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孔美蘭 博士

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    資料來源：臨床醫學研究科       

    學術經歷：

    高雄榮民總醫院教學研究部 高級助理研究員 (2019/12/16~迄今) 
    中山大學化學系 助理研究員 (2017/08/01至2019/12/15)
    中山大學化學系 博士後研究員 (2012/08/01至2017/07/31)
    高雄榮總教學研究部 研究助理 (2003/09至2006/08)
    臺大醫院微生物與免疫學研究所 研究助理 (2002/07至2003/08)

    學歷

    1. 博士 國立中山大學 生物科學研究所(2006/09至2012/07) 
    2. 碩士 高雄醫學大學 生物化學研究所(2000/9至2002/07) 
    3. 學士 中山醫學大學 營養學系(1996/09至2000/07)

    Art editor Img

    實驗室成員

    • 研究助理4員：尤碩瑜、 葉忠祐、 黃稚婷、葉鏸瑩
    • 碩士在職專班研究生：黃昱嫻、蔡郁青
    1. 開發草本奈米製劑作為新型植物化學藥劑在腫瘤抑制生長與轉移的效用與機轉
    2. 開發金奈米攜帶功能性蛋白(抗體)做為癌症的免疫/光熱協同療法之應用
    3. 探討肝癌衍生生長因子(HDGF)在UV誘導DNA損傷扮演的角色與機轉

    2018 107年臺綜大「年輕學者創新選拔」佳作獎

    2015 New Advance in Generation Medicine, Cancer and Stem Cell 2015, 優秀論文獎

    2013國際奈米科技研討會(IEEE Nanotechnology Materials and Devices Conference), 優秀論文獎

    1. Huey-Shan Hung*, Yang-Hao Yu, Shuchen Hsieh, Mei-Lang Kung, Hsiu-Yuan Huang, Ru-Huei Fu, Chun-An Yeh, Shan-Hui Hsu*, Enhanced biocompatibility and differentiation capacity of mesenchymal stem cells on polydimethylsiloxane by topographical patterned dopamine. ACS applied materials & interfaces. 2020 Jul 22. doi: 10.1021/acsami.0c05747. Online ahead of print. (SCI; IF=8.758)
    2. Bi-Wen Yeh, Liang-En Yu, Ching-Chia Li, Juan-Cheng Yang, Wei-Ming Li, Yang-Chang Wu, Yu-Ching Wei, Hsueh-Te Lee, Mei-Lang Kung*, Wen-Jeng Wu*, The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy. Toxicology and Applied Pharmacology, 2020 Jul 13:115129. doi: 10.1016/j.taap.2020.115129. Online ahead of print. (SCI; IF=3.347)
    3. Huey-Shan Hung, Da-Tian Bau, Chun-An Yeh, Mei-Lang Kung*, Evaluation of cellular uptake mechanisms for AuNP-collagen-Avemar nanocarrier on transformed and non-transformed cell lines, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 580 (5):123791 (2019). (SCI; IF=3.131)
    4. Shuchen Hsieh*, I-Tin Li, Chiung-Wen Hsieh, Mei-Lang Kung, Shu-Ling Hsieh, Deng-Chyang Wu, Chao-Hung Kuo, Ming-Hong Tai, Huay-Min Wang, Wen-Jeng Wu, and Bi-Wen Yeh, Advances in Cellular Nanoscale Force Detection and Manipulation, Arabian Journal of Chemistry, 12: 3163- 3171 (2019). (SCI; IF=3.298)
    5. Tian-Huei Chu, Shih-Tsung Huang, Sheau-Fang Yang, Chia-Jung Li, Hong-Wei Lin, Bi-Chuang Weng, Shih-Ming Yang, Shih-Chung Huang, Jien-Ching Wu, Yi-Chen Chang, Zhi-Hong Wen, Yi-Ming Chen, Wen-Jeng Wu, Mei-Lang Kung, Po-Han Tai, and Deng-Chyang Wu and Ming-Hong Tai, Hepatoma-derived Growth Factor Participates in Helicobacter Pylori-induced Neutrophils Recruitment, Gastritis and Gastric Carcinogenesis, Oncogene, 38(37): 6461-6477 (2019). (SCI; IF=6.854)
    6. Mei-Lang Kung, P.Y. Lin, S.T. Huang, M.H. Tai, S.L. Hsieh, C.C. Wu, B.W. Yeh, W.J. Wu, S. Hsieh, Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines, ACS applied materials & interfaces 11(1): 137-150 (2019). (SCI; IF=8.758)
    7. C.C. Huang, S.H. Cheng, C.H. Wu, W.Y. Li, J.S. Wang, Mei-Lang Kung, T.H. Chu, S.T. Huang, C.T. Feng, S.C. Huang, M.H. Tai, Delta-like 1 homologue promotes tumorigenesis and epithelial-mesenchymal transition of ovarian high-grade serous carcinoma through activation of Notch signaling, Oncogene 38(17) (2019) 3201-3215. (SCI; IF=6.854)
    8. C.C. Huang, H.M. Kuo, P.C. Wu, S.H. Cheng, T.T. Chang, Y.C. Chang, Mei-Lang Kung, D.C. Wu, J.H. Chuang, M.H. Tai, Correction to: Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells, Angiogenesis 21(2):299-312 (2018). (SCI; IF=5.759)
    9. Yun-Wen Chen, Shu-Chen Hsieh, Yi-Chin Yang, Shan-hui Hsu, Mei-Lang Kung, Pei-Ying Lin, Hsien-Hsu Hsieh, Ching-Hao Lin, Cheng-Ming Tang, Huey-Shan Hung*, Functional engineered mesenchymal stem cells with fibronectin-gold composite coated catheters for vascular tissue regeneration, Nanomedicine: Nanotechnology, Biology and Medicine. 14(3):699-711 (2018). (SCI; IF=5.57)
    10. Huang-Yu Chang, Shu-Ling Chen, Meng-Ru Shen, Mei-Lang Kung, Lee-Ming Chuang and Yun-Wen Chen*, Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells, Scientific Reports, 7(1):3515 (2017). (SCI; IF=4.525)
    11. Mei-Lang Kung, Ming-Hong Tai, Pei-Ying Lin, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh, Huey-Shan Hung, Chao-Hung Kuo, Yun-Wen Chen, Shu-Ling Hsieh and Shuchen Hsieh*, Silver decorated copper oxide (Ag@CuO) nanocomposite enhances ROS-mediated bacterial architecture collapse, Colloids and Surfaces B: Biointerfaces, Vol 155, P 399-407 (2017) (SCI; IF=3.973)
    12. Shu-Chen Hsieh, Hui-Jye Chen, Shan-hui Hsu, Yi-Chin Yang, Cheng-Ming Tang, Mei-Yun Chu, Pei-Ying Lin, Ru-Huei Fu, Mei-Lang Kung, Yun-Wen Chen, Bi-Wen Yeh, and Huey-Shan Hung*, Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen-Gold Nanocomposites, ACS Applied Materials & Interfaces, Vol 8(42), p 28982–29000 (2016) (SCI; IF=8.456)
    13. Yun-Wen Chen, Chiung-Wen Chang, Huey-Shan Hung, Mei-Lang Kung, Bi-Wen Yeh and Shuchen Hsieh*, Magnetite nanoparticle interactions with insulin amyloid fibrils, Nanotechnology, Vol 27(41), p 415702 (2016) (SCI; IF=3.399)
    14. Mei-Lang Kung, Pei-Ying Lin, Shi-Wei Peng, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh, Ming-Hong Tai, Huey-Shan Hung, Shuchen Hsieh*, Biomimetic polymer-based Ag nanocomposites as a antimicrobial platform, Applied Materials Today, Vol 4, p 31–39 (2016). (SCI; IF=8.352)
    15. Mei-Lang Kung, Chiung-Wen Hsieh, Ming-Hong Tai, Chien-Hui Weng, Deng-Chyang Wu, Wen-Jeng Wug, , Bi-Wen Yeh, Shu-Ling Hsieh, Chao-Hung Kuo, Huey-Shan Hung,p and Shuchen Hsieh*, Nanoscale Characterization Illustrates the Cisplatin-Mediated the Biomechanical Changes of B16-F10 Melanoma Cells, Physical Chemistry Chemical Physics, 2;18(10):7124-31 (2016). (SCI; IF=3.567)
    16. Chen SC, Hu TH, Huang CC, Mei-Lang Kung, Chu TH, Yi LN, Huang ST, Chan HH, Chuang JH, Liu LF, Wu HC, Wu DC, Chang MC*, Tai MH*. Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis. Oncotarget. 30;6(18):16253-70 (2015).
    17. Mei-Lang Kung, S. L. Hsieh, C. C. Wu, T. H. Chu, Y. C. Lin, B. W. Yeh and S. Hsieh*, Enhanced Reactive Oxygen Species Overexpression by CuO Nanoparticles in Poorly Differentiated Hepatocellular Carcinoma Cells, Nanoscale, Vol 7(5), p 1820-1829 (2015). (SCI; IF=6.97).
    18. Mei-Lang Kung, Pei-Ying Lin, Chiung-Wen Hsieh and Shuchen Hsieh*, Aqueous self-assembly and surface-functionalized nanodots for live cell imaging and labeling. Nano Research, 7(8): 1164-1176 (2014). (SCI; IF= 8.515)
    19. Mei-Lang Kung, Pei-Ying Lin, Chiung-Wen Hsieh, Ming-Hong Tai, Deng-Chyang Wu, Chao-Hung Kuo, Shu-Ling Hsieh, Hui-Ting Chen and Shuchen Hsieh*. Bifunctional Peppermint Oil Nanoparticles for Antibacterial Activity and Fluorescence Imaging. ACS Sustainable Chemistry & Engineering, 2:1769-1775. (2014). (SCI; IF= 6.97)
    20. Pei-Ying Lin, Chiung-Wen Hsieh, Mei-Lang Kung, Ling-Ya Chu, Huei-Jhen Huang, Hui-Ting Chen, Deng-Chyang Wu, Chao-Hung Kuo, Shu-Ling Hsieh, Shuchen Hsieh*. Eco-friendly synthesis of shrimp egg-derived carbon dots for fluorescent bioimaging. J Biotechnol. 10(189):114-9, (2014). (SCI; IF=3.163)
    21. Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok Hung Lai, Zhi-Hong Wen, Ping-I Hsu and Ming-Hong Tai*. Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. Oncotarget, 5(6):1475-90, (2014).
    22. Pei-Ying Lin, Chiung-Wen Hsieh, Mei-Lang Kung, Shuchen Hsieh*. “Substrate-Free Self-Assembled SiOx-Core Nanodots from Alkylalkoxysilane as a Multicolor Photoluminescence Source for Intravital Imaging”. Scientific Reports, 3:1703, (2013). (SCI; IF= 4.525)
    23. Han-En Tsai,Jian-Ching Wu, Mei-Lang Kung, Li-Feng Liu, Lai-Hsin Kuo,Hsiao-Mei Kuo, San-Cher Chen, Elsa C. Chan, Chieh-Shan Wu, Ming-Hong Tai*, Guei-Sheung Liu*. “Up-Regulation of Hepatoma-Derived Growth Factor Facilities Tumor Progression in Malignant Melanoma”. PLOS ONE, 8(3):e59345, (2013) (SCI; IF= 4.411)
    24. Han-En Tsai, Guei-Sheung Liu, Mei-Lang Kung, Li-Feng Liu, Jian-Ching Wu,Chia-Hua Tang, Ching-Hui Huang, San-Cher Chen, Hing-Chung Lam,Chieh-Shan Wu, Ming-Hong Tai*. “Downregulation of Hepatoma-derived Growth Factor Contributes to Retarded Lung Metastasis viainhibition of Epithelial-Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma”. Molecular Cancer Therapeutics, 12(6):1016-1025, (2013). (SCI; IF= 4.856)
    25. Mei-Lang Kung, Han-En Tsai, Tsung-Hui Hud, Hsiao-Mei Kuo, Li-Fen Liu , San-Cher Chen, Pey-Ru Lin, Yi-Ling Maa, E-Ming Wang, Guei-Sheung Liu, Jong-Kang Liu*, Ming-Hong Tai*. “Hepatoma-derived growth factor stimulates podosome rosettes formation 3 in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt 4 pathway”. Biochemical and Biophysical Research Communications. 425(2):169-176, (2012). (SCI; IF= 2.705)
    26. Han-En Tsai, Li-Feng Liu, Gregory J. Dusting, Wen-Tsan Weng, San-Cher Chen, Mei-Lang Kung, Richard Tee, Guei-Sheung Liu*, Ming-Hong Tai*. “Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway”. Journal of Gene Medicine, 14(1):44-53,(2012). (SCI; IF= 1.561)
    27. San-Cher Chen, Mei-Lang Kung, Tsung-Hui Hu, Hsuan-Yu Chen, Jien-Ching Wu, Hsiao-Mei Kuo, Han-En Tsai, Yu-Wei Lin, Zi-Hong Wen, Jong-Kang Liu, Ming-Hsin Yeh, Ming-Hong Tai*. “Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial– mesenchymal transition”. Journal of Pathology, 228(2):158-169,(2012). (SCI; IF=5.942)
    28. Shu-Shong Hsu, Chih-Hao Chen, Guei-Sheung Liu, Ming-Hong Tai, Jyh-Seng Wang, Jain-Ching Wu, Mei-Lang Kung, Elsa C. Chan, Li-Feng Liu*. “Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas”. Journal of Neurooncology, 107(1):101-109, (2012). (SCI; IF=3.129)
    29. Jiin-Haur Chuang, Hui-Ching Chuang, Chao-Cheng Huang, Chia-Ling Wu, Yung-Ying Du, Mei-Lang Kung, Chih-Hao Chen, San-Cher Chen, Ming-Hong Tai*. “Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells”. Journal of Biomedical Science, 18:65-77, (2012). (SCI; IF=5.203)
    30. Kee-Lung Chang, Mei-Lang Kung, Nan-Haw Chow, Shu-Jem Su*.”Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1”.Biochem Pharmacol, 67(4):717-26, (2004). (SCI; IF=4.235)
    31. Shu-Jem Su, Nan-Haw Chow, Mei-Lang Kung, Thu-Ching Hung and Kee-Lung Chang. “Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity”.Nutr Cancer, 45(1):113-123, (2003). (SCI; IF=2.261)
    1. 2018-03-23 高醫胃腸科春季研討會: Microenvironmental biophysical niches remodulate cellular behaviors. 許文鴻, 孔美蘭, 胡晃鳴, 謝淑貞, 吳登強, 郭昭宏
    2. Dec 06, 2015癌症及幹細胞研討會 (New Advance in Generation Medicine, Cancer and Stem Cell): I: Cisplatin-Mediated Cytoskeletal Rearrangement and Biomechanical Changes of Melanoma Cell as Probing by Atomic Force Microscopy. Mei-Lang Kung, Chiung-Wen Hsieh, Chien-Hui Wen, Ming-Hong Tai, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh and Shuchen Hsieh*
    3. 2015生醫工程應用研討會(Symposium on Engineering Medicine and Biology Applications (SEMBA): I: Specific Biomolecules Conjugated with Nanodots for Cancer Bioimaging and Biolabeling. Mei-Lang  Kung, Lin PY and Hsieh S* II: Essential Oil-Derived Nanoparticles from Peppermint Oil for Antibacterial and Fluorescence Imaging. Mei-Lang Kung, Lin PY, Chao-Hung Kuo, Deng-Chyang Wu, Chung-Jung Liu and Hsieh S*
    4. 2014高雄醫學大學傳染病與癌症國際學術研討會(2014 ICIDC), Bioimaging and Biolabeling for Cancer Cell Detection Using Specific Biomolecules Conjugated with Nanodots. Mei-Lang Kung, Lin PY and Hsieh S*
    5. 2014高雄醫學大學消化系聯合學術演講年會, 2014, 3, 8-9.原子力顯微鏡探測肝癌細胞之表面黏著力 (Investigation the surface adhesion of Hepatocellular Carcinoma HepG2 and SK-Hep-1 cells using Atomic Force Microscopy), 鄭智尹 孔美蘭 鄭光宏 陳俊霖 謝淑貞 吳登強,
    6. IEEE Nanotechnology Materials and Devices Conference, Comparison the Effects of Nanosized Copper Oxide between the Well and Poor Differentiation Hepatoma Cell Lines. 2013 Nanotechnology Materials and Device Conference, 國立成功大學, 2013. 10. 6-9.  Mei-Lang Kung, Lin PY, Tai MH, Cheng KH, Hsieh SL, Tu LW, Wang HYJ, Kuo CH, Wu DC, Hsieh S
    7. The Inaugural Xiamen Winter Symposium-Molecular Mechanisms and Signalling in Cancer Biology(廈門冬季學術會議), Xiamen University, Xiamen, China February 21 -23, 2011 “Hepatoma-Derived Growth Factor stimulated the cell migration via activation of PI3K/Akt / RHO GTPases pathway” Mei-Lang Kung, Jong-Kang Liu, Ming-Hong Tai. Poster Submission
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