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李佳榮 博士

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    資料來源:臨床醫學研究科       

    學經歷

    1. 高榮婦女醫學部 副研究員 (2019.02-) 
    2. 國立中山大學生技醫藥研究所 合聘副教授 (2020-)
    3. 教育部頒定助理教授(助字第149431號) (2020.03-)
    4. 秀傳紀念醫院醫研部 研究員兼組長 (2017.02-2019.02)  
    5. 秀傳醫學雜誌執行編輯 (2017.07-2019.01)
    6. 國立成功大學臨床醫學研究所 博士後研究員 (2015.08-2017.02)
    7. 慈濟大學 醫學科學研究所 博士 (2008.09-2015.07)
    8. 中央研究 細胞與個體生物學研究所 (2006.06-2007.12)

    Art editor Img

    The mitochondrion receives most recognition for its role in generating energy for cells in the body and they are commonly referred to as the powerhouse. Energy flow through our cells is largely driven by mitochondria, which in turn give us the ability to sense and perceive, integrate information, and adapt to stressors. Our research team combines knowledge from mitochondrial biology, reproductive endocrinology, aging, computational bioinformatics, and mitochondrial medicine to understand principles of mitochondrial communication and signal transduction. We deployed a mitochondrial phenotype analysis platform with our collaborators to map mitochondrial morphological differences and individual differences, understand mitochondrial plasticity over time, and map its role in human health and aging maintenance on various diseases.

    主編:

    1. Journal of Personalized Medicine (IF: 4.945; 2021)

    -Special Issue: Advances in the Research of Endocrine and Metabolic Disorders in the Human Reproductive System

    1. Journal of Personalized Medicine (IF: 4.945; 2021)

    -Special Issue: Precision Medicine in Breast Cancer: Challenges and Opportunities in Diagnostic and Therapeutic Purposes

    1. Journal of Visualized Experiments (IF: 1.355; 2021)

    -Special Issue: Methods Collections-Current research in mitochondrial medicine

    1. Biomedicines (IF: 6.081; 2021)

    -Special Issue: Mitochondrial Dysfunction and Oxidative Stress in Aging and Disease

    1. Oxidative Medicine and Cellular Longevity (IF: 6.543; 2020)

    -Special Issue: Infertility and Assisted Reproduction: the Impact of Oxidative Stress

    1. Cancer Control (IF: 3.103; 2020)

    -Special Issue: Molecular Bases of Carcinogenesis

    1. Biomolecules (IF: 4.694; 2019)

    -Special Issue: Oxidative Stress and Mitochondrial Dysfunction in Human Diseases: Pathophysiology, Predictive Biomarkers, Therapeutic

    1. Journal of Oncology (IF: 4.593; 2018)

    -Special Issue: Diagnostic, Prognostic and Predictive Biomarkers in Breast Cancer

     

    期刊審查委員

    Trends in Genetics (IF: 11.639)

    Journal of Experimental & Clinical Cancer Research (IF: 11.176)

    Ageing Research Reviews (IF: 10.895)

    Journal of Advanced Research (IF: 10.479)

    Cancers (IF: 6.639)

    Antioxidants (IF: 6.312)

    International Journal of Molecular Sciences (IF: 5.923)

    Aging (IF: 5.682)

    Nutrients (IF: 5.717)

    iScience (IF: 5.458)

    Biomolecules (IF: 4.879)

    Molecules (IF: 4.411)

    Journal of Oncology (IF: 4.375)

    Cancer Biology & Medicine (IF: 4.248)

    Journal of Clinical Medicine (IF: 4.241)

    OncoTargets and Therapy (IF: 4.147)

    Neurotoxicity Research (IF: 3.911)

    International Journal of Environmental Research and Public Health (IF: 3.390)

    Medical Science Monitor (IF: 2.649)

    Experimental Biology and Medicine (IF: 2.691)

    Evidence-Based Complementary and Alternative Medicine (IF: 2.629)

    Cells Tissues Organs (IF: 2.481)

    2021/10獲選台北國際乳癌研討會優秀論文獎

    2021/04 受邀至菲律賓國際亞太生殖醫學研討會(ASPIRE)大會講者

    2020/12獲選乳癌防治基金會優秀論文獎

    2020/11獲選粒線體研討會傑出論文獎

    2020/10獲選台北乳癌國際學術年會優秀論文獎

    2020/08獲選生殖醫學年會口頭論文競賽優秀獎

    2019/11 獲選乳癌防治基金會(TBCF)優秀論文獎

    2019/09論文獲選為該期封面故事 Theranostics (IF: 11.566). Vol:9, Issue:22.

    2019/08 獲選生殖醫學年會(TSRM)口頭論文競賽第一名

    2019/07 受邀至台灣醫事檢驗年會大會講者

    2019/04論文獲選為該期封面故事 J Clin Med. (IF: 5.688). Vol:8, Issue:4.

    2019/01 受邀至台南市立醫院全院性演講

    2018/10 獲選粒線體醫學年會(TSMRM)傑出論文獎

    2018/08論文獲選為該期封面故事 J Clin Med. (IF: 5.688). Vol:7, Issue:8.

    2018/06 受邀至台中慈濟醫院醫研部演講

    2017/11 受邀為粒線體醫學年會(TSMRM)大會講者

    2017/08 受邀至台南市立醫院全院性演講

    2016/11 獲科技部補助專家學者出席國際會議

    2016/10 獲細胞分子生物學會補助專家學者出席國際會議

    2015/09 受邀為中國南京國際生醫工程與製藥科學年會(ICBEPS)國際會議大會講者

    2014/11 獲選亞洲粒線體醫學年會(ASMRM)傑出論文獎

    2014/11 獲選慈濟學術會議優秀論文獎

    2012/10 獲選粒線體醫學年會(TSMRM)傑出論文獎

    2012/10 獲細胞分子生物學會補助專家學者出席國際會議

    2011/07 獲波士頓腫瘤休眠研討補助專家學者出席國際會議

     

    1. Wen CY, KH Tsui, CH Chang, YH Chiu, SC Lin, CY Chu, Li CJ*. Integrative Multi-Omics Analysis of Identified IDH1 Metabolic Enzyme as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Prostate Adenocarcinoma. J Oncol. 2021:9854799. IF: 4.375. 2022.
    2. Li CJ, Lin LT, Tsai HW, Wen ZH, Tsui KH. Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. Aging cell. e13546. IF: 9.304. 2022.
    3. Tsai HW, Li CJ, Lin LT, Chiang AJ, Chen SN, Wen ZH, Tsui KH. Expression Status and Prognostic Significance of Mitochondrial Dynamics OPA3 in Human Ovarian Cancer. Aging. Under review. IF: 5.682. 2022.
    4. Chu PY, Tzeng YD, Chiu YT, Lin HY, Chiu YH, Hou MF, Li CJ*. Downregulation of ATP Binding Cassette Subfamily A Member 10 Acts as a Prognostic Factor Associated with Immune Infiltration in Breast Cancer. Aging. In revision. IF: 5.682. 2022.
    5. Tzeng YD, Sheu JC, Tsui WL, Li CJ*. Integrated analysis of pivotal biomarker, immune cell infiltration and therapeutic drugs for LSM1-mutated in breast cancer. Front Mol Biosci. Under review. IF: 5.246. 2022.
    6. Liao WT, Chu PY, Huang MS, Tsui WL, Chiu YT, Wu CC, Li CJ*. Identifying the Prognostic Significance of Mitochondrial AAA Proteases YME1L1 Expression in Ovarian Cancer. Journal of Ovarian Research. Under review. IF: 4.234. 2022.
    7. Hou YL, Li CJ, Lin LT, Chen SN, Wen ZH and Tsui KH. DHEA Restores Mitochondrial Dynamics of Cumulus Cells by Regulating PGAM5 Expression in Poor Ovarian Responders. Taiwan J Obstet Gynecol. In press. IF: 1.705. 2021.
    8. Chu PY, Tzeng YD, Chiu YH, Lin HY, Kuo CH, Hou MF, Li CJ*. Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer. Biomedicines. 9:1329. IF: 6.081. 2021.
    9. Chiu YH, Lin SC, Kuo CH, Li CJ*. Molecular machinery and pathophysiology of mitochondrial dynamics. Front. Cell Dev. Biol. 9:743892. IF: 6.684. 2021.
    10. Tsai HW, Liao PF, Li CJ, Lin LT, Wen ZH, Tsui KH. High serum anti-Mullerian hormone levels have a negative impact on fertilization and embryo development rates in women undergoing assisted reproductive technology treatment. Reprod Biomed Online. S1472-6483(21)00413-2. IF: 3.822. 2021.
    11. Li CJ, Chiu YH, Chang C, Chang YC, Sheu JC, Chiang AJ. Acetyl coenzyme A synthase 2 acts as a prognostic biomarker associated with immune infiltration in cervical squamous cell carcinoma. Cancers. 13:3125. IF: 6.639. 2021.
    12. Li CJ, Lin LT, Tsui KH. Dehydroepiandrosterone shifts energy metabolism to increase mitochondrial biogenesis in female fertility with advancing age. Nutrients. 13:2449. IF: 5.717. 2021.
    13. Li CJ, Lin LT, Tsai HW, Chern CU, Wen ZH, Wang PH, Tsui KH. The molecular regulation in the pathophysiology in ovarian aging. Aging Dis. 12:934. IF: 6.745. 2021.
    14. Li CJ, Tzeng YD, Chiu YH, Lin HY, Hou MF, Chu PY. Pathogenesis and potential therapeutic targets for triple negative breast cancer. Cancers. 13:2978. IF: 6.639. 2021.
    15. Li CJ, Lin LT, Chu PY, Chiang AJ, Tsai HW, Chiu YH, Huang MS, Wen ZH, Tsui KH. Identification of novel biomarkers and candidate drug in ovarian cancer. J. Pers. Med. 11:316. IF: 4.945. 2021.
    16. Lin LT, Li CJ, Tsui KH. Serum testosterone levels are positively associated with serum anti-mullerian hormone levels in infertile women. Sci Rep. 11:6336. IF: 4.379. 2021.
    17. Yang YL, Chang YH, Li CJ, Huang YH, Tsai MC, Chu PY, Lin HY. New insights into the role of miR-29a in hepatocellular carcinoma: implications in mechanisms and theragnostics. J. Pers. Med. 11:219. IF: 4.945. 2021.
    18. Li CJ, Lin LT, Hou MF, Chu PY. PD-L1/PD-1 blockade in breast cancer: the immunotherapy Era. Oncol Rep. 45:5. IF: 3.906. 2021.
    19. Chiang AJ, Li CJ, Chang C, Chang YI, Cheng LW, Chang TH, Sheu JJ. UBE2C drives human cervical cancer progression and is positively modulated by mTOR. Biomolecules. 11:37. IF: 4.879. 2021.
    20. Chen YC, Li JY, Li CJ, Tsui KH, Wang PH, Wen ZH and Lin LT. Luteal phase ovarian stimulation versus follicular phase ovarian stimulation results in different human cumulus cell genes expression: A pilot study. Int. J. Med. Sci. 18: 1600. IF: 3.738. 2021.
    21. Li CJ, Tsui KH. Enhancement of human granulosa cells self-rescue by mitochondrial transfer via tunneling nanotubes. Fertil. Steril. 114:e350. IF: 7.329. 2020.
    22. Tsui KH, Li CJ. CREB1 integrates the metabolic and growth networks associated with the aging of human granulosa cells. Fertil. Steril. 114:e426. IF: 7.329. 2020.
    23. Tsui KH, Li CJ. Programmed mitophagy is essential for the glycolysis switching during senescence in human cumulus cells. Fertil. Steril. 114:e355. IF: 7.329. 2020.
    24. Lin LT, Li CJ. High expression of PGAM family member 5 (PGAM5) is associated with diminished ovarian responder in cumulus cells. Fertil. Steril. 114:e224. IF: 7.329. 2020.
    25. Lin LT, Li CJ. MitoQ shifts energy metabolism to increase biogenesis in human granulosa cells. Fertil. Steril. 114:e357. IF: 7.329. 2020.
    26. Lin HY, Li CJ, Yang YL, Huang YH, Hsiau YT, Chu PY. Role of lysyl oxidase family members in tumor microenvironment and progression of liver cancer. Int J Mol Sci. 21:9751. IF: 5.923. 2020.
    27. Li JY, Li CJ, Lin LT, Tsui KH. Multi-omics analysis identifying key biomarkers in ovarian cancer. Cancer Control. 27:1073274820976671. IF: 3.302. 2020.
    28. Li CJ. Oxidative Stress and Mitochondrial Dysfunction in Human Diseases: Pathophysiology, Predictive Biomarkers, Therapeutic. Biomolecules. 10:1558. IF: 4.879. 2020.
    29. Li CJ, Lin HY, Ko CJ, Lai JC, Chu PY. A Novel Biomarker Driving Poor-Prognosis Liver Cancer: Overexpression of the Mitochondrial Calcium Gatekeepers. Biomedicines. 8:E451. IF: 6.081. 2020.
    30. Peng NJ, C Hu, Chiu YL, Yu CC, Li CJ, Sheu JJ, Chiang AJ. Detection of Recurrent Cervical Cancer and Prediction of Its Patient Survival with Serum Squamous-Cell Carcinoma-Antigen and 2-[18 F] Fluoro-2-Deoxy-d-Glucose-Positron Emission Tomography/Computed Tomography. Diagnostics. 10:657. IF: 3.706. 2020.
    31. Wu MY, Lai TT, Liao WT, Li CJ*. Clinicopathological and prognostic significance and molecular mechanism in uveal melanoma. Ther Adv Med Oncol. 12:1. IF: 8.168. 2020.
    32. Lin PS, Lin LT, Li CJ, Kao PG, Tsai HW, Chen SN, Wen ZH, Wang PH, Tusi KH. Combining Bioinformatics and Experiments to Identify CREB1 as a Key Regulator in Senescent Granulosa Cells. Diagnostics. 10:295. IF: 3.706. 2020.
    33. Tsai HW, Wang PH, Hsu PT, Chen SN, Lin LT, Li CJ, Tsui KH. Laser irradiation pretreatment improves endometrial preparation of frozen-thawed embryo transfer in recurrent implantation failure patients. Gynecol Endocrinol. 13:1-5. IF: 2.260. 2020.
    34. Li CJ, Chen HM, Lai JC. Diagnostic, prognostic, and predictive biomarkers in breast cancer. J Oncol. 2020:1835691. IF: 4.375. 2020.
    35. Tsui KH, Wu MY, Lin LT, Wen ZH, Li YH, Chu PY, Li CJ*. Disruption of mitochondrial homeostasis with artemisinin unravels anti-angiogenesis effects via auto-paracrine mechanisms. Theranostics. 9:6631. IF: 11.566. (Cover story). 2019.
    36. Li CJ, Chu PY, Yiang GT, Wu MY. The molecular mechanism of epithelial-mesenchymal transition for breast carcinogenesis. Biomolecules. 9:E476. IF: 4.879. 2019.
    37. Wang CN, Li CY, Cai JH, Sheu CY, Tsai JP, Wu MY, Li CJ*, Hou MF*. Identification of prognostic candidate genes in breast cancer by integrated bioinformatic Analysis. J Clin Med. 8:1160. IF: 4.241. 2019.
    38. Liao WT, Su CC, Lee MT, Li CJ, Lin CL, Chiang JH, Yen HR. Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study. J Ethnopharmacol. 243:112091. IF: 4.360. 2019.
    39. Ko CJ, Li CJ, Wu MY, Chu PY. Overexpression of LGR-5 as a predictor of poor outcome in patients with hepatocellular carcinoma. J Environ Res Public Health. 16:1836. IF: 3.390. 2019.
    40. Chen SN, Chang R, Lin LT, Chern CU, Tsai HW, Wen ZH, Li YH, Li CJ, Tsui KH. MicroRNA in ovarian cancer: biology, pathogenesis, and therapeutic opportunities. Int J Environ Res Public Health. 16:1510. IF: 3.390. 2019.
    41. Li CJ, Chen CS, Yiang GT, Tsai PY, Liao WT, Wu MY. Advanced evolution of pathogenesis concepts in cardiomyopathies. J Clin Med. 8:520. IF: 4.241. (Cover story). 2019.
    42. Chiu HC, Li CJ, Yiang GT, Tsai PY, Wu MY. EMT and cell biology of molecular regulation in endometrial carcinogenesis. J Clin Med. 8:439. IF: 4.241. 2019.
    43. Li CJ, Chen SN, Lin LT, Chern CU, Wang PH, Wen ZH, Tsui KH. DHEA modulates abnormal mitochondrial dynamics and mitophagy of cumulus Cells in poor ovarian responders. J Clin Med. 7:293. IF: 4.241. 2018.
    44. Lin YT, Wu YC, Sun GC, Ho CY, Wong TY, Lin CH, Chen HH, Yeh TC, Li CJ, Tseng CJ, Cheng PW. Effect of resveratrol on reactive oxygen species-induced cognitive impairment in rats with angiotensin II-induced early Alzheimer’s disease. J Clin Med. 7:329. IF: 4.241. 2018.
    45. Wu MY, Yiang GT, Chen YL, Li CJ*, Lin SC*. Clinical outcome and management for geriatric traumatic injury: analysis of 2688 cases in emergency department at a teaching hospital in Taiwan. J Clin Med. 7:255. IF: 4.241. 2018.
    46. Wang SC, Wang SC, Li CJ, Lin CH, Huang HL, Tsai LM, Chang CH. The therapeutic effects of traditional Chinese medicine for poor semen quality in infertile males. J Clin Med. 7:239. IF: 4.241. 2018.
    47. Wu MY, Chen CS, Yiang GT, Cheng PW, Chiu HC, Liu KH, Lee WC, Li CJ*. The molecular regulation in the pathogenesis of IgA nephropathy. J Clin Med. 7:225. IF: 4.241. 2018.
    48. Wu MY, Yiang GT, Lai TT, Li CJ*. The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med and Cell Longev. 2018:3420187. IF: 6.543. 2018.
    49. Wu MY, Yiang GT, Cheng PW, Chu PY, Li CJ*. Molecular targets in hepatocarcinogenesis and implications for therapy. J Clin Med. 7, 213. IF: 4.241. (Cover story). 2018.
    50. Chiu HC, Wu MY, Li CH, Huang SC, Yiang GT, Yen HS, Liu WL, Li CJ*, Kao WY*. EMT with malignant transformation leading multiple metastasis from leiomyomatosis peritonealis disseminata. J Clin Med. 7:207. IF: 4.241. 2018.
    51. Ko CJ, Li CJ, Wu MY, Chu PY. Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Exp Ther Med. 16:4810. IF: 2.447. 2018.
    52. Liao WT, Chiang JH, Li CJ, Lee MT, Su CC, Yen HR. Investigation on the use of traditional Chinese medicine for polycystic ovary syndrome in a nationwide prescription database in Taiwan. J Clin Med. 7:179. IF: 4.241. 2018.
    53. Wu MY, Lee LC, Chen YL, Yeh YH, Li CJ*, Yiang GT*. Septic pulmonary emboli or pulmonary metastasis in a patient with diabetes mellitus? J Clin Med. 7:176. IF: 4.241. 2018.
    54. Yang CY, Chen CS, Yiang GT, Cheng YL, Yong SB, Wu MY, Li CJ*. New insights into the immune molecular regulation of the pathogenesis of acute respiratory distress syndrome. Int J Mol Sci. 19:588. IF: 5.923. 2018.
    55. Wu MY, Yiang GT, Liao WT, Tsai PY, Cheng PW, Li CY, Li CJ*. Current concepts of the mechanism in ischemia and reperfusion injury. Cell Physiol Biochem. 46:1650. IF: 5.5. 2018.
    56. Wu MY#, Li CJ#, Yiang GT, Hou YT, Hou MF, Chu PY. # co-first. Molecular regulation of bone metastasis pathogenesis. Cell Physiol Biochem. 46:1423. IF: 5.5. 2018.
    57. Lin SC, Chu PY, Liao WT, Wu MY, Tsui KH, Chen LL, Li CJ*. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 39:703. IF: 3.906. 2018.
    58. Wu MY, Li CJ, MF Hou, Chu PY. New insights into the role of inflammation in the pathogenesis of atherosclerosis. Int J Mol Sci. 18:2034. IF: 5.923. 2017.
    59. Li CJ, Liao WT, Wu MY, Chu PY. New insights into the role of autophagy in tumor immune microenvironment. Int J Mol Sci. 18:1566. IF: 5.923. 2017.
    60. Lin LT, Chen JT, Chao KC, Li CJ, Tsui KH. Dehydroepiandrosterone as a potential agent to slow down ovarian aging. J Obstet Gynaecol Res. 43: 1855. IF: 1.730. 2017.
    61. Li CJ, Chen PK, LY Sun, Pang CY. Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Oxid Med and Cell Longev. 2017:851085. IF: 6.543. 2017.
    62. Lin LT, Wang PH, Wen ZH, Li CJ, Chen SN, Tsai EM, Cheng JT, Tsui KH. The application of DHEA on improving mitochondrial function and reducing apoptosis of cumulus cells in poor ovarian responders. Int J Med Sci. 14: 585. IF: 3.738. 2017.
    63. Tsui KH, Wang PH, Lin LT, Li CJ. DHEA protect mitochondria against dual modes of apoptosis and necroptosis in granulosa cells. Reproduction. 154:101. IF: 3.906. 2017.
    64. Lin LT, Wang PH, Chen SN, Li CJ, Wen ZH, Cheng JT, Tsui KH. Protection of cumulus cells following DHEA supplementation. Gynecol Endocrinol. 33: 100. IF: 1.585. 2016.
    65. Li CJ, LY Sun, Pang CY. Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Sci Rep. 5: 9819. IF: 4.379. 2015.
    66. Li CJ, Chu CY, Huang LH, Wang MH, Sheu LF, Yeh JI, Hsu HY. Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo. Cancer Lett. 319: 203. IF: 8.679. 2012.
    67. Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY. Momordica charantia-induced extract induces apoptosis in human cancer cells through caspase-dependent and mitochondria-dependent pathway. Evid Based Complement Alternat Med. 2012: 261971. IF: 2.630. 2012.
    68. Li CJ, Huang SY, Wu MY, Chen YC, Tsang SF, Chyuan JH, Hsu HY. Induction of apoptosis by ethanolic extract of Corchorus olitorius leaf in human hepatocellular carcinoma (HepG2) cells via a mitochondria dependent pathway. Molecules. 17: 9348. IF: 4.411. 2012.
    69. Tseng HL, Li CJ, Chen CY, Huang LH, Lin CN, Hsu HY. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicol Appl Pharmacol. 264: 104. IF: 4.219. 2012.
    70. Hsu HY, Lin JH, Li CJ, Tsang SF, Tsai CH, Chyuan JH, Chiu SJ, Chuang SE. Anti-migratory effects of the methanol-extract from Momordica charantia on human lung adenocarcinoma CL1 cells. Evid Based Complement Alternat Med. 2012: 819632. IF: 2.630. 2012.
    71. Huang WT, Li CJ, Wu PJ, Chang YS, Lee TL, Weng CF. Expression and in vitro regulation of pituitary adenylate cyclase-activating polypeptide (PACAP38) and its type I receptor (PAC1-R) in the gonads of tilapia (Oreochromis mossambicus). Reproduction. 137: 449. IF: 3.906. 2009

       

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