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李佳榮 博士

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    資料來源：臨床醫學研究科       

    學經歷

    1. 高榮婦女醫學部 副研究員 (2019.02-) 
    2. 教育部頒定助理教授(助字第149431號) (2020.03-)
    3. 秀傳紀念醫院醫研部 研究員兼組長 (2017.02-2019.02)  
    4. 秀傳醫學雜誌執行編輯 (2017.07-2019.01)
    5. 國立成功大學臨床醫學研究所 博士後研究員 (2015.08-2017.02)
    6. 慈濟大學 醫學科學研究所 博士 (2008.09-2015.07)
    7. 中央研究 細胞與個體生物學研究所 (2006.06-2007.12)

    Art editor Img

    Mitochondria are essential organelles and are present in all of our cells. They are known as the “powerhouse” of the cell since they burn carbon to make chemical energy (ATP). They are also the “poison-cupboard” of our cells since if the mitochondrial outer membrane is opened, proteins are released that cause cell death. Cell death is important since as our cells divide we must kill others-otherwise cancers may arise and so this process is very well regulated. Our goal is to discover principles of mitochondrial signal transduction and to study their role in the maintenance of human health, in aging, and in the development of disease. To understand organizing principles of mitochondrial communication and signal transduction, we integrate knowledge from mitochondrial biology, reproduction, aging biology, cancer biology, and mitochondrial medicine. Our experimental systems include complimentary human, cellular, and animal models.

    -客座主編:

    • Journal of Oncology (IF: 4.593; 2018)

    Special Issue: Diagnostic, Prognostic and Predictive Biomarkers in Breast Cancer

    https://www.hindawi.com/journals/jo/si/284278/cfp/

    • Biomolecules (IF: 4.694; 2019)

    Special Issue: Oxidative Stress and Mitochondrial Dysfunction in Human Diseases: Pathophysiology, Predictive Biomarkers, Therapeutic

    https://www.mdpi.com/journal/biomolecules/special_issues/oxidative_stress_mitochondrial_dysfunction

    -期刊審查委員:

    Cancers (IF: 6.162)

    Journal of Clinical Medicine (IF: 5.688)

    Cells (IF: 5.656)

    Journal of Experimental & Clinical Cancer Research (IF: 5.646)

    Journal of Advanced Research (IF: 5.045)

    Biomolecules (IF: 4.694)

    Journal of Oncology (IF: 4.593)

    Cancer Biology & Medicine (IF: 4.467)

    International Journal of Molecular Sciences (IF: 4.183)

    Nutrients (IF: 4.171)

    Neurotoxicity Research (IF: 3.538)

    OncoTargets and Therapy (IF: 2.311)

    Evidence-Based Complementary and Alternative Medicine (IF: 2.064)

    Medical Science Monitor (IF: 1.433)

     

    • 2020/08 受邀至菲律賓國際亞太生殖醫學研討會(ASPIRE)大會講者
    • 2019/11 獲選乳癌防治基金會(TBCF)優秀論文獎
    • 2019/09論文獲選為該期封面故事 Theranostics (IF: 8.063). Vol:9, Issue:22.
    • 2019/08 獲選生殖醫學年會(TSRM)口頭論文競賽第一名
    • 2019/07 受邀至台灣醫事檢驗年會大會講者
    • 2019/04論文獲選為該期封面故事 J Clin Med. (IF: 5.688). Vol:8, Issue:4.
    • 2019/01 受邀至台南市立醫院全院性演講
    • 2018/10 獲選粒線體醫學年會(TSMRM)傑出論文獎
    • 2018/08論文獲選為該期封面故事 J Clin Med. (IF: 5.688). Vol:7, Issue:8.
    • 2018/06 受邀至台中慈濟醫院醫研部演講
    • 2017/11 受邀為粒線體醫學年會(TSMRM)大會講者
    • 2017/08 受邀至台南市立醫院全院性演講
    • 2016/11 獲科技部補助專家學者出席國際會議
    • 2016/10 獲細胞分子生物學會補助專家學者出席國際會議
    • 2015/09 受邀為中國南京國際生醫工程與製藥科學年會(ICBEPS)國際會議大會講者
    • 2014/11 獲選亞洲粒線體醫學年會(ASMRM)傑出論文獎
    • 2014/11 獲選慈濟學術會議傑出論文獎
    • 2012/10 獲選粒線體醫學年會(TSMRM)傑出論文獎
    • 2012/10 獲細胞分子生物學會補助專家學者出席國際會議
    • 2011/07 獲波士頓腫瘤休眠研討補助專家學者出席國際會議

     

    1. Wu MY, Lai TT, Liao WT, Li CJ*. Clinicopathological and prognostic significance and molecular mechanism in uveal melanoma. Ther Adv Med Oncol. In press. IF – 5.67. 2020.
    2. Tsai HW, Wang PH, Hsu PT, Chen SN, Lin LT, Li CJ, Tsui KH. Laser irradiation pretreatment improves endometrial preparation of frozen-thawed embryo transfer in recurrent implantation failure patients. Gynecol Endocrinol. 13:1. IF – 1.406. 2020.
    3. Li CJ, Chen HM, Lai JC. Diagnostic, prognostic, and predictive biomarkers in breast cancer. J Oncol. 2020:1835691. IF – 2.6. 2020.
    4. Tsui KH, Wu MY, Lin LT, Wen ZH, Li YH, Chu PY*, Li CJ*. Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms. Theranostics. 9:6631. IF – 8.063. (Cover story). 2019.
    5. Li CJ, Chu PY, Yiang GT, Wu MY. The molecular mechanism of epithelial-mesenchymal transition for breast carcinogenesis. Biomolecules. 9:E476. IF – 4.694. 2019.
    6. Wang CN, Li CY, Cai JH, Sheu CY, Tsai JP, Wu MY, Li CJ*, Hou MF*. Identification of prognostic candidate genes in breast cancer by integrated bioinformatic Analysis. J Clin Med. 8:1160. IF – 5.688. 2019.
    7. Liao WT, Su CC, Lee MT, Li CJ, Lin CL, Chiang JH, Yen HR. Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study. J Ethnopharmacol. 243:112091. IF – 3.414. 2019.
    8. Ko CJ, Li CJ, Wu MY, Chu PY. Overexpression of LGR-5 as a predictor of poor outcome in patients with hepatocellular carcinoma. J Environ Res Public Health. 16:1836. IF – 2.468. 2019.
    9. Chen SN, Chang R, Lin LT, Chern CU, Tsai HW, Wen ZH, Li YH, Li CJ, Tsui KH. MicroRNA in ovarian cancer: biology, pathogenesis, and therapeutic opportunities. Int J Environ Res Public Health. 16:1510. IF – 2.468. 2019.
    10. Li CJ, Chen CS, Yiang GT, Tsai PY, Liao WT, Wu MY. Advanced evolution of pathogenesis concepts in cardiomyopathies. J Clin Med. 8:520. IF – 5.688. (Cover story). 2019.
    11. Chiu HC, Li CJ, Yiang GT, Tsai PY, Wu MY. EMT and cell biology of molecular regulation in endometrial carcinogenesis. J Clin Med. 8:439. IF – 5.688. 2019.
    12. Li CJ, Chen SN, Lin LT, Chern CU, Wang PH, Wen ZH, Tsui KH. DHEA modulates abnormal mitochondrial dynamics and mitophagy of cumulus Cells in poor ovarian responders. J Clin Med. 7:293. IF – 5.688. 2018.
    13. Lin YT, Wu YC, Sun GC, Ho CY, Wong TY, Lin CH, Chen HH, Yeh TC, Li CJ, Tseng CJ, Cheng PW. Effect of resveratrol on reactive oxygen species-induced cognitive impairment in rats with angiotensin II-induced early Alzheimer’s disease. J Clin Med. 7:329. IF – 5.688. 2018.
    14. Wu MY, Yiang GT, Chen YL, Li CJ*, Lin SC*. Clinical outcome and management for geriatric traumatic injury: analysis of 2688 cases in emergency department at a teaching hospital in Taiwan. J Clin Med. 7:255. IF –5.688. 2018.
    15. Wang SC, Wang SC, Li CJ, Lin CH, Huang HL, Tsai LM, Chang CH. The therapeutic effects of traditional Chinese medicine for poor semen quality in infertile males. J Clin Med. 7:239. IF – 5.688. 2018.
    16. Wu MY, Chen CS, Yiang GT, Cheng PW, Chiu HC, Liu KH, Lee WC, Li CJ*. The molecular regulation in the pathogenesis of IgA nephropathy. J Clin Med. 7:225. IF – 5.688. 2018.
    17. Wu MY, Yiang GT, Lai TT, Li CJ*. The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med and Cell Longev. 2018:3420187. IF – 4.868. 2018.
    18. Wu MY, Yiang GT, Cheng PW, Chu PY, Li CJ*. Molecular targets in hepatocarcinogenesis and implications for therapy. J Clin Med. 7, 213. IF – 5.688. (Cover story). 2018.
    19. Chiu HC, Wu MY, Li CH, Huang SC, Yiang GT, Yen HS, Liu WL, Li CJ*, Kao WY*. EMT with malignant transformation leading multiple metastasis from leiomyomatosis peritonealis disseminata. J Clin Med. 7:207. IF –5 .688. 2018.
    20. Ko CJ, Li CJ, Wu MY, Chu PY. Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Exp Ther Med. 16:4810. IF – 1.448. 2018.
    21. Liao WT, Chiang JH, Li CJ, Lee MT, Su CC, Yen HR. Investigation on the use of traditional Chinese medicine for polycystic ovary syndrome in a nationwide prescription database in Taiwan. J Clin Med. 7:179. IF – 5.688. 2018.
    22. Wu MY, Lee LC, Chen YL, Yeh YH, Li CJ*, Yiang GT*. Septic pulmonary emboli or pulmonary metastasis in a patient with diabetes mellitus? J Clin Med. 7:176. IF – 5.688. 2018.
    23. Yang CY, Chen CS, Yiang GT, Cheng YL, Yong SB, Wu MY, Li CJ*. New insights into the immune molecular regulation of the pathogenesis of acute respiratory distress syndrome. Int J Mol Sci. 19:588. IF – 4.183. 2018.
    24. Wu MY, Yiang GT, Liao WT, Tsai PY, Cheng PW, Li CY, Li CJ*. Current concepts of the mechanism in ischemia and reperfusion injury. Cell Physiol Biochem. 46:1650. IF – 5.5. 2018.
    25. Wu MY#, Li CJ#, Yiang GT, Hou YT, Hou MF, Chu PY. # co-first. Molecular regulation of bone metastasis pathogenesis. Cell Physiol Biochem. 46:1423. IF – 5.5. 2018.
    26. Lin SC, Chu PY, Liao WT, Wu MY, Tsui KH, Chen LL, Li CJ*. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 39:703. IF – 3.041. 2018.
    27. Wu MY, Li CJ, MF Hou, Chu PY. New insights into the role of inflammation in the pathogenesis of atherosclerosis. Int J Mol Sci. 18:2034. IF – 4.183. 2017.
    28. Li CJ, Liao WT, Wu MY, Chu PY. New insights into the role of autophagy in tumor immune microenvironment. Int J Mol Sci. 18:1566. IF – 4.183. 2017.
    29. Lin LT, Chen JT, Chao KC, Li CJ, Tsui KH. Dehydroepiandrosterone as a potential agent to slow down ovarian aging. J Obstet Gynaecol Res. 43: 1855. IF – 1.099. 2017.
    30. Li CJ, Chen PK, LY Sun, Pang CY. Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Oxid Med and Cell Longev. 2017:851085. IF – 4.868. 2017.
    31. Lin LT, Wang PH, Wen ZH, Li CJ, Chen SN, Tsai EM, Cheng JT, Tsui KH. The application of DHEA on improving mitochondrial function and reducing apoptosis of cumulus cells in poor ovarian responders. Int J Med Sci. 14: 585. IF – 2.284. 2017.
    32. Tsui KH, Wang PH, Lin LT, Li CJ. DHEA protect mitochondria against dual modes of apoptosis and necroptosis in granulosa cells. Reproduction. 154:101. IF – 3.125. 2017.
    33. Lin LT, Wang PH, Chen SN, Li CJ, Wen ZH, Cheng JT, Tsui KH. Protection of cumulus cells following DHEA supplementation. Gynecol Endocrinol. 33: 100. IF – 1.585. 2016.
    34. Li CJ, LY Sun, Pang CY. Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Sci Rep. 5: 9819. IF – 4.122. 2015.
    35. Li CJ, Chu CY, Huang LH, Wang MH, Sheu LF, Yeh JI, Hsu HY. Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo. Cancer Lett. 319: 203. IF – 6.508. 2012.
    36. Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY. Momordica charantia-induced extract induces apoptosis in human cancer cells through caspase-dependent and mitochondria-dependent pathway. Evid Based Complement Alternat Med. 2012: 261971. IF – 2.064. 2012.
    37. Li CJ, Huang SY, Wu MY, Chen YC, Tsang SF, Chyuan JH, Hsu HY. Induction of apoptosis by ethanolic extract of Corchorus olitorius leaf in human hepatocellular carcinoma (HepG2) cells via a mitochondria dependent pathway. Molecules. 17: 9348. IF – 3.098. 2012.
    38. Tseng HL, Li CJ, Chen CY, Huang LH, Lin CN, Hsu HY. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicol Appl Pharmacol. 264: 104. IF – 3.705. 2012.
    39. Hsu HY, Lin JH, Li CJ, Tsang SF, Tsai CH, Chyuan JH, Chiu SJ, Chuang SE. Anti-migratory effects of the methanol-extract from Momordica charantia on human lung adenocarcinoma CL1 cells. Evid Based Complement Alternat Med. 2012: 819632. IF – 2.064. 2012.
    40. Huang WT, Li CJ, Wu PJ, Chang YS, Lee TL, Weng CF. Expression and in vitro regulation of pituitary adenylate cyclase-activating polypeptide (PACAP38) and its type I receptor (PAC1-R) in the gonads of tilapia (Oreochromis mossambicus). Reproduction. 137: 449. IF – 3.125. 2009.

     

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