高雄榮民總醫院教學研究部

學歷：

1. 博士 高雄醫學大學藥學院 天然藥物研究所 (2003/09至2008/07)
2. 碩士高雄醫學大學基礎醫學研究所 (2001/09至2003/07)

學術經歷：

高雄榮民總醫院教學研究部副研究員 (2019/10迄今)

高雄榮民總醫院教學研究部高級助理研究員 (2017/09至2019/10)

國立中山大學生物醫學研究所合聘副教授 (2019/02迄今)

國立中山大學生物醫學研究所合聘助理教授 (2018/09至2019/01)

育英護理專科學校護理系兼任助理教授 (2017/09迄今)

樹人護理專科學校物理治療系兼任助理教授 (2017/09至2019/02)

高雄榮民總醫院教學研究部助理研究員 (2016/09至2017/09)

國防醫學院藥學系兼任助理教授 (2013/09至2014/09)

高雄榮民總醫院教學研究部心臟血管研究室博士後研究 (2009/09至2016/09)

加拿大戴爾豪斯大學醫學院微生物免疫學部博士後研究 (2008/09至2009/07)

1.      Young Investigator Awardees, 第七屆亞太生理學聯盟學術大會(FAOPS 2011)

2.      科技部博士後研究人員學術著作獎, 2015

3.      杜聰明博士年輕學者獎, 2015

1. Society for Neuroscience, U.S.A.

2. American Society for Pharmacology and Experimental Therapeutics, ASPET, U.S.A.

3. Taiwan Pharmacological Society-Taipei

4. Chinese Physiological Society

1. 藥物之開發: 退化性疾病、代謝性症候群、白內障
2. 代謝性症候群
3. 白內障機制
4. 退化性疾病

*: corresponding author

1. Ho CY, Lin YT, Chen HH, Ho WY, Sun GC, Hsiao M, Lu PJ, Cheng PW*, Tseng CJ*. CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats. J Neuroinflammation. 2020 Jun 12;17(1):185. (IF: 5.793; Neurosciences 36/271)
2. Wu TT, Chen YY, Chang HY, Kung YH, Tseng CJ, Cheng PW*. AKR1B1-Induced Epithelial–Mesenchymal Transition Mediated by RAGE-Oxidative Stress in Diabetic Cataract Lens. Antioxidants (Basel). 2020 Mar 25;9(4):273. (IF: 5.014; Food Sciences & Technology 10/139) MOST108-2320-B-075B-002.
3. Lai CC, Juang WC, Sun GC, Tseng YK, Jhong RC, Tseng CJ, Wong TY, Cheng PW*. Vitamin D Attenuates Loss of Endothelial Biomarker Expression in Cardio-Endothelial Cells. Int J Mol Sci. 2020 Mar 22;21(6):2196. (IF: 4.556; Biochemistry & Molecular Biology 74/297) MOST108-2320-B-075B-002.
4. Sun GC, Wong TY, Chen HH, Ho CY, Yeh TC, Ho WY, Tseng CJ, Cheng PW*. Angiotensin II Inhibits DDAH1-nNOS Signalling via AT1R and μOR Dimerization to Modulate Blood Pressure Control in the Central Nervous System. Clin Sci (Lond). 2019 Dec 12;133(23):2401-2413. (IF: 5.223; Medicine, Research & Experimental 24/138) 
5. Chen HH, Chu CH, Wen SW, Lai CC, Cheng PW*, Tseng CJ. Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients. 2019 Oct 25;11(11):2581. (IF: 4.546; Nutrition & Dietetics 17/89) 
6. Chen YY, Wu TT, Ho CY, Yeh TC, Sun GC, Kung YH, Wong TY,  Tseng CJ, Cheng PW *. Dapagliflozin Prevents NOX-and SGLT2-Dependent  Oxidative

26.  Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2019 Sep 5;20(18):4357. (IF: 4.556; Biochemistry & Molecular Biology 74/297) 

7. Wong TY, Chang SN, Jhong RC, Tseng CJ, Sun GC, Cheng PW*. Closer to Nature Through Dynamic Culture Systems. Cells. 2019 Aug 21;8(9):942. (IF: 4.366; Cell Biology 70/195) 
8. Chen HH*, Yeh TC*, Cheng PW, Ho WY, Ho CY, Lai CC, Sun GC, Tseng CJ. Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt-nNOS Signaling in the Nucleus Tractus Solitarii in Rats. Mol Nutr Food Res. 2019 Mar;63(6):e1801042. (IF: 5.309; Food Science & Technology 8/139) 
9. Wong TY, Juang WC, Tsai CT, Tseng CJ, Lee WH, Chang SN, Cheng PW*. Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1. J Clin Med. 2018 Nov 2;7(11):410. (IF: 3.303; Medicine, General & Internal 36/165) 
10. Lin YT, Wu YC, Sun GC, Ho CY, Wong TY, Lin CH, Chen HH, Yeh TC, Li CJ, Tseng CJ, Cheng PW*. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer's Disease. J Clin Med. 2018 Oct 5;7(10):329. (IF: 3.303; Medicine, General & Internal 36/165) 
11. Wu MY, Yiang GT, Liao WT, Tsai PY, Chen YL, Cheng PW, Li CY, Li CJ. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018;46(4):1650-1667. (IF: 5.500; Physiology: 8/83.) 
12. Yeh TC, Shin CS, Chen HH, Lai CC, Sun GC, Tseng CJ, and Cheng PW*. Resveratrol Regulates Blood Pressure by Enhancing AMPK Signaling to Downregulate a Rac1-Derived NADPH Oxidase in the Central Nervous System. J Appl Physiol (1985). 2018 Jul 1;125(1):40-48. (IF: 3.044; Sport Sciences 18/85)
13. Cheng PW, Lin YT, Ho WY, Lu PJ,  Chen HH, Lai C C, Sun GC, Yeh TC, Hsiao M, Tseng CJ; Liu CP.  Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance. Free Radic Biol Med. 2017 Nov;112:298-307. (IF: 6.170; Endocrinology & Metabolism 16/143)
14. Chen YY; Wu TT; Cheng PW*. Dapagliflozin Decrease Fructose-Induced Oxidative Stress Mediated by NADPH Oxidase via a SGLT-2-Dependent Mechanism in the Lens of Type 2 DM Model. Investigative Ophthalmology & Visual Science. 2017, Vol.58, 3176. (IF: 3.470; Ophthalmology 10/60)
15. Juang WC, Huang SJ, Huang FD, Cheng PW*, Wann SR. Application of time series analysis in modelling and forecasting emergency department visits in a medical centre in Southern Taiwan. BMJ Open. 2017 Dec 1;7(11):e018628. (IF: 2.496; Medicine, General & Internal 52/165)
16. Cheng PW, Lee HC, Lu PJ, Chen HH, Lai CC, Sun GC, Yeh TC, Hsiao M, Lin YT, Liu CP, Tseng CJ. Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension. Sci Rep. 2016 May 3;6:25342. (IF: 3.998; Multidisciplinary Sciences 17/71)
17. Lai CC, Liu CP, Cheng PW, Lu PJ, Hsiao M, Lu WH, Sun GC, Liou JC, Tseng CJ. Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. Crit Care Med. 2016 Sep;44(9):e866-74. (IF: 7.414; Critical Care Medicine 5/36)
18. Cheng PW, Chen YY, Cheng WH, Lu PJ, Chen HH, Chen BR, Yeh TC, Sun GC, Hsiao M, Tseng CJ. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes. 2015 Oct;64(10):3413-24. (IF: 7.720; Endocrinology & Metabolism 9/143)
19. Sun G.C., Ho W.Y., Chen B.R., Cheng P.W., Cheng W.H., Hsu M.C., Yeh T.C., Hsiao M, Lu P.J., Tseng C.J. GPCR dimerization in brainstem nuclei contributes to the development of hypertension. Br J Pharmacol. 2015 May;172(10):2507-18. (IF: 7.730; Pharmacology & Pharmacy 9/270)
20. Cheng PW, Kang B.H., Lu P.J., Lin S.S., Ho W.Y., Chen H.H., Hong L.Z., Wu Y.S. , Hsiao M., Tseng C.J. Involvement of Two Distinct Signalling Pathways in IGF-1-Mediated Central Control of Hypotensive Effects in Normotensive and Hypertensive Rats. Acta Physiol (Oxf). 2014 Sep;212(1):28-38. (IF: 5.542; Physiology 8/81)
21. Cheng PW, Ho WY, Su YT, Lu PJ, Chen BZ, Cheng WH, Lu WH, Sun GC, Yeh TC, Hsiao M, Tseng CJ. Resveratrol decrease fructose-induced oxidative stress mediated by nadph oxidase via an ampk-dependent mechanism. Br J Pharmacol. 2014 Jun;171(11):2739-50. (IF: 7.730; Pharmacology & Pharmacy 9/270)
22. Yeh T.C., Liu C.P., Cheng W.H., Chen B.R., Lu P.J., Cheng P.W., Ho W.Y., Sun G.C., Liou J.C., Tseng C.J. Caffeine Intake Improves Fructose-Induced Hypertension and Insulin Resistance by Enhancing Central Insulin Signaling. Hypertension. 2014 Mar;63(3):535-41. (IF: 7.713; Peripheral Vascular Disease 4/65)
23. Lu W.H., Lu P.J., Wu Y.S., Ho W.Y., Cheng P.W., Lai C.C., Hsiao M, Wang J.S., Tseng CJ. Different Impacts of Alpha and Beta Blockers in Neurogenic Hypertension Produced by Brainstem Lesions in Rat. Anesthesiology. 2014 May;120(5):1192-204. (IF: 7.067; Anesthesiology 1/32)
24. Cheng W.H., Ho W.Y., Chang C.F., Lu .PJ., Cheng P.W., Yeh T.C., Hong L.Z., Sun G.C., Hsiao M, Tseng C.J. Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation. Br J Pharmacol. 2013 Oct;170(4):847-58. (IF: 7.730; Pharmacology & Pharmacy 9/270)
25. Cheng W.H., Lu P.J., Hsiao M, Hsiao C.H., Ho W.Y., Cheng P.W., Lin C.T., Hong L.Z., Tseng C.J. Renin Activates PI3K-Akt-eNOS Signaling Through the AT1 Receptor and Mas Receptor to Modulate Central Blood Pressure Control in the Nucleus Tractus Solitarii. Br J Pharmacol. 2012 Aug;166(7):2024-35.  (IF: 7.730; Pharmacology & Pharmacy 9/270)
26. Cheng P.W., Wu Alexander T. H., Lu P.J., Yang Y.C., Ho W.Y., Lin H.C., H. Michael, and Tseng C.J. Modulation of Central Control of Central hypotensive effects of neuropeptide Y are modulated by endothelial nitric oxide synthase after activation by ribosomal protein S6 kinase. Br J Pharmacol. 2012 Nov;167(5):1148-60. (IF: 7.730; Pharmacology & Pharmacy 9/270)
27. Hong L.Z.*, Cheng P.W.*, Cheng W. H., Chen S.R., Wang L.L., Tseng C.J. Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects. Chin J Physiol. 2012 Oct 31;55(5):337-45. (IF: 1.151; Physiology 72/81)

研討會論文

1. Pei-Wen Cheng, Gwo-Ching Sun, Ching-Jiunn Tseng(2019, Apr). Angiotensin II Inhibits DDAH1-nNOS Signaling through AT1R and μOR Dimerization in the Central Nervous System to Modulate Central Control of Blood Pressure. The FASEB Journal, Vol. 33, No. 1 Supplement 872.4.
2. Gwo-Ching Sun, Yi-Chung Wu, Ching-Jiunn Tseng, Pei-Wen Cheng. Resveratrol Decrease of Reactive Oxygen Species-Derived Cognitive Impairment in Angiotensin II Induced Rat Model of Early Alzheimer’s disease. 18th World Congress of Basic and Clinical Pharmacology. Jul 2, 2018. 
3. Hsin-Hung Chen, Pei-Wen Cheng and Ching-Jiunn Tseng (2017, Apr). Fructose induced neurogenic hypertension is mediated by superoxide overexpression and stimulates p38 MAPK-induced central insulin resistance in the central nervous system. The FASEB Journal, vol. 31 no. 1 Supplement 883.3.
4. Ching-Jiunn Tseng and Pei-Wen Cheng (2015, Apr). Involvement of Two Distinct Signalling Pathways in IGF-1-Mediated Central Control of Hypotensive Effects in Normotensive and Hypertensive Rats. The FASEB Journal, vol. 29 no. 1 Supplement 624.2. (SCI, 7/86, BIOLOGY).
5. Pei-Wen Cheng, Ching-Jiunn Tseng (2014, Aug). Inhibition of Rac1-derived reactive oxygen species by AMPK decreases blood pressure in a fructose-induced rat model of hypertension. JOURNAL OF NEUROCHEMISTRY, 130(suppl 1), 46-46. (SCI, 56/252, NEUROSCIENCES).

專書

Tseng C.J., Cheng P.W., Tung C.S. Pharmacology of the Nucleus Tractus Solitarii. PRIMER ON THE AUTONOMIC NERVOUS SYSTEM. Third Edition CH029 (3) (ISBN: 978-0-12-386525-0). San Diego, USA: Elsevier Academic Press. Nov, 2011.