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鄭珮妏

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    聯絡人：唐維       資料來源：醫學研究科       聯絡資訊：twei@vghks.gov.tw       

    *: corresponding author

     

    1. Yeh TC, Wu YC, Wong TY, Sun GC, Tseng CJ, Cheng PW*. Dapagliflozin prevents ERK activation and SGLT2-dependent endoglin upregulation in a mechanically provoked cardiac injury model. Physiol Rep. 2024 Apr;12(7):e15990. doi: 10.14814/phy2.15990. (IF: 2.5；PHYSIOLOGY 43/83)
    2. Ho CY, Sun GC, Lin YT, Wong TY, Hsiao M, Tseng CJ, Cheng PW*. Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats. Eur J Pharmacol. 2024 Jan 5;962:176171. (IF: 5.0; PHARMACOLOGY & PHARMACY 59/278)
    3. Chen, YY.; Chen CK; Wu, TT.; Ho, CY.; Yeh, TC.; Sun, GC.; Tseng, CJ.; Cheng, PW*. Attenuation of epithelial-mesenchymal transition via SGLT2 inhibition and diabetic cataract suppression by dapagliflozin nanoparticles treatment. Life Science. 2023 Oct 1;330:122005. (IF: 6.1; PHARMACOLOGY & PHARMACY 35/277) 
    4. Lin HL*, Tseng YH*, Cheng PW, Hao CL, Tu YC, Yeh BC, Shen KP. Content Analysis of Chenopodium formosanum (Djulis) Collected from Two Production Areas and Evaluation of Their Ability to Improve Insulin Resistance. Natural Product Communications. 2023 18(6); 1-9. (IF: 1.59; CHEMISTRY, MEDICINAL 59/63)
    5. Lin ZI, Tsai TH, Yu KC, Nien YH, Liu RP, Liu GL, Chi PL, Fang YP, Ko BT, Law WC, Zhou C, Yong KT, Cheng PW*, Chen CK*. Creation of chitosan-based nanocapsulc-in-nanofiber structures for hydrophobic/hydrophilic drug co-delivery and their dressing applications in diabetic wounds. Macromolecular Bioscience 2023, 2300145 (IF: 4.6; Polymer Science 18/86)
    6. Chen, YY.; Wu, TT.; Ho, CY.; Yeh, TC.; Sun, GC.; Tseng, CJ.; Cheng, PW*. Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus. Int. J. Mol. Sci. 2022, 23, 7142. https://doi.org/10.3390/ijms23137142(IF: 6.208; Biochemistry & Molecular Biology 69/296) 
    7. Cheng PW, Liang HL, Lin HL, Hao CL, Tseng YH, Tu YC, Yeh BC, Shen KP. Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat. J. Clin. Biochem. Nutr. 2022; 70(3):1-8. (IF: 3.179; NUTRITION & DIETETICS 61/90)
    8. Cheng PW, Wu YC, Wong TY, Sun GC, Tseng CJ. Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3β-Tau Complex to Impair Insulin Signaling Transduction. Biomedicines. 2021; 9(11):1650. (IF: 4.757; PHARMACOLOGY & PHARMACY 86/279)
    9. Sun GC, Tse J, Hsu YH, Ho CY, Tseng CJ, Cheng PW*. μ-Opioid Receptor-Mediated AT1R–TLR4 Crosstalk Promotes Microglial Activation to Modulate Blood Pressure Control in the Central Nervous System. Antioxidants. 2021; 10(11):1784. (IF: 7.0; CHEMISTRY, MEDICINAL 6/60)
    10. Cheng PW, Tsai PJ, Tai MH, Bee YS. Therapeutic Effect of α-MSH in Primary Cultured Orbital Fibroblasts Obtained from Patients with Thyroid Eye Disease. International Journal of Molecular Sciences. 2021; 22(20):11225. (IF: 6.208; Biochemistry & Molecular Biology 69/296)
    11. Wu TT, Chen YY, Ho CY, Yeh TC, Sun GC, Tseng CJ, Cheng PW*. H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus. Antioxidants 2021, 10(7), 1086.  (IF: 7.0; CHEMISTRY, MEDICINAL 6/60)
    12. Lin HL, Cheng PW, Tu YC, Yeh BC, Wu BN, Shen KP. The effectiveness comparisons of eugenosedin-A, glibenclamide and pioglitazone on diabetes mellitus induced by STZ/NA and high-fat diet in SHR. J Pharm Pharmacol. 2021 Mar 29; rgab029. (IF: 4.810; Pharmacology& Pharmacy 82/279)
    13. Liang HL, Cheng PW, Lin HL, Hao CL, Ke LY, Chou HY, Tseng YH, Yen HW, Shen KP. Extract of pre-germinated brown rice protects against cardiovascular dysfunction by reducing levels of inflammation and free radicals in a rat model of type II diabetes. Journal of Functional Foods. 2020 Oct. 75: 104218. (IF: 5.223; Food Science & Technology 37/143)
    14. Ho CY, Lin YT, Chen HH, Ho WY, Sun GC, Hsiao M, Lu PJ, Cheng PW*, Tseng CJ*. CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats. J Neuroinflammation. 2020 Jun 12;17(1):185. (IF: 9.3; Neurosciences 20/272)
    15. Wu TT, Chen YY, Chang HY, Kung YH, Tseng CJ, Cheng PW*. AKR1B1-Induced Epithelial–Mesenchymal Transition Mediated by RAGE-Oxidative Stress in Diabetic Cataract Lens. Antioxidants 2020 Mar 25;9(4):273. pii: E273. MOST108-2320-B-075B-002. (IF: 7.0; CHEMISTRY, MEDICINAL 6/60)
    16. Lai CC, Juang WC, Sun GC, Tseng YK, Jhong RC, Tseng CJ, Wong TY, Cheng PW*. Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells. Int. J. Mol. Sci. 2020, 21, 2196. (IF: 6.208; Biochemistry & Molecular Biology 69/296)  
    17. Sun GC, Wong TY, Chen HH, Ho CY, Yeh TC, Ho WY, Tseng CJ, Cheng PW*. Angiotensin II Inhibits DDAH1-nNOS Signalling via AT1R and μOR Dimerization to Modulate Blood Pressure Control in the Central Nervous System. Clin Sci (Lond). 2019 Dec 12;133(23):2401-2413. doi: 10.1042/CS20191005 (IF: 6.0; Medicine, Research&Experimental 34/136)
    18. Chen HH, Chu CH, Wen SW, Lai CC, Cheng PW*, Tseng CJ.  Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients 2019, 11(11), 2581. MOST (IF: 6.706; Nutrition & Dietetics 15/90)
    19. Chen YY, Wu TT, Ho CY, Yeh TC, Sun GC, Kung YH, Wong TY,  Tseng CJ, Cheng PW*. Dapagliflozin Prevents NOX-and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2019 Sep 5;20(18). pii: E4357. doi: 10.3390/ijms20184357. (IF: 6.208; Biochemistry & Molecular Biology 69/296)
    20. Wong TY, Chang SN, Jhong RC, Tseng CJ, Sun GC, Cheng PW*. Closer to Nature Through Dynamic Culture Systems. Cells 2019, 8(9), 942; doi.:10.3390/cells8090942. (IF: 7.666; Cell Biology 51/194) 
    21. Chen HH*, Yeh TC*, Cheng PW, Ho WY, Ho CY, Lai CC, Sun GC, Tseng CJ. Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt-nNOS Signaling in the Nucleus Tractus Solitarii in Rats. Mol Nutr Food Res. 2019 Mar;63(6):e1801042. doi: 10.1002/mnfr.201801042.  (IF: 6.575; FOOD SCIENCE & TECHNOLOGY 21/143)

    研討會論文

    1. Pei-Wen Cheng, Ying-Ying Chen. Induction of Epithelial-Mesenchymal Transition by SGLT2 reduction in diabetic cataract development and progression via dapagliflozin nanoparticles. Investigative Ophthalmology & Visual Science, June 2023, Vol.64, 1223.
    2. Pei-Wen Cheng, Yu-Te Lin, Yi-Chung Wu, Tzyy-Yue Wong. Recapitulating GSK3β and Tau interaction in brain injury dynamic model. The FASEB Journal, April 2020; Journal 34(S1):1-1
    3. Tsung-Tien Wu, Ying-Ying Chen, Pei-Wen Cheng. AKR1B1-Induced epithelial-mesenchymal transision Mediated by RAGE- Oxidative Stress in the Lens of DM Cataracts. The FASEB Journal, April 2020; Journal 34(S1):1-1
    4. Pei-Wen Cheng, Gwo-Ching Sun, Ching-Jiunn Tseng. Angiotensin II Inhibits DDAH1-nNOS Signaling through AT1R and μOR Dimerization in the Central Nervous System to Modulate Central Control of Blood Pressure. The FASEB Journal, 2019;Vol. 33, No. 1 Supplement 872.4.
    5. Gwo-Ching Sun, Yi-Chung Wu, Ching-Jiunn Tseng, Pei-Wen Cheng. Resveratrol Decrease of Reactive Oxygen Species-Derived Cognitive Impairment in Angiotensin II Induced Rat Model of Early Alzheimer’s disease. 18th World Congress of Basic and Clinical Pharmacology. Jul 2, 2018. 
    6. Chen YY; Wu TT; Cheng PW*. Dapagliflozin Decrease Fructose-Induced Oxidative Stress Mediated by NADPH Oxidase via a SGLT-2-Dependent Mechanism in the Lens of Type 2 DM Model. Investigative Ophthalmology & Visual Science, 2017, Vol.58, 3176. (IF=3.3； R/C=11/59, Ophthalmology).
    7. Hsin-Hung Chen, Pei-Wen Cheng and Ching-Jiunn Tseng (2017, Apr). Fructose induced neurogenic hypertension is mediated by superoxide overexpression and stimulates p38 MAPK-induced central insulin resistance in the central nervous system. The FASEB Journal, vol. 31 no. 1 Supplement 883.3.
    8. Ching-Jiunn Tseng and Pei-Wen Cheng (2015, Apr). Involvement of Two Distinct Signalling Pathways in IGF-1-Mediated Central Control of Hypotensive Effects in Normotensive and Hypertensive Rats. The FASEB Journal, vol. 29 no. 1 Supplement 624.2. (SCI, 7/86, BIOLOGY).
    9. Pei-Wen Cheng, Ching-Jiunn Tseng (2014, Aug). Inhibition of Rac1-derived reactive oxygen species by AMPK decreases blood pressure in a fructose-induced rat model of hypertension. JOURNAL OF NEUROCHEMISTRY, 130(suppl 1), 46-46. (SCI, 56/252, NEUROSCIENCES).

    專書

    Tseng C.J., Cheng P.W., Tung C.S.. Pharmacology of the Nucleus Tractus Solitarii. PRIMER ON THE AUTONOMIC NERVOUS SYSTEM. Third Edition CH029 (3) (ISBN: 978-0-12-386525-0). San Diego, USA: Elsevier Academic Press. Nov, 2011.  

    專利研發

    1. 【中文發明名稱】奈米眼藥水及其製造方法 (發明第I756547號)
    2. 【中文發明名稱】醫藥組成物及其製備方法與纖維複合材料 (發明第 823807 號)

     

     

     

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