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楊宜芳 博士

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    資料來源：臨床醫學研究科       

    學術經歷：

    高級助理研究員 高雄榮民總醫院 教學研究部 (2019~)

    醫學助理研究員 高雄醫學大學附設中和紀念醫院 轉譯醫學研究中心 (2016~2019)

    博士後研究員 成功大學  工業衛生學科暨環境醫學研究所(2015~2016)

     

    學歷

    1. 博士 陽明大學 生化暨分子生物學研究所 (2007/09~2014/09)
    2. 碩士 輔英科技大學 生物技術系 (2004/09~2006/06)

    Art editor Img

    2019  Poster Contest, Kaohsiung International Cancer Symposium (Taiwan), March 31,2019.

    2017  Semi-Finalist of the Young Investigator Competition of the University of Cologne-Kaohsiung Medical University Joint Symposium on Cancer, Infection, Aging, Neurodegeneration Kaohsiung, May, 2017

    2015  Masterpiece Award thesis, The Twenty-third Symposium on Recent Advances in Cellular and Molecular Biology(Taiwan),2015.

    2014  Highlights-Graduate Student Research in Pathology, American Society for Investigative Pathology (ASIP),USA.

    2013  Outstanding Poster, The Twenty-first Symposium on Recent Advances in Cellular and Molecular Biology (Taiwan).

    以整合基因體學的研究方式，分析暨有的基因資料庫等Omics資料庫，找出對癌細胞生長有利的代謝途徑，針對此代謝途徑找出治療的方向和方法。

    1. 之前我們的研究顯示，在轉移能力較強的肺癌細胞中，膽固醇新生合成的酵素有過度表現的狀況。其中包括SQS和降膽固醇用藥Statin所針對的HMG-CoA等。經過驗證，SQS脫穎而出，證實SQS的過度表現是一個可以用來預測肺癌病人不良預後的指標。同時，抑制這個酵素的活性更能有效抑制肺癌細胞的轉移。
    2. 在轉移能力較強的肺癌細胞exosome中，我們找到IMPAD1會將PAP轉化成AMP提供細胞新的訊息傳遞路徑以達到癌細胞轉移的目的。進一步透過臨床資料分析，IMPAD1的過度表現與淋巴轉移有關，是一個可以用來預測肺癌病人不良預後的指標。同時，抑制IMPAD1的表現能有效抑制肺癌細胞的轉移。
    1. Y.F. Yang, Y.Y. Wang, M. Hsiao, S. Lo, Y.C. Chang, Y.H. Jan, T.C. Lai, Y.C. Lee, Y.C. Hsieh, S.F. Yuan, IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway, Cancer letters, 485 (2020) 27-37. (25/217, Oncology, IF=7.3)
    2. Y.C. Chang#, Y.F. Yang#, J. Chiou, H.F. Tsai, C.Y. Fang, C.J. Yang, C.L. Chen, M. Hsiao, Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness, Cell Death Dis, 11 (2020) 195. (40/195, Cell biology, IF=6.3) (#co-1st author)
    3. Y.F. Yang, Y.C. Lee, Y.Y. Wang, C.H. Wang, M.F. Hou, S.F. Yuan, YWHAE promotes proliferation, metastasis, and chemoresistance in breast cancer cells, Kaohsiung J Med Sci, (2019). (115/136, Medicine, Research&Experimental, IF=1.291)
    4. Y.C. Chang, J. Chiou, Y.F. Yang, C.Y. Su, Y.F. Lin, C.N. Yang, P.J. Lu, M.S. Huang, C.J. Yang, M. Hsiao, Therapeutic Targeting of Aldolase A Interactions Inhibits Lung Cancer Metastasis and Prolongs Survival, Cancer research, (2019). (21/217, Oncology, IF=8.378)
    5. Y.F. Yang, Y.C. Lee, S. Lo, Y.N. Chung, Y.C. Hsieh, W.C. Chiu, S.F. Yuan, A positive feedback loop of IL-17B-IL-17RB activates ERK/beta-catenin to promote lung cancer metastasis, Cancer letters, 422 (2018) 44-55. (25/217, Oncology, IF=6.3)
    6. C.H. Wang, P.J. Wang, Y.C. Hsieh, S. Lo, Y.C. Lee, Y.C. Chen, C.H. Tsai, W.C. Chiu, S. Chu-Sung Hu, C.W. Lu, Y.F. Yang, C.C. Chiu, F. Ou-Yang, Y.M. Wang, M.F. Hou, S.S. Yuan, Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties, Oncogene, 37 (2018) 589-600. (21/217, Oncology, IF=7.5)
    7. C.W. Lu, Y.H. Lo, C.H. Chen, C.Y. Lin, C.H. Tsai, P.J. Chen, Y.F. Yang, C.H. Wang, C.H. Tan, M.F. Hou, S.F. Yuan, VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis, Cancer letters, 388 (2017) 130-138. (25/217, Oncology, IF=6.3)
    8. P.C. Lin#, Y.F. Yang#, Y.C. Tyan, E.S. Hsiao, P.C. Chu, C.T. Lee, J.C. Lee, Y.M. Chen, P.C. Liao, Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses, PloS one, 11 (2016) e0158844. (11/63, Multidisciplinary sciences, IF=3) (#co-1st author)
    9. H.Y. Wu, Y.G. Goan, Y.H. Chang, Y.F. Yang, H.J. Chang, P.N. Cheng, C.C. Wu, V.G. Zgoda, Y.J. Chen, P.C. Liao, Qualification and Verification of Serological Biomarker Candidates for Lung Adenocarcinoma by Targeted Mass Spectrometry, Journal of proteome research, 14 (2015) 3039-3050. (14/79, Biochemical research methods, IF=4.2)
    10. J.S. Chang, C.Y. Su, W.H. Yu, W.J. Lee, Y.P. Liu, T.C. Lai, Y.H. Jan, Y.F. Yang, C.N. Shen, J.Y. Shew, J. Lu, C.J. Yang, M.S. Huang, P.J. Lu, Y.F. Lin, M.L. Kuo, K.T. Hua, M. Hsiao, GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis, Oncotarget, 6 (2015) 36278-36291. (21/211, Oncology, IF=6.3)
    11. Y.F. Yang, Y.H. Jan, Y.P. Liu, C.J. Yang, C.Y. Su, Y.C. Chang, T.C. Lai, J. Chiou, H.Y. Tsai, J. Lu, C.N. Shen, J.Y. Shew, P.J. Lu, Y.F. Lin, M.S. Huang, M. Hsiao, Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis, American journal of respiratory and critical care medicine, 190 (2014) 675-687. (1/27, Critical care medicine, IF=11.9) (Selected for Cover Story)
    12. H.Y. Tsai, Y.F. Yang, A.T. Wu, C.J. Yang, Y.P. Liu, Y.H. Jan, C.H. Lee, Y.W. Hsiao, C.T. Yeh, C.N. Shen, P.J. Lu, M.S. Huang, M. Hsiao, Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78, Oncogene, 32 (2013) 4921-4931. (19/197, Oncology, IF=7.3) (#co-1st author)
    13. Y.H. Jan, H.Y. Tsai, C.J. Yang, M.S. Huang, Y.F. Yang, T.C. Lai, C.H. Lee, Y.M. Jeng, C.Y. Huang, J.L. Su, Y.J. Chuang, M. Hsiao, Adenylate kinase-4 is a marker of poor clinical outcomes that promotes metastasis of lung cancer by downregulating the transcription factor ATF3, Cancer research, 72 (2012) 5119-5129. (12/196, Oncology, IF=7.8)
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