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孔美蘭 博士

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    資料來源:臨床醫學研究科       
    高雄榮民總醫院 教學研究部|醫學研究科

    孔美蘭 博士

    Mei-Lang Kung, Ph.D.

    現任高雄榮民總醫院教學研究部高級助理研究員,研究聚焦於草本奈米製劑、金奈米功能性蛋白傳遞、癌症免疫/光熱協同療法,以及肝癌衍生生長因子於 DNA 損傷與腫瘤生物學中的角色。

    Herbal Nanomedicine Gold Nanoparticles Cancer Therapy HDGF DNA Damage Tumor Biology

    綜覽

    姓名 孔美蘭
    Mei-Lang Kung
    現職 高雄榮民總醫院
    教學研究部高級助理研究員
    資料來源 醫學研究科
    聯絡資訊 聯絡人:唐維
    twei@vghks.gov.tw

    學歷與學術經歷

    學術經歷

    2019/12/16–迄今
    高雄榮民總醫院 教學研究部 高級助理研究員
    2017/08/01–2019/12/15
    中山大學 化學系 助理研究員
    2012/08/01–2017/07/31
    中山大學 化學系 博士後研究員
    2003/09–2006/08
    高雄榮總 教學研究部 研究助理
    2002/07–2003/08
    臺大醫院 微生物與免疫學研究所 研究助理

    學歷

    2006/09–2012/07
    博士 國立中山大學 生物科學研究所
    2000/09–2002/07
    碩士 高雄醫學大學 生物化學研究所
    1996/09–2000/07
    學士 中山醫學大學 營養學系

    Office Hour 與 Wet-Lab Meeting

    Wet-Lab Meeting 每週一 8:30–11:00
    Office Hour 週一至週四下午 3:00–5:00

    研究室研究主題

    草本奈米製劑與腫瘤抑制

    開發草本奈米製劑作為新型植物化學藥劑,探討其在腫瘤抑制生長與轉移的效用與機轉。

    Herbal Nanomedicine Tumor Suppression

    金奈米功能性蛋白傳遞

    開發金奈米攜帶功能性蛋白或抗體,作為癌症免疫/光熱協同療法之應用。

    Gold Nanoparticles Immunotherapy Photothermal Therapy

    HDGF 與 DNA 損傷

    探討肝癌衍生生長因子(HDGF)在 UV 誘導 DNA 損傷中所扮演的角色與機轉。

    HDGF DNA Damage Hepatocellular Carcinoma

    Honors & Awards

    2021
    台灣泌尿科醫學會 110 年度「最佳學術活動獎-最佳海報獎」
    2018
    107 年臺綜大「年輕學者創新選拔」佳作獎
    2015
    New Advance in Generation Medicine, Cancer and Stem Cell 2015 優秀論文獎
    2013
    國際奈米科技研討會 IEEE Nanotechnology Materials and Devices Conference 優秀論文獎

    期刊論文

    Mei-Lang Kung, Siao Muk Cheng, Yun-Han Wang, Kai-Pi Cheng, Yi-Tsen Hsiao, Bertrand Chin-Ming Tan, and Yun-Wen Chen*. Deficiency of RNA adenosine deaminase (ADAR2) ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in male diet-induced obese mice. Communications Biology. 2024 May 17; 7(1):594. (SCI; 2022 IF=5.9)
    Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, and Yun-Wen Chen*. ADAR2 deficiency ameliorates nonalcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1. Journal of Cachexia, Sarcopenia and Muscle. DOI: 10.1002/jcsm.13460. (SCI; 2022 IF=8.9)
    Tsung-Hui Hu, Jian-Ching Wu, Shih-Tsung Huang, Tian-Huei Chu, Ting-Wei Shih, Yi-Chen Chang, Shih-Ming Yang, Pei-Chi Li, Chou-Yuan Ko, Kuo-Liang Huang, Mei-Lang Kung* and Ming-Hong Tai*. HDGF Stimulates Liver Tumorigenesis by Enhancing Reactive Oxygen Species Generation in Mitochondria. Journal of Biological Chemistry. 2023 Oct 10;299(11):105335. (SCI; 2022 IF=4.8)
    Mei-Lang Kung, Shih-Tsung Huang, Kuo-Wang Tsai, Tian-Huei Chu, and Shuchen Hsieh*. Nanosized zingerone-triggered anti-angiogenesis contributes to tumor suppression in human hepatocellular carcinoma. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 658:130697, 2023. (SCI; 2022 IF=5.2)
    Tian-Huei Chu, Chou-Yuan Ko, Po-Han Tai, Yi-Chen Chang, Chao-Cheng Huang, Tung-Yang Wu, Hoi-Hung Chan, Ping-Hsuan Wu, Chien-Hui Weng, Yu-Wei Lin, Mei-Lang Kung, Cheng-Chieh Fang, Jian-Ching Wu, Zhi-Hong Wen, Yung-Kuo Lee, Tsung-Hui Hu,* Ming-Hong Tai.* Leukocyte cell-derived chemotaxin 2 regulates epithelial-mesenchymal transition and cancer stemness in hepatocellular carcinoma. Journal of Biological Chemistry 2022. (SCI; 2022 IF=4.8)
    Man-Gang Lee, Yung-Kuo Lee, Shih-Chung Huang, Chen-Lin Chang, Chou-Yuan Ko, Wen-Chin Lee, Tung-Yuan Chen, Shiow-Jyu Tzou, Cheng-Yi Huang, Ming-Hong Tai, Yu-Wei Lin, Mei-Lang Kung, Ming-Chao Tsai, Yung-Lung Chen, Yi-Chen Chang, Zhi-Hong Wen, Chao-Cheng Huang,* and Tian-Huei Chu.* DLK2 Acts as a Potential Prognostic Biomarker for Clear Cell Renal Cell Carcinoma Based on Bioinformatics Analysis. Genes 2022, 13(4), 629. (SCI; 2021 IF=3.5)
    Cheng-Mei Yang, Tian-Huei Chu, Kuo-Wang Tsai, Shuchen Hsieh, and Mei-Lang Kung*. Phytochemically Derived Zingerone Nanoparticles Inhibit Cell Proliferation, Invasion and Metastasis in Human Oral Squamous Cell Carcinoma. Biomedicines 2022, 10(2), 320. (SCI; 2021 IF=4.757)
    Hui-Hwa Tseng, You-Zuo Chen, Nan-Hua Chou, Yen-Chih Chen, Chao-Chuan Wu, Li-Feng Liu, Yi-Fang Yang, Chung-Yu Yeh, Mei-Lang Kung, Ya-Ting Tu, Kuo-Wang Tsai*. Metformin inhibits gastric cancer cell proliferation by regulation of a novel Loc100506691-CHAC1 axis. Molecular Therapy: Oncolytics. 2021. (SCI; 2021 IF=6.311)
    Huey-Shan Hung, Kai-Bo Chang, Chang Ming Tang, Tian Ren Ku, Mei-Lang Kung, Alex Yang-Hao Yu, Chiung-Chyi Shen, Yi-Chin Yang, Hsien-Hsu Hsieh, Shan-hui Hsu*. Anti-inflammatory Fibronectin-AgNP for Regulation of Biological Performance and Endothelial Differentiation Ability of Mesenchymal Stem Cells. Int J Mol Sci. 2021 Aug 26; 22(17):9262. (SCI; 2021 IF=5.6)
    Huey-Shan Hung, Mei-Lang Kung, Yi-Chun Ke, Fang-Chung Chen, Chiung-Chyi Shen, Chang Ming Tang, Yi-Chin Yang, Chun-An Yeh, Hsien-Hsu Hsieh, Shan-hui Hsu*. Nanogold-Carried Graphene Oxide: Anti-inflammation and Increased Differentiation Capacity of Mesenchymal Stem Cells. Nanomaterials. 2021. (SCI; 2021 IF=5.719)
    Hui-Chen Chen, Mei-Lang Kung, Wei-Xiang Huang, Ru-Huei Fu, Alex Yang-Hao Yu, Ya-Tsu Yang, Huey-Shan Hung*. Delivery of Stromal-Derived Factor-1α via Biocompatible Gold Nanoparticles Promotes Dendritic Cells Viability and Migration. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 628:127298, 2021. (SCI; 2021 IF=5.2)
    Ruey-Hwang Chou, Meng-Yin Yang, Yi-Ping Yang, Chun-An Yeh, Wei-Yi Lai, Tzu-Wei Lin, Yuan-Chi Teng, Shu-Chen Hsieh, Mei-Lang Kung, Hsien-Hsu Hsieh, Huey-Shan Hung. Evaluating the Biocompatibility and Biological Performance of FePt-decorated Nano-epoxy Nanoparticles in Mesenchymal Stem Cells. Journal of the Chinese Medical Association. 2021 Oct 8. doi: 10.1097/JCMA.0000000000000627. (SCI; 2022 IF=3.0)
    Chiung-Chyi Shen, Meng-Yin Yang, Kai-Bo Chang, Chia-Hsuan Tseng, Yi-Ping Yang, Yi-Chin Yang, Mei-Lang Kung, Wei-Yi Lai, Tzu-Wei Lin, Hsien-Hsu Hsieh, Huey-Shan Hung*. Fabrication of Hyaluronic Acid-Gold Nanoparticles with Chitosan to Modulate Neural Differentiation of Mesenchymal Stem Cells. Journal of the Chinese Medical Association. 2021. (SCI; 2022 IF=3.0)
    Yen-Ju Chiu, Ho-Hsiang Tu, Mei-Lang Kung, Hung-Ju Wu and Yun-Wen Chen*. Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis. Biomedicine & Pharmacotherapy. 41:111848, 2021. (SCI; 2022 IF=7.419)
    Kai-Bo Chang, Chiung-Chyi Shen, Shan-hui Hsu, Chang Ming Tang, Yi-Chin Yang, Sin-Ying Liu, Tian Ren Ku, Mei-Lang Kung, Hsien-Hsu Hsieh, and Huey-Shan Hung*. Functionalized collagen-silver nanocomposites for evaluation of the biocompatibility and vascular differentiation capacity of mesenchymal stem cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 624:126814, 2021. (SCI; 2022 IF=5.2)
    Jui-Ho Wang, Tzung-Ju Lu, Mei-Lang Kung, Yi-Fang Yang, Chung-Yu Yeh, Ya-Ting Tu, Wei-Shone Chen, Kuo-Wang Tsai*. The Long Noncoding RNA LOC441461 (STX17-AS1) Modulates Colorectal Cancer Cell Growth and Motility. Cancers. 12:3171, 2020. (SCI; 2022 IF=5.2)
    Chien-Hui Weng, Chieh-Shan Wu, Jian-Ching Wu, Mei-Lang Kung, Ming-Hsiu Wu*, Ming-Hong Tai*. Cisplatin-Induced Giant Cells Formation Is Involved in Chemoresistance of Melanoma Cells. International Journal of Molecular Sciences. 21(21):7892, 2021. (SCI; 2022 IF=5.6)
    E-Ming Wang, Tsung-Hui Hu, Chao-Cheng Huang, Yi-Chen Chang, Shih-Ming Yang, Shih-Tsung Huang, Jian-Ching Wu, Yi-Ling Ma, Hoi-Hung Chan, Li-Feng Liu, Wen-Bin Lu, Mei-Lang Kung, Zhi-Hong Wen, Jui-Chu Wang, Chou-Yuan Ko, Wei-Lun Tsai, Tian-Huei Chu*, Ming-Hong Tai*. Hepatoma-derived Growth Factor Participates in Concanavalin A-induced Hepatitis. The FASEB Journal. 2020 Sep 28. doi: 10.1096/fj.202000511RR. (SCI; 2022 IF=4.8)
    Huey-Shan Hung*, Yang-Hao Yu, Shuchen Hsieh, Mei-Lang Kung, Hsiu-Yuan Huang, Ru-Huei Fu, Chun-An Yeh, Shan-Hui Hsu*. Enhanced biocompatibility and differentiation capacity of mesenchymal stem cells on polydimethylsiloxane by topographical patterned dopamine. ACS Applied Materials & Interfaces. 12(40):44393-44406, 2020. (SCI; 2022 IF=9.5)
    Bi-Wen Yeh, Liang-En Yu, Ching-Chia Li, Juan-Cheng Yang, Wei-Ming Li, Yang-Chang Wu, Yu-Ching Wei, Hsueh-Te Lee, Mei-Lang Kung*, Wen-Jeng Wu*. The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy. Toxicology and Applied Pharmacology, 402:115129, 2021. (SCI; 2022 IF=3.8)
    Huey-Shan Hung, Da-Tian Bau, Chun-An Yeh, Mei-Lang Kung*. Evaluation of cellular uptake mechanisms for AuNP-collagen-Avemar nanocarrier on transformed and non-transformed cell lines. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 580(5):123791, 2019. (SCI; 2022 IF=5.2)
    Shuchen Hsieh*, I-Tin Li, Chiung-Wen Hsieh, Mei-Lang Kung, Shu-Ling Hsieh, Deng-Chyang Wu, Chao-Hung Kuo, Ming-Hong Tai, Huay-Min Wang, Wen-Jeng Wu, and Bi-Wen Yeh. Advances in Cellular Nanoscale Force Detection and Manipulation. Arabian Journal of Chemistry, 12:3163-3171, 2019. (SCI; 2022 IF=6.0)
    Tian-Huei Chu, Shih-Tsung Huang, Sheau-Fang Yang, Chia-Jung Li, Hong-Wei Lin, Bi-Chuang Weng, Shih-Ming Yang, Shih-Chung Huang, Jien-Ching Wu, Yi-Chen Chang, Zhi-Hong Wen, Yi-Ming Chen, Wen-Jeng Wu, Mei-Lang Kung, Po-Han Tai, Deng-Chyang Wu and Ming-Hong Tai. Hepatoma-derived Growth Factor Participates in Helicobacter Pylori-induced Neutrophils Recruitment, Gastritis and Gastric Carcinogenesis. Oncogene, 38(37):6461-6477, 2019. (SCI; 2022 IF=8.756)
    Mei-Lang Kung, P.Y. Lin, S.T. Huang, M.H. Tai, S.L. Hsieh, C.C. Wu, B.W. Yeh, W.J. Wu, S. Hsieh. Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines. ACS Applied Materials & Interfaces 11(1):137-150, 2019. (SCI; 2021 IF=9.5)
    C.C. Huang, S.H. Cheng, C.H. Wu, W.Y. Li, J.S. Wang, Mei-Lang Kung, T.H. Chu, S.T. Huang, C.T. Feng, S.C. Huang, M.H. Tai. Delta-like 1 homologue promotes tumorigenesis and epithelial-mesenchymal transition of ovarian high-grade serous carcinoma through activation of Notch signaling. Oncogene 38(17):3201-3215, 2019. (SCI; 2021 IF=8.756)

    研討會論文

    2024-03-23 113 年第 38 屆生物醫學聯合學術年會(JACBS); HDGF induces ROS generation and modulates mitochondria activities to promote liver carcinogenesis. Yu-Wei Lin(林裕為), Tsung-Hui Hu(胡琮輝), Jian-Ching Wu(吳健慶), Ming-Hong Tai(戴明泓), Mei-Lang Kung(孔美蘭)*
    2023-07-21 112 年臺灣奈米生醫年會; Herbal-Derived Zingerone Nanoparticles Interfere with Cell Anchorage-Associated Signaling and Suppress Cell Motility in Melanoma B16F10 Cells. Jun-Yih Chen(陳俊逸), Li-Wen Chu(朱立雯), Yun-Wen Chen(陳韻雯), Shuchen Hsieh(謝淑貞) and Mei-Lang Kung(孔美蘭)*
    2021-12-26 110 年台灣泌尿科醫學會; Small Non-coding MicroRNAs (miRNAs) Target Hepatoma-Derived Growth Factor (HDGF) as a Novel Therapeutic Strategy for Urothelial Carcinoma. 孔美蘭, 葉碧雯, 吳文正*
    聯絡資訊 聯絡人:唐維|資料來源:醫學研究科|聯絡資訊:twei@vghks.gov.tw
    twei@vghks.gov.tw
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