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陳信宏 博士

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    心腎症候群調控實驗室研究員 
    陳信宏 (Hsin-Hung Chen)

    現職:

    高雄榮民總醫院 教學研究部 高級助理研究員 (2020/10迄今) 

    經歷:

    高雄榮民總醫院 教學研究部 高級助理研究員 (2020/10 ~ 迄今)

    教育部頒定助理教授 (助字第146595號) (2018/06/01~)

    高雄榮民總醫院 教學研究部 博士後研究員 (2016/12 ~ 2020/07)

    育英醫護管理專科學校 兼任助理教授 (2017/02 ~ 迄今)

    育英醫護管理專科學校 兼任講師 (2015/09 ~ 2017/01)

    秀傳醫療財團法人 彰濱秀傳紀念醫院 檢驗師 (2006/12 ~ 2008/02)

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    高血壓發生在超過80％的慢性腎臟病(CKD)患者中，其發生心血管疾病的風險高於一般人群。CKD與心血管疾病發病率和死亡率增加有關，這種關聯進一步支持腎-心連接的概念。第4型的心腎症候群(CRS)特徵在於原發性CKD，導致心臟功能受損，左心室肥大(LVH），舒張功能障礙和/或不良心血管事件風險增加。我們研究發現，給予GABA促進劑治療或腎神經剔除可以改善GABA功能，恢復感壓反射，降低血壓，進一步改善心腎症候群。

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    中樞心臟血管研究

    高血壓模式探討

    心腎症候群機制探討

    心臟代謝症候群機制探討

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    1. 轉譯醫學

    2. 高血壓  

    3. 中樞心臟血管

    4. 腎臟系統疾病

    1. Society for Neuroscience, U.S.A.

    2. American Physiological Society, U.S.A.

    3. Chinese Physiological Society

    4. Taiwan Pharmacological Society-Taipei

    (A)期刊論文

    1. Lu WH, Chen HH, Chen BH, Lee JC, Lai CC, Li CH, Tseng CJ*. Norepinephrine Leads to More Cardiopulmonary Toxicities than Epinephrine by Catecholamine Overdose in Rats. Toxics, 2020 Sep 16;8(3):E69. doi: 10.3390/toxics8030069. IF: 3.271, SC: 92/265, ENVIRONMENTAL SCIENCES, 34.72%
    2. Ho CY, Lin YT, Chen HH, HO WY, Sun GC, Hsiao M, Lu PJ, Cheng PW, Tseng CJ*. CX3CR1- microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats. Journal of Neuroinflammation, 2020 June 12; 17:185. doi: 10.1186/s12974-020-01857-7. IF: 5.793; SC: 36/271, Neurosciences, 13.3%
    3. Chen HH, Li YD, Cheng PW, Fang YC, Lai CC, Tseng CJ, Pan JY*, Yeh TC*. Gabapentin Reduces Blood Pressure and Heart Rate through the Nucleus Tractus Solitarii. Acta Cardiol Sin, 2019 Nov 14;35:627-633. doi: 10.6515/ACS.201911_35(6).20190429B. IF: 1.676; SC: 99/136, CARDIAC & CARDIOVASCULAR SYSTEMS, 72.79%
    4. Chen HH, Chu CH, Wen SW, Lai CC, Cheng PW, Tseng CJ*. Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients, 2019 Oct 25;11(11). pii: E2581. doi: 10.3390/nu11112581. IF: 4.171; SC: 16/87, NUTRITION & DIETETICS, 18.39%
    5. Wu CJ, Chen HH, Cheng PW, Lu WH, Tseng CJ, Lai CC*. Outcome of robot assisted bilateral internal mammary artery grafting via left pleura in coronary bypass surgery. Journal of Clinical Medicine, 2019 Apr 12;8(4). pii: E502. doi: 10.3390/jcm8040502. IF: 5.583; SC: 15/154, MEDICINE, GENERAL & INTERNAL, 9.74%
    6. Lin CH, Yen CC, Hsu YT, Chen HH, Cheng PW, Tseng CJ, Lo YK, Chan JYH*. Baroreceptor Sensitivity Predicts Functional Outcome and Complications after Acute Ischemic Stroke. Journal of Clinical Medicine, 2019 Mar 3;8(3). pii: E300. doi: 10.3390/jcm8030300. IF: 5.583; SC: 15/154, MEDICINE, GENERAL & INTERNAL, 9.74%
    7. Chen HH, Yeh TC, Cheng PW, Ho WY, HO CY, Lai CC, Sun GC, Tseng CJ*. Antihypertensive potential of Coenzyme Q10 via free radical scavenging and enhanced Akt-nNOS signaling in the nucleus tractus solitarii in rats. Molecular Nutrition & Food Research, 2019 Mar; 63(6): e1801042. (Cover story) doi: 10.1002/ mnfr.201801042. IF: 5.151; 5/133, FOOD SCIENCE & TECHNOLOGY, 3.76%
    8. Lin YT, Wu YC, Sun GC, Ho CY, Wong TY, Lin CH, Chen HH, Yeh TC, Li CJ, Tseng CJ, Cheng PW*. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer's Disease. Journal of Clinical Medicine, 2018 Oct 5;7(10). pii: E329. doi: 10.3390/jcm7100329. IF: 5.583; SC: 15/154, MEDICINE, GENERAL & INTERNAL, 9.74%
    9. Yeh TC, Shin CS, Chen HH, Lai CC, Sun GC, Tseng CJ, Cheng PW*. Resveratrol Regulates Blood Pressure by Enhancing AMPK Signaling to Downregulate a Rac1-Derived NADPH Oxidase in the Central Nervous System. Journal of Applied Physiology, 2018 Jul 1;125(1): 40-48. doi:10.1152/ japplphysiol.00686. 2017. IF: 3.256; SC: 11/81, SPORT SCIENCES, 13.58%
    10. Lin CH, Hsu YT, Yen CC, Chen HH, Tseng CJ, Lo YK, Chan JYH*. Association between heavy metal levels and acute ischemic stroke. Journal of Biomedical Science, 2018 May 25;25(1):49. doi: 10.1186/s12929-018-0446-0. IF: 3.466; 46/133, MEDICINE, RESEARCH & EXPERIMENTAL, 34.59%
    11. Lin CH, Pan JY, Chang JJ, Chen HH, Cheng PW, Tseng CJ*. Involvement of Endothelial Nitric Oxide Synthase Activation in Midkine-Mediated Central Hypotensive Effects. The Chinese Journal of Physiology, 2017 Dec 31;60(6):353-362. DOI: 10.4077/CJP.2017.BAG512. IF: 0.827; SC: 75/83, PHYSIOLOGY, 90.36%
    12. Cheng PW, Lin YT, Ho WY, Lu PJ, Chen HH, Lai CC, Sun GC, Yeh TC, Hsiao M, Tseng CJ, Liu CP*. Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance. Free Radic Biol Med. 2017 Nov; 112:298-307. doi: 10.1016/j.freeradbiomed.2017.07.022. IF: 6.020; 17/143, ENDOCRINOLOGY & METABOLISM, 11.88%
    13. Chen HH, Cheng PW, Ho WY, Lu PJ, Lai CC, Tseng YM, Fang HC, Sun GC, Hsiao M, Liu CP, Tseng CJ*. Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension. Scientific Reports, 2016 Dec 5; 6: 38447. doi: 10.1038/srep38447. IF: 4.122; SC: 12/64, MULTIDISCIPLINARY SCIENCES, 18.75%
    14. Cheng PW, Lee HC, Lu PJ, Chen HH, Lai CC, Sun GC, Yeh TC, Hsiao M, Lin YT, Liu CP, Tseng CJ*. Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension. Scientific Reports, 2016 May 3; 6: 25342. doi: 10.1038/srep25342. IF: 4.122; SC: 12/64, MULTIDISCIPLINARY SCIENCES, 18.75%
    15. Cheng PW, Chen YY, Cheng WH, Lu PJ, Chen HH, Chen BR, Yeh TC, Sun GC, Hsiao M, Tseng CJ*. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling. Diabetes, 2015 Oct; 64(10): 3413-24. doi: 10.2337/db14-1439. IF: 7.273; SC: 10/143, ENDOCRINOLOGY & METABOLISM, 6.99%
    16. Chen HH, Lu PJ, Chen BR, Hsiao M, Ho WY, Tseng CJ*. Heme Oxygenase-1 Ameliorates Kidney Ischemia-reperfusion Injury in Mice through Extracellular Signal-regulated Kinase 1/2-Enhanced Tubular Epithelium Proliferation. Biochimica Et Biophysica Acta-Molecular Basis Of Disease, 2015 Oct; 1852(10 Pt A):2195-201. doi: 10.1016/j.bbadis.2015.07.018. IF: 5.108; SC: 9/72, BIOPHYSICS, 12.5%
    17. Cheng PW, Kang BH, Lu PJ, Lin SS, Ho WY, Chen HH, Hong LZ, Wu YS, Hsiao M, Tseng CJ*. Involvement of Two Distinct Signalling Pathways in IGF-1-Mediated Central Control of Hypotensive Effects in Normotensive and Hypertensive Rats. Acta Physiologica, 2014 Sep; 212(1): 28-38. doi: 10.1111/apha.12340. IF: 5.930; SC: 5/83, PHYSIOLOGY, 6.02%

     

    (B)研討會論文:

    1. Chen HH, Cheng PW, Tseng CJ*. Glut5-KD reduces blood pressure via increases phosphorylation of nNOS and decreases NADPH oxidase by AMPK activation in the NTS of fructose-induced hypertensive rats. Experimental Biology Annual Meeting 2019. Orlando, FL, USA. Apr. 06~09, 2019.
    2. Chen HH, Cheng PW, Tseng CJ*. Fructose intake impairs baroreflex sensitivity in the early stage of fructose-induced hypertension through central nervous system regulation in rats. 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan. July 1~6, 2018.
    3. Chen HH, Tseng CJ*. Fructose-induced neurogenic hypertension is mediated by superoxide overexpression and stimulates p38 MAPK-induced central insulin resistance in the central nervous system. Experimental Biology Annual Meeting 2017. Chicago, IL, USA. Apr. 22~26, 2017.
    4. Chen HH, Cheng PW, Tseng CJ*. Renal Denervation Improves Baroreflex and GABA System Normalization in Chronic Kidney Disease-associated Hypertension. Experimental Biology Annual Meeting 2016. San Diego, CA, USA. Apr. 2~6, 2016.
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