feb;29(2):138-45 (IF: 2.295; Toxicology ranking: 62/92) (共同第一作者)
    7. Hsieh SF, Chou CT, Liang WZ#, Kuo CC, Wang JL, Hao LJ, Jan CR. The effect of magnolol on Ca2+ homeostasis and its related physiology in human oral cancer cells. Arch Oral Biol 2018 May;89:49-54 (IF: 1.931; Dentistry, Oral Surgery & Medicine ranking: 37/91) (共同第一作者)
    8. Lu T, Chou CT, Liang WZ#, Kuo CC, Chen IL, Wang JL, Jan CR. Amitriptyline modulated Ca2+ signaling and induced Ca2+-independent cell viability in human osteosarcoma cells. Hum Exp Toxicol 2018 Feb;37(2):125-34 (IF: 2.067; Toxicology ranking: 71/92) (共同第一作者)
    9. Fang YC, Chou CT, Liang WZ#, Kuo CC, Hsu SS, Wang JL, Jan CR. Effect of tetramethylpyrazine (TMP) on Ca2+ signal transduction and cell viability in a model of renal tubular cells. J Biochem Mol Toxicol 2017 Oct;31(10):e21952 (IF: 3.606; Toxicology ranking: 19/92) (共同第一作者)
    10. Cheng HH, Chou CT, Liang WZ#, Kuo CC, Shieh P, Wang JL, Jan CR. Effects of puerarin on intracellular Ca2+ and cell viability of MDCK renal tubular cells. Environ Toxicol Pharmacol 2017 Jun;52:83-9 (IF: 3.292; Toxicology ranking: 30/92) (共同第一作者)
    11. Su CK, Chou CT, Lin KL, Liang WZ#, Cheng JS, Chang HT, Chen IS, Lu T, Kuo CC, Yu CC, Shieh P, Kuo DH, Chen FA, Jan CR. Effect of protriptyline on [Ca2+]i and viability in MG63 human osteosarcoma cells. Toxicol Mech Methods 2016 Oct;26(8):580-7 (IF: 2.295; Toxicology ranking: 62/92) (共同第一作者)
    1. 研討會論文

    1. Yen HC, Liang WZ*. (2019/04/27-28) Action of propofol on Ca2+ mobilization and its related physiology in OC2 human oral cancer cells. (麻醉劑異丙酚在人類口腔癌細胞的鈣離子移動和細胞生理的效應)。第11屆亞太醫學檢驗科學國際研討會 (The 11th Asian-Pacific Forum of Medical Laboratory Sciences, Taichung, Taiwan)。

    2. Yen HC, Liang WZ*. (2019/03/24-25) Evaluation of the organophosphate insecticide malathion action on Ca2+ homeostasis and cell viability in normal human astocytes. (評估有機磷殺蟲劑馬拉硫磷在人類正常星狀細胞的鈣離子恆定和細胞存活率的效應)。34屆生物醫學聯合學術年會 (The 34th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan)。

    3. Hsu SS, Liang WZ*. (2018/03/24-25) Antioxidant and protective effects of N-acetylcysteine on malathion-induced oxidative stress and cytotoxicity in human astrocytes. (抗氧化劑乙醯半胱氨酸對殺蟲劑馬拉硫磷在人類正常星狀細胞誘發的氧化壓力和細胞毒殺的保護機制)。33屆生物醫學聯合學術年會 (The 33th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan)。

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