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孔美蘭 博士

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    資料來源:臨床醫學研究科       

    學術經歷:

    高雄榮民總醫院教學研究部 高級助理研究員 (2019/12/16~迄今) 
    中山大學化學系 助理研究員 (2017/08/01至2019/12/15)
    中山大學化學系 博士後研究員 (2012/08/01至2017/07/31)
    高雄榮總教學研究部 研究助理 (2003/09至2006/08)
    臺大醫院微生物與免疫學研究所 研究助理 (2002/07至2003/08)

    學歷

    1. 博士 國立中山大學 生物科學研究所(2006/09至2012/07) 
    2. 碩士 高雄醫學大學 生物化學研究所(2000/9至2002/07) 
    3. 學士 中山醫學大學 營養學系(1996/09至2000/07)

    Art editor Img

    實驗室成員

    • 研究助理4員:尤碩瑜、 葉忠祐、 黃稚婷、葉鏸瑩
    • 碩士在職專班研究生:黃昱嫻、蔡郁青
    1. 開發草本奈米製劑作為新型植物化學藥劑在腫瘤抑制生長與轉移的效用與機轉
    2. 開發金奈米攜帶功能性蛋白(抗體)做為癌症的免疫/光熱協同療法之應用
    3. 探討肝癌衍生生長因子(HDGF)在UV誘導DNA損傷扮演的角色與機轉

    2018 107年臺綜大「年輕學者創新選拔」佳作獎

    2015 New Advance in Generation Medicine, Cancer and Stem Cell 2015, 優秀論文獎

    2013國際奈米科技研討會(IEEE Nanotechnology Materials and Devices Conference), 優秀論文獎

    1. Huey-Shan Hung, Da-Tian Bau, Chun-An Yeh, Mei-Lang Kung*, Evaluation of cellular uptake mechanisms for AuNP-collagen-Avemar nanocarrier on transformed and non-transformed cell lines, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 580 (5):123791 (2019).(SCI; IF=3.131)
    2. Shuchen Hsieh*, I-Tin Li, Chiung-Wen Hsieh, Mei-Lang Kung, Shu-Ling Hsieh, Deng-Chyang Wu, Chao-Hung Kuo, Ming-Hong Tai, Huay-Min Wang, Wen-Jeng Wu, and Bi-Wen Yeh, Advances in Cellular Nanoscale Force Detection and Manipulation, Arabian Journal of Chemistry,12: 3163- 3171(2019). (SCI; IF=3.298)
    3. Tian-Huei Chu, Shih-Tsung Huang, Sheau-Fang Yang, Chia-Jung Li, Hong-Wei Lin, Bi-Chuang Weng, Shih-Ming Yang, Shih-Chung Huang, Jien-Ching Wu, Yi-Chen Chang, Zhi-Hong Wen, Yi-Ming Chen, Wen-Jeng Wu, Mei-Lang Kung, Po-Han Tai, and Deng-Chyang Wu and Ming-Hong Tai,Hepatoma-derived Growth Factor Participates in Helicobacter Pylori-induced Neutrophils Recruitment, Gastritis and Gastric Carcinogenesis, Oncogene, 38(37):6461-6477 (2019).(SCI; IF=6.854)
    4. Mei-Lang Kung, P.Y. Lin, S.T. Huang, M.H. Tai, S.L. Hsieh, C.C. Wu, B.W. Yeh, W.J. Wu, S. Hsieh, Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines, ACS applied materials & interfaces 11(1): 137-150(2019).(SCI; IF=8.456)
    5. C.C. Huang, S.H. Cheng, C.H. Wu, W.Y. Li, J.S. Wang, Mei-Lang Kung, T.H. Chu, S.T. Huang, C.T. Feng, S.C. Huang, M.H. Tai, Delta-like 1 homologue promotes tumorigenesis and epithelial-mesenchymal transition of ovarian high-grade serous carcinoma through activation of Notch signaling, Oncogene 38(17) (2019) 3201-3215.(SCI; IF=6.854)
    6. C.C. Huang, H.M. Kuo, P.C. Wu, S.H. Cheng, T.T. Chang, Y.C. Chang, Mei-Lang Kung, D.C. Wu, J.H. Chuang, M.H. Tai, Correction to: Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells, Angiogenesis 21(2):299-312 (2018).(SCI; IF=5.759)
    7. Yun-Wen Chen, Shu-Chen Hsieh, Yi-Chin Yang, Shan-hui Hsu, Mei-Lang Kung, Pei-Ying Lin, Hsien-Hsu Hsieh, Ching-Hao Lin, Cheng-Ming Tang, Huey-Shan Hung*, Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration, Nanomedicine: Nanotechnology, Biology and Medicine. 14(3):699-711 (2018). (SCI; IF=5.57)
    8. Huang-Yu Chang, Shu-Ling Chen, Meng-Ru Shen, Mei-Lang Kung, Lee-Ming Chuang and Yun-Wen Chen*, Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells, Scientific Reports, 7(1):3515 (2017). (SCI; IF=4.525)
    9. Mei-Lang Kung, Ming-Hong Tai, Pei-Ying Lin, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh, Huey-Shan Hung, Chao-Hung Kuo, Yun-Wen Chen, Shu-Ling Hsieh and Shuchen Hsieh*, Silver decorated copper oxide (Ag@CuO) nanocomposite enhances ROS-mediated bacterial architecture collapse, Colloids and Surfaces B: Biointerfaces, Vol 155, P 399-407 (2017) (SCI; IF=3.973)
    10. Shu-Chen Hsieh, Hui-Jye Chen, Shan-hui Hsu, Yi-Chin Yang, Cheng-Ming Tang, Mei-Yun Chu, Pei-Ying Lin, Ru-Huei Fu, Mei-Lang Kung, Yun-Wen Chen, Bi-Wen Yeh, and Huey-Shan Hung*, Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen-Gold Nanocomposites, ACS Applied Materials & Interfaces, Vol 8(42), p 28982–29000 (2016) (SCI; IF=8.456)
    11. Yun-Wen Chen, Chiung-Wen Chang, Huey-Shan Hung, Mei-Lang Kung, Bi-Wen Yeh and Shuchen Hsieh*,Magnetite nanoparticle interactions with insulin amyloid fibrils,Nanotechnology, Vol 27(41), p 415702 (2016) (SCI; IF=3.399)
    12. Mei-Lang Kung, Pei-Ying Lin, Shi-Wei Peng, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh, Ming-Hong Tai, Huey-Shan Hung, Shuchen Hsieh*,Biomimetic polymer-based Ag nanocomposites as a antimicrobial platform, Applied Materials Today, Vol 4, p 31–39 (2016).(SCI; IF=8.013)
    13. Mei-Lang Kung, Chiung-Wen Hsieh, Ming-Hong Tai, Chien-Hui Weng, Deng-Chyang Wu, Wen-Jeng Wug, , Bi-Wen Yeh, Shu-Ling Hsieh, Chao-Hung Kuo, Huey-Shan Hung,p andShuchen Hsieh*,Nanoscale Characterization Illustrates the Cisplatin-Mediated the Biomechanical Changes of B16-F10 Melanoma Cells,Physical Chemistry Chemical Physics, 2;18(10):7124-31 (2016). (SCI; IF=3.567)
    14. Chen SC, Hu TH, Huang CC, Mei-Lang Kung, Chu TH, Yi LN, Huang ST, Chan HH, Chuang JH, Liu LF, Wu HC, Wu DC, Chang MC*, Tai MH*. Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis.Oncotarget. 30;6(18):16253-70 (2015).
    15. Mei-Lang Kung, S. L. Hsieh, C. C. Wu, T. H. Chu, Y. C. Lin,B. W. Yeh and S. Hsieh*, Enhanced Reactive Oxygen Species Overexpression by CuO Nanoparticles in Poorly Differentiated Hepatocellular Carcinoma Cells, Nanoscale, Vol 7(5), p 1820-1829 (2015). (SCI; IF=6.97).
    16. Mei-Lang Kung, Pei-Ying Lin, Chiung-Wen Hsieh and Shuchen Hsieh*, Aqueous self-assembly and surface-functionalized nanodots for live cell imaging and labeling. Nano Research, 7(8): 1164-1176 (2014). (SCI; IF= 8.515)
    17. Mei-Lang Kung,Pei-Ying Lin,Chiung-Wen Hsieh,Ming-Hong Tai,Deng-Chyang Wu, Chao-Hung Kuo,Shu-Ling Hsieh,Hui-Ting Chenand Shuchen Hsieh*. Bifunctional Peppermint Oil Nanoparticles for Antibacterial Activityand Fluorescence Imaging.ACS Sustainable Chemistry & Engineering, 2:1769-1775. (2014). (SCI; IF= 6.97)
    18. Pei-Ying Lin, Chiung-Wen Hsieh, Mei-Lang Kung, Ling-YaChu, Huei-Jhen Huang, Hui-Ting Chen, Deng-Chyang Wu, Chao-Hung Kuo, Shu-Ling Hsieh, Shuchen Hsieh*.Eco-friendly synthesis of shrimp egg-derived carbon dots for fluorescent bioimaging.J Biotechnol. 10(189):114-9, (2014). (SCI; IF=3.163)
    19. Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok Hung Lai, Zhi-Hong Wen, Ping-I Hsu andMing-Hong Tai*. Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN.Oncotarget,5(6):1475-90, (2014).
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