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楊明慧 博士

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    資料來源:臨床醫學研究科       

    學歷:

    博士 Texas Christian University, Department of Chemistry

    碩士 University of Texas at Dallas, Department of Chemistry

    學術經歷:

    1. 高雄榮民總醫院教學研究部高級助理研究員 (2020迄今)

    2. 國家衛生研究院國家蚊媒傳染病防治研究中心博士後研究員

    3. 高雄醫學大學傳染病與癌症研究中心博士後研究員/研究助理教授

    4. 國立雲林科技大學化學工程與材料工程系博士後研究員

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    1. Ming-Hui Yang, Marcelo Chen, Hsiao-Hsuan Mo, Wan-Chi Tsai, Yu-Chi Chang, Chin-Chuan Chang, Ko-Chin Chen, Hsin-Yi Wu, Cheng-Hui Yuan, Che-Hsin Lee, Yi-Ming Arthur Chen*, Yu-Chang Tyan*. Utilizing experimental mouse model to identify effectors of hepatocellular carcinoma induced by HBx antigen, Cancers, 12(2). pii: E409, 2020. (IF=6.162, 31/130, 23.85 %, Oncology)
    2. Yu-Chang Tyan, Ming-Hui Yang, Chin-Chuan Chang, Tze-Wen Chung*. Biocompatibility of Materials for Biomedical Engineering. Advances in Experimental Medicine and Biology, in press, 2020 (IF=2.126, 30/87, 34.48%, Biology).
    3. Ming-Hui Yang+, Shih-Cheng Chen, Ko-Chin Chen+, Han-Ping You, Hsin-Yi Wu, Yi-Ming Chen, Ying-Fong Huang, Ming-Yii Huang, Cheng-Hui Yuan, Po-Chiao Lin, Yu-Chang Tyan*. Quantitative analysis of progesterone using isotope dilution matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for radioimmunoassay. Clinica Chimica Acta, in press, 2020 (IF=2.735, 8/29, 27.59 %, Medical laboratory technology)
    4. Ming-Hui Yang, Chen-Chung Liao, Jung-Hsien Hung, Xiu-Ting Lai, Chia-Hung Yen* and Yi-Ming Arthur Chen* Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene. Journal of Food and Drug Analysis, 27(2), 603-9, 2019. (IF=4.176, 13/135, 9.63 %, Food science & technology).
    5. Marcelo Chen+, Ming-Hui Yang+(co-first author), Ming-Min Chang, Yu-Chang Tyan, Yi-Ming Arthur Chen*. Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma. Toxicology and Applied Pharmacology, 378,114607, 2019. (IF= 3.585, 21/93, 22.58%, Toxicology).
    6. Ming-Hui Yang, Shih-Cheng Chen, Yu-Fen Lin, Yi-Chia Lee, Ming-Yii Huang, Ko-Chin Chen, Hsin-Yi Wu, Po-Chiao Lin, Illana Gozes* and Yu-Chang Tyan*. Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease. Journal of Food and Drug Analysis, 27(2), 551-64, 2019. ( IF=4.176, 13/135, 9.63 %, Food science & technology).
    7. Ming-Hui Yang, Chia-Hung Yen, Yen-Fu Chen, Cheng-Chieh Fang, Chung-Hsien Li, Kuo-Jui Lee, Yi-Hsiung Lin, Chien-Hui Weng, Tze-Tze Liu, Shiu-Feng Huang, Bin Tean Teh and Yi-Ming Arthur Chen*. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Scientific Reports, 9(1), 2552, 2019. (IF=4.011, 15/69, 21.74%, multidisciplinary sciences).
    8. Ming-Hui Yang, Wan-Jou Chen, Yaw-Syan Fu, Bin Huang, Wan-Chi Tsai, Yi-Ming Arthur Chen, Po-Chiao Lin, Cheng-Hui Yuan and Yu-Chang Tyan*. Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma. Oncotarget, 9(1), 442-452, 2018 (IF=5.168, 44/217, 20.28%, Oncology).
    9. Shih-Cheng Chen+, Ming-Hui Yang+(co-first author), Tze-Wen Chung, Ting-Syuan Jhuang, Jean-Dean Yang, Ko-Chin Chen, Wan-Jou Chen, Ying-Fong Huang, Shiang-Bin Jong, Wan-Chi Tsai, Po-Chiao Lin and Yu-Chang Tyan*. Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International, Volume 2017, Article ID 4051763, 8 pages, 2017 (IF=2.197, 94/162, 58.02%, Biotechnolohy & applied microbiology).
    10. Ming-Hui Yang+, Ko-Chin Chen+, Pei-Wen Chiang, Wan-Jou Chen, Pei-Yu Chu, Sharon Chen, Yi-Shan Lu, Cheng-Hui Yuan, Ming-Chen Wang, Chia-Yang Lin, Ying-Fong Huang, Shiang-Bin Jong, Po-Chiao Lin, Tze-Wen Chung and Yu-Chang Tyan*. Proteomic profiling of neuroblastoma cells adhesion on hyaluronic acid-based surface for neural tissue engineering. BioMed Research International, Volume 2016, Article ID 1917394, 13 pages, 2016 (IF=2.197, 94/162, 58.02%, Biotechnolohy & applied microbiology).
    11. Chun-Hao Tsai+, Ming-Hui Yang+(co-first author), Amos Hung, Shou-Cheng Wu, Wen-Chin Chiu, Ming-Feng Hou, Yu-Chang Tyan, Yun-Ming Wang, Shyng-Shiou Yuan*. Id1 is a downstream effector for arsenic-promoted angiogenesis via PI3K/Akt, NF-κB and NOS signaling. Toxicology Research, 5,151-159, 2016. (IF=1.593, 83/93, 89.25%,  toxicology).
    12. Ming-Hui Yang, Tze-Wen Chung, Yi-Shan Lu, Yi-Ling Chen, Wan-Chi Tsai, Shiang-Bin Jong, Shyng-Shiou Yuan, Pao-Chi Liao, Po-Chiao Lin, Yu-Chang Tyan*. Activation of the Ubiquitin Proteasome Pathway by Silk Fibroin Modified Chitosan Nanoparticles in Hepatic Cancer Cells. Int. J. Mol. Sci., 16, 1657-1676, 2015. (IF=4.183, 78/299, 26.09% Biochemistry & molecular biology).
    13. Ming-Hui Yang, Shyng-Shiou F. Yuan, Tze-Wen Chung, Shiang-Bin Jong, Chi Yu Lu, Wan-Chi Tsai, Wen-Cheng Chen, Po-Chiao Lin, Pei-Wen Chiang, Yu-Chang Tyan. Characterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials. BioMed Research International. 2014:209469, 2014. (IF=2.706, 53/165, 32.12%,, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
    14. Ming-Hui Yang, Shyng-Shiou Yuan, Ying-Fong Huang, Po-Chiao Lin, Chi-Yu Lu, Tze-Wen Chung and Yu-Chang Tyan. A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells – Is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway?. BioMed Research International. 2014:789591, 2014. (IF=2.706, 53/165, 32.12%, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
    15. Ming-Hui Yang, Hsien-Yi Wang, Chi Yu Lu, Wan-Chi Tsai, Po-Chiao Lin, Shih-Bin Su and Yu-Chang Tyan*. Proteomic profiling for peritoneal dialysate: Differential protein expression in diabetes mellitus. BioMed Research International. 2013: 642964, 2013. (IF=2.88,50/160, 31.25% BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
    16. Y. C. Tyan+,*, M. H. Yang+(co-first author), T. W. Chung, C. Y. Lu, W. C. Tsai, S. B. Jong “Assessing human urinary proteome using a mass spectrometry-based profiling system combined with magnetic nanoparticles.” Clinica Chimica Acta, 420, 54-61, 2013 (SCI, IF=2.85, Rank=6/32,  19%, MEDICAL LABORATORY TECHNOLOGY).
    17. Y. C. Tyan*, S. B. Jong, M. H. Yang (co-first), T. L. Wu, T. W. Chung, P. C. Liao, C. Y. Lin, Y. F. Huang, “Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine.” Clinica Chimica Acta, 420, 99-103, 2013 (SCI, IF=2.85, Rank=6/32,  19%, MEDICAL LABORATORY TECHNOLOGY).
    18. M. H. Yang, A. Dibas, Y. C. Tyan*, “Changes in retinal aquaporin-9 (AQP9) expression in glaucoma.” Bioscience Reports, 33 (2), 379-385, 2013. (SCI, IF= 1.876, Rank=141/185, 76%, CELL BIOLOGY).
    19. M. H. Yang, S. B. Jong, C. Y. Lu, Y. F. Lin, P. W. Chiang, Y. C. Tyan*, T. W. Chung*. “Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing mass spectrometry-based profiling system: over-expression of CD36, CD44, CDK9, and PP2A” Analyst, 137, 4921-4933, 2012. (Journal’s cover story, hot article)  (SCI, IF=4.230, Rank=8/73, 11%,  CHEMISTRY, ANALYTICAL).
    20. M. H. Yang, Y. H. Yang, C. Y. Lu, S. B. Jong, L.J. Chen, Y. F. Lin, S. J. Wu, P. Y. Chu, T. W. Chung, Y. C. Tyan*, “Activity-dependent neuroprotector homeobox protein: a candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease” Journal of Proteomics, 75, 3617-29, 2012. (SCI, IF=4.878, Rank=12/72, 17%, BIOCHEMICAL RESEARCH METHODS)
    21. Y. C. Tyan*, M. H. Yang (co-first author), C. J. Chen, S. B. Jong, W. C. Chen, Y. H. Yang, T. W. Chung, P. C. Liao, “Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma” Rapid Communications in Mass Spectrometry, 25, 2851-62, 2011. (SCI, IF=2.846, Rank=19/73, 20.4%, CHEMISTRY, ANALYTICAL).
    22. M. H. Yang, P. Y. Chu, C. J. Chen, W. C. Chen, T. W. Chung, L. B. Tan, W. C. Kan, H. Y. Wang, S. B. Su, Y. C. Tyan*, “Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.” Biochemical and Biophysical Research Communications, 411, 714-720, 2011. (SCI, IF=2.595, Rank=38/73, 52.05%, BIOPHYSICS).
    23. M. H. Yang, R. R. Krishnamoorthy, S. B. Jong, P. Y. Chu, Y. H. Yang, W. C. Chen, C. J. Chen, A. Dibas, T. Yorio, T. W. Chung*, Y. C. Tyan*, “Protein profiling of human non-pigmented ciliary epithelium cell secretome - the differentiation factors characterization for retinal ganglion cell-line.” Journal of Biomedicine and Biotechnology, 2011, 1-28, 2011. (SCI, IF=1.230, Rank=111/160, 69.3%, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
    24. Y. C. Tyan*, M. H. Yang (co-first author), T. W. Chung, W. C. Chen, M. C. Wang, Y. L. Chen, J. L. Huang, Y. F. Huang, S. B. Jong*, “Characterization of surface modification on self-assembled monolayer-based piezoelectric crystal immunosensor for the quantification of serum alpha - fetoprotein.” Journal of Materials Science: Materials in Medicine, 22, 1383-1391, 2011. (SCI, IF=2.325, Rank=20/70, 28.57%, ENGINEERING, BIOMEDICAL).
    25. M. H. Yang, L. H. Lo, Y. H. Chen, J. Shiea*, P. C. Wu, Y. C. Tyan, Y. J. Jong, “Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.” Rapid Communications in Mass Spectrometry, 23, 3220-3226, 2009. (SCI, IF=2.846, Rank=19/73, CHEMISTRY, ANALYTICAL).
    26. Y. C. Tyan, M. H. Yang, S. B. Jong, C. K. Wang, J. Shiea, “Melamine contamination.” Analytical and Bioanalytical Chemistry, 395, 729-735, 2009. (SCI, IF=3.841, Ranking: 9/73, CHEMISTRY, ANALYTICAL).
    27. A. Dibas*, M. H. Yang, S. He, J. Bobich, T. Yorio, “Changes in ocular aquaporin-4 (AQP4) expression following retinal injury.” Molecular Vision 14:1770-1783, 2008. (SCI, IF=2.511, Ranking=14/56, OPHTHALMOLOGY).
    28. P. P Lin, M. H. Yang, P. C. Liao, H. Y. Wu, L. W. Chang, H. T. Tsai, Y. C. Tyan*, “Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells.” Biochemical and Biophysical Research Communications 376: 519-524, 2008. (SCI, IF=2.595, Rank=38/73, BIOPHYSICS).
    29. Y. W. Liu, M. H. Yang, P. Y. Liu, C. H. Lee, P. C. Liao, Y. C. Tyan*, “Proteomic analysis of pericardial effusion: characteristic of tuberculosis-related proteins.” Proteomics Clin. Appl. 2: 458-466, 2008. (SCI, IF=1.514, Ranking=49/65, Biochemical research methods).
    30. M. H. Yang, Y. C. Tyan*, S. B. Jong, Y. F. Huang, P. C. Liao, M. C. Wang, “Identification of human hepatocellular carcinoma-related proteins by proteomic approaches” Analytical & Bioanalytical Chemistry 388: 637-643, 2007. (SCI, IF=3.841, Ranking=9/73, CHEMISTRY, ANALYTICAL).
    31. Y. C. Tyan*, M. H. Yang, P. C. Liao, J.D. Liao, S. B. Jong, C. Y. Liu, M. C. Wang, M. Grunze, “MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolayers: A preliminary application for protein sample analysis” International Journal of Mass Spectrometry 262: 67-72, 2007. (SCI, IF=2.337, Ranking=10/39, SPECTROSCOPY).
    32. A. Dibas*, M. H. Yang, J. Bobich, T. Yorio, “Stress-induced changes in neuronal Aquaporin-9 (AQP9) in a retinal ganglion cell-line” Pharmacological Research 55: 378-384, 2007. (SCI, IF=3.612, Ranking=56/252, PHARMACOLOGY & PHARMACY).
    33. M. H. Yang and M. C. Biewer*, “Monitoring surface reactions optically in a self-assembled monolayer with a photochromic core” Tetrahedron Letters 46:349-351, 2005. (SCI, IF=2.618, Ranking=20/56, CHEMISTRY, ORGANIC).
    34. M. H. Yang, J. D. Liao, S. B. Jong, P. C. Liao, C. Y. Liu, M. C. Wang, M. Grunze, Y. C. Tyan*, “Identification of human plasma proteins by trypsin immobilized digestion chip and electrospray ionization tandem mass spectrometry” Journal of Medical and Biological Engineering 25: 81-86, 2005. (SCI, IF=0.42, Ranking=63/70, ENGINEERING, BIOMEDICAL).
    1. The roles of PREX2 and its interacting proteins in liver cancer. The Asia Pacific Society for Biology and Medical Sciences 2019 Annual Meeting. (2019 July/ Sapporo, Japan)
    2. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. 2018. The 2nd Israel Taiwan International Medical Conference. (2018 Nov/ Kaohsiung, Taiwan)
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