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簡崇仁 教授
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    細胞藥理研究室 研究員 
    簡崇仁 (Chung-Ren Jan)

    學術經歷:

    高雄榮民總醫院 教學研究部 研究員 (2002/01迄今) 
    教育部頒定教授 (教字第011594號) (2001/07~) 
    輔英技術學院 兼任教授 (2000/03~2001/01) 
    國立中山大學 生物系 兼任教授 (1997/08~2002) 
    教育部頒定副教授(副字第025022號) (1997/02~) 
    國防醫學院 藥理系 兼任副教授(1997/02) 
    高雄榮民總醫院 教學研究部 副研究員 (199501~2002/01))

    學歷:

    美國紐約州奧伯尼醫學院藥理學博士

    Art editor Img

    1. 細胞內鈣離子測定螢光分光掃瞄儀
    2. CO2培養箱
    3. 無菌操作台
    4. 離心機
    5. 蛋白質電泳漕
    6. 蛋白質分析儀
    7. 聚合脢連鎖反應儀
    8. 冷凍離心機
    1. 即時定量聚合連鎖反應系統(real time PCR system)
    2. 聚合連鎖反應儀
    3. 倒立顯微鏡
    4. 核酸/蛋白質電泳槽
    5. 照膠影像系統
    6. 分光分析儀
    1. 89年度行政院全國傑出研究獎研究報告:鈣傳訊的調控
    2. 89年度SCI總公司(ISI) 台灣經典引文獎(2001.9.10)
    3. Reviewer of Journal of Neurochemistry (2001)
    4. Reviewer of Biochemical Pharmacology (2001)
    5. Reviewer of Life Sciences (2001)
    6. Reviewer of Journal of British Pharmacology (2003. Aug.)
    7. 89年度榮清陽計畫年度報告壁報組第一名
    8. 89年度中華藥理學會優秀論文獎
    9. 88年度嚴慶齡基礎科學研究獎
    10. 86, 88, 89, 92年度國科會甲種獎勵
    1. 研究各種臨床藥物對不同細胞株內鈣離子波動調控機制及鈣離子波動與細胞凋亡相關之研究。
    2. 偵測臨床檢體(不同病人之血小板、白血球或實驗動物受藥劑刺激之組織細胞)與鈣離子波動及藥理學之相關性。
    3. 研究各種臨床藥物對不同細胞株內鈣離子波動機制調控蛋白質表現之差異性。

    論文:
    . 原始著作 Articles:

    1. Cheng HH, Chou CT, Liang WZ*, Kuo CC, Shieh P*, Wang JL, Jan CR*. Effects of puerarin on intracellular Ca2+ and cell viability of MDCK renal tubular cells. Environ Toxicol Pharmacol. 2017 Mar 24;52:83-89. doi: 10.1016/j.etap.2017.03.015. [Epub ahead of print]
    2. Wang YH, Wang YC, Wu PH, Hsu L, Wang CY, Jan CR, Su HH*. A cross-sectional study into the correlation of common household risk factors and allergic rhinitis in Taiwan's tropical environment. Asian Pac J Trop Med. 2017 Feb;10(2):134-140. doi: 10.1016/j.apjtm.2017.01.012. Epub 2017 Jan 19.
    3. Yeh JH, Chou CT, Chen IS, Lu T, Lin KL, Yu CC, Liang WZ, Chang HT, Kuo CC, Ho CM, Chang WT, Shieh P*, Jan CR*. Effect of thymol on Ca²⁺ homeostasis and viability in PC3 human prostate cancer cells. Chin J Physiol. 2017 Feb 28;60(1):32-40.
    4. Su CK, Chou CT, Lin KL, Liang WZ, Cheng JS, Chang HT, Chen IS, Lu T, Kuo CC, Yu CC, Shieh P, Kuo DH, Chen FA, Jan CR*. Effect of protriptyline on [Ca2+]i and viability in MG63 human osteosarcoma cells. Toxicol Mech Methods. 2016 Oct;26(8):580-587.
    5. Chang HT, Chou CT, Chen IS, Yu CC, Lu T, Hsu SS, Shieh P, Jan CR, Liang WZ*. Mechanisms underlying effect of the mycotoxin cytochalasin B on induction of cytotoxicity, modulation of cell cycle, Ca2+ homeostasis and ROS production in human breast cells. Toxicology. 2016 Aug 31;370:1-19. doi: 10.1016/j.tox.2016.09.006.
    6. Cheng HH, Chou CT, Liang WZ, Cheng JS, Chang HT, Kuo CC, Chen IS, Lu T, Yu CC, Chen FA, Kuo DH, Shieh P, Jan CR*. Effect of NPC15199 on [Ca²⁺]i and Viability in SCM1 Human Gastric Cancer Cells. Chin J Physiol. 2016 Oct 31;59(5):268-275. doi: 10.4077/CJP.2016.BAF421.
    7. Wang JL, Chou CT, Liang WZ, Yeh JH, Kuo CC, Lee CY, Shieh P, Kuo DH, Chen FA, Jan CR*. Effect of 2,5-dimethylphenol on Ca2+ movement and viability in PC3 human prostate cancer cells. Toxicol Mech Methods. 2016 Jun;26(5):327-33. doi: 10.3109/15376516.2016.1158893. Epub 2016 Jun 16.
    8. Chen IS, Chou CT, Liu YY, Yu CC, Liang WZ, Kuo CC, Shieh P, Kuo DH, Chen FA, Jan CR*. The investigation of minoxidil-induced [Ca2+]i rises and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2016 Jun 16:1-7. [Epub ahead of print]
    9. Wang JL, Chou CT, Liu K, Liang WZ, Cheng JS, Chang HT, Chen IS, Lu T, Kuo CC, Yu CC, Shieh P, Kuo DH, Chen FA, Jan CR*. Ca2+ Signaling and Cell Death Induced by Protriptyline in HepG2 Human Hepatoma Cells. J Biochem Mol Toxicol. 2016 Nov;30(11):539-547. doi: 10.1002/jbt.21820. Epub 2016 Jun 2.
    10. Lee HH, Chou CT, Liang WZ, Chen WC, Wang JL, Yeh JH, Kuo CC, Shieh P, Kuo DH, Chen FA, Jan CR*. Ca²⁺ Movement Induced by Deltamethrin in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2016 Jun 30;59(3):148-55. doi: 10.4077/CJP.2016.BAE386.
    11. Hsu SS, Chou CT, Liao WC, Shieh P, Kuo DH, Kuo CC, Jan CR, Liang WZ. The effect of gallic acid on cytotoxicity, Ca2+ homeostasis and ROS production in DBTRG-05MG human glioblastoma cells and CTX TNA2 rat astrocytes. Chem Biol Interact. 2016 May 25;252:61-73. doi: 10.1016/j.cbi.2016.04.010. Epub 2016 Apr 7.
    12. Liang WZ, Chou CT, Cheng JS, Wang JL, Chang HT, Chen IS, Lu T, Yeh JH, Kuo DH, Shieh P, Chen FA, Kuo CC, Jan CR*. The effect of the phenol compound ellagic acid on Ca2+ homeostasis and cytotoxicity in liver cells. Eur J Pharmacol. 2016 Jun 5;780:243-51. doi: 10.1016/j.ejphar.2016.03.057. Epub 2016 Mar 30.
    13. Cheng JS, Chou CT, Liu YY, Sun WC, Shieh P, Kuo DH, Kuo CC, Jan CR, Liang WZ. The effect of oleuropein from olive leaf (Olea europaea) extract on Ca2+ homeostasis, cytotoxicity, cell cycle distribution and ROS signaling in HepG2 human hepatoma cells. Food Chem Toxicol 2016 Mar;91:151-66.
    14. Roan CJ, Chou CT, Liang WZ, Chang HT, Kuo DH, Kuo CC, Chen FA, Shieh P, Jan CR*. Effect of Miconazole on [Ca²+]i and Cytotoxicity in ZR-75-1 Human Breast Cancer Cells. Chin J Physiol. 2015 Dec 31;58(6):377-84.
    15. Chang HT, Chou CT, Lin YS, Shieh P, Kuo DH, Jan CR, Liang WZ*. Esculetin, a natural coumarin compound, evokes Ca2+ movement and activation of Ca2+-associated mitochondrial apoptotic pathways that involved cell cycle arrest in ZR-75-1 human breast cancer cells. Tumour Biol. 2015 Oct 28. [Epub ahead of print]
    16. Liang WZ, Liu PF, Fu E, Chung HS, Jan CR, Wu CH, Shu CW, Hsieh YD. Selective cytotoxic effects of low-power laser irradiation on human oral cancer cells. Lasers Surg Med. 2015 Nov;47(9):756-64. 
    17. Hung TY, Chou CT, Sun TK, Liang WZ, Cheng JS, Fang YC, Li YD, Shieh P, Ho CM, Kuo CC, Lin JR, Kuo DH, Jan CR*. The Mechanism of Safrole-Induced [Ca²]i Rises and Non-Ca²-Triggered Cell Death in SCM1 Human Gastric Cancer Cells. Chin J Physiol. 2015 Oct 31;58(5):302-11.
    18. Li YD, Chou CT, Liang WZ, Tseng HW, Fang YC, Hung TY, Chang HT, Kuo DH, Kuo CC, Ho CM, Shieh P, Chen FA, Jan CR*. Effect of NPC-14686 (Fmoc-l-Homophenylalanine) on Ca²+ Homeostasis and Viability in OC2 Human Oral Cancer Cells. Chin J Physiol. 2015 Oct 31;58(5):285-93.
    19. Chang HT, Chou CT, Kuo DH, Shieh P, Jan CR, Liang WZ*. The Mechanism of Ca(2+) Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells. J Nat Prod. 2015 Jul 24;78(7):1624-34.
    20. Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR*. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34.
    21. Lu T, Chou CT, Liang WZ, Yu CC, Chang HT, Kuo CC, Chen WC, Kuo DH, Ho CM, Shieh P, Jan CR*. Effect of Antidepressant Doxepin on Ca²+ Homeostasis and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2015 Jun 30;58(3):178-87.
    22. Yeh JH, Sun TK, Chou CT, Chen WC, Lee JK, Yeh HC, Liang WZ, Kuo CC, Shieh P, Kuo DH, Jan CR*. Effect of Sertraline on Ca2+ Fluxes in Rabbit Corneal Epithelial Cells. Chin J Physiol. 2015 Apr 30;58(2):85-94.
    23. Horng CT, Chou CT, Tseng HW, Cheng JS, Chang HT, Chang PM, Chen IL, Hung MC, Tsai YJ, Tsai PC, Liang WZ, Kuo CC, Kuo DH, Ho CM, Lin JR, Shieh P, Jan CR*. Effect of Methoxychlor on Ca2+ Homeostasis and Apoptosis in HA59T Human Hepatoma Cells. Chin J Physiol. 2015 Feb 28;58(1):1-8.
    24. Cheng HH, Chou CT, Sun TK, Liang WZ, Cheng JS, Chang HT, Tseng HW, Kuo CC, Chen FA, Kuo DH, Shieh P, Jan CR. Naproxen-induced Ca2+ movement and death in MDCK canine renal tubular cells. Hum Exp Toxicol. 2015 Nov;34(11):1096-105. doi: 10.1177/0960327115569810. Epub 2015 Jan 30.
    25. Liu FJ, Chou CT, Cheng JS, Chang HT, Liang WZ, Kuo CC, Kuo SY, Kuo DH, Shieh P, Chang FR, Jan CR*. Ca(2+) movement and apoptosis induced by deltamethrin in Madin-Darby canine kidney canine renal tubular cells. Kaohsiung J Med Sci. 2015 Jan;31(1):1-8.
    26. Liang WZ, Chou CT, Hsu SS, Liao WC, Shieh P, Kuo DH, Tseng HW, Kuo CC, Jan CR*. The involvement of mitochondrial apoptotic pathway in eugenol-induced cell death in human glioblastoma cells. Toxicol Lett. 2014 Oct 22;232(1):122-132. doi: 10.1016/j.toxlet.2014.10.023.
    27. Chien JM, Chou CT, Liang WZ, Cheng JS, Chang HT, Tseng HW, Kuo SY, Kuo CC, Chen FA, Shieh P, Ho CM, Lin JR, Kuo DH, Jan CR*. Effect of deoxycholic acid on Ca(2+) movement, cell viability and apoptosis in human gastric cancer cells. Toxicol Mech Methods. 2015 Feb;25(2):113-9.
    28. Yu CC, Chou CT, Sun TK, Liang WZ, Cheng JS, Chang HT, Wang JL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Shieh P, Jan CR*. Effect of melamine on [Ca(2+)]i and viability in PC3 human prostate cancer cells. Environ Toxicol Pharmacol. 2014 Nov;38(3):800-6.
    29. Lin KL, Chou CT, Cheng JS, Chang HT, Liang WZ, Kuo CC, Chen IL, Tseng LL, Shieh P, Wu RF, Kuo DH, Jan CR*. Effect of Fluoxetine on [Ca²⁺]i and Cell Viability in OC2 Human Oral Cancer Cells. Chin J Physiol. 2014 Oct 31;57(5):256-64.
    30. Liang WZ, Chou CT, Chang HT, Cheng JS, Kuo DH, Ko KC, Chiang NN, Wu RF, Shieh P, Jan CR*. The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells. Chem Biol Interact. 2014 Sep 25;221:13-23. doi: 10.1016/j.cbi.2014.07.012. Epub 2014 Aug 7.
    31. Cheng HH, Chou CT, Lu YC, Lu T, Chi CC, Tseng LL, Liu SI, Cheng JS, Kuo CC, Liang WZ, Jan CR*. Celecoxib-induced increase in cytosolic Ca2+ levels and apoptosis in HA59T human hepatoma cells. Hum Exp Toxicol. 2014 Nov;33(11):1089-98. doi: 10.1177/0960327112472996. Epub 2014 Jun 27.
    32. Chang HJ, Chou CT, Chang HT, Liang WZ, Hung TY, Li YD, Fang YC, Kuo CC, Kuo DH, Shieh P, Jan CR*. Mechanisms of resveratrol-induced changes in cytosolic free calcium ion concentrations and cell viability in OC2 human oral cancer cells. Hum Exp Toxicol. 2015 Mar;34(3):289-99. pii: 0960327114537536.
    33. Cheng JS, Chou CT, Liang WZ, Kuo CC, Shieh P, Kuo DH, Jan CR*. The mechanism of bifonazole-induced [Ca(2+)]i rises and non-Ca(2+)-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2014 Dec;34(6):493-9. doi: 10.3109/10799893.2014.921201. Epub 2014 May 22.
    34. Chien JM, Chou CT, Liang WZ, Kuo DH, Kuo CC, Ho CM, Shieh P, Jan CR*. The Mechanism of NPC-14686-Induced [Ca²⁺]i Rises and Non-Ca²⁺-Triggered Cell Death in MG63 Human Osteosarcoma Cells. Chin J Physiol. 2014 Jun 30;57(3). pii: CJP.2014.BAB178. doi: 10.4077/CJP.2014.BAB178. [Epub ahead of print]
    35. Chang HT, Chou CT, Liang WZ, Lu T, Shieh P, Ho CM, Kuo DH, Jan CR*. Effect of thymol on Ca2+ homeostasis and apoptosis in MDCK renal tubular cells. Chin J Physiol. 2014 Apr 30;57(2):90-8. doi: 10.4077/CJP.2014.BAB192.
    36. Cheng HH, Chou CT, Lu YC, Lu T, Chi CC, Tseng LL, Liu SI, Cheng JS, Kuo CC, Liang WZ, Jan CR*. Celecoxib-induced increase in cytosolic Ca2+ levels and apoptosis in HA59T human hepatoma cells. Human and Experimental Toxicology. In press
    37. Chen WC, Chou CT, Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Liang WZ, Jan CR*. M-3M3FBS induces [Ca2+]i rises and apoptosis in SCM1 human gastric cancer cells. Chin J Physiol. 2014 Feb 28;57(1):31-40.
    38. Tseng LL, Ho CM, Liang WZ, Hsieh YD, Jan CR*. Comparison of efficacies of different bone substitutes adhered to osteoblasts with and without extracellular matrix proteins. J Dental Sci. (2013) 8, 399-404.
    39. Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR*. Effect of BayK 8644 on [Ca2+]i and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2013 Dec 31;56(6):318-25.
    40. Liu CP, Chou CT, Liang WZ, Cheng JS, Chang HT, Kuo DH, Ko KC, Chiang NN, Wu RF, Shieh P, Jan CR*. Pathways of [Ca2+]i rise evoked by angiotensin II in MDCK renal tubular cells. J Recept Signal Transduct Res. 2013 Dec;33(6):380-6. doi: 10.3109/10799893.2013.838788. Epub 2013 Sep 25.
    41. Chang HT, Chou CT, Chen IL, Liang WZ, Kuo DH, Huang JK, Shieh P, Jan CR*. Mechanisms of resveratrol-induced changes in [Ca(2+)]i and cell viability in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2013 Oct;33(5):298-303. doi: 10.3109/10799893.2013.822886. Epub 2013 Jul 30.
    42. Chi CC, Chou CT, Liang WZ, Jan CR*. Effect of the pesticide, deltamethrin, on Ca2+ signaling and apoptosis in OC2 human oral cancer cells. Drug Chem Toxicol. 2014 Jan;37(1):25-31. doi: 10.3109/01480545.2013.806528. Epub 2013 Jul 5.
    43. Chang HT, Chen IL, Chou CT, Liang WZ, Kuo DH, Shieh P, Jan CR*. Effect of caffeic acid on Ca2+ homeostasis and apoptosis in SCM1 human gastric cancer cells. Arch Toxicol (2013) 87:2141–2150
    44. Fang YC, Chou CT, Chi CC, Lin KL, Li YD, Cheng HH, Lu YC, Cheng JS, Kuo CC, Jan CR*.Effect of diindolylmethane on Ca(2+) homeostasis and viability in MDCK renal tubular cells. Hum Exp Toxicol. 2013 Apr;32(4):344-53.
    45. Horng CT, Chiang NN, Chen IL, Liang WZ, Chen IS, Kuo DH, Shieh PC, Jan CR*. Effect of clotrimazole on cytosolic Ca(2+) rise and viability in HA59T human hepatoma cells. J Recept Signal Transduct Res. 2013 Apr;33(2):89-95.
    46. Liu SI, Lin KL, Lu T, Lu YC, Hsu SS, Tsai JY, Liao WC, Huang FD, Chi CC, Liang WZ, Tseng LL, Chiang AJ, Jan CR*. M-3M3FBS-induced Ca² ⁺ movement and apoptosis in HA59T human hepatoma cells. Chin J Physiol. 2013 Feb 28;56(1):26-35.
    47. Chien JM, Chou CT, Lu YC, Lu T, Chi CC, Tseng LL, Liu SI, Cheng JS, Kuo CC, Liang WZ, Jan CR*. Effect of the environmental pollutant bisphenol A dimethacylate (BAD) on Ca(2+) movement and viability in OC2 human oral cancer cells. Environ Toxicol Pharmacol. 2013 Mar;35(2):178-84.
    48. Jan CR, Su JA, Teng CC, Sheu ML, Lin PY, Chi MC, Chang CH, Liao WC, Kuo CC, Chou CT. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Toxicology. 2013 Feb 8;304:1-12
    49. Lin KL, Chiang AJ, Chou CT, Wang JL, Kuo CC, Hsieh YD, Tseng LL, Chi CC, Lu T, Pan CC, Jan CR*. Effect of sertraline on [Ca2+]i and viability of human MG63 osteosarcoma cells. Drug Chem Toxicol. 2013 Apr;39(2):231-40.
    50. Jan CR, Lo HR, Chen CY, Kuo SY. Effect of allyl sulfides from garlic essential oil on intracellular Ca2+ levels in renal tubular cells. J Nat Prod. 2012 Dec 28;75(12):2101-7.
    51. Liu CP, Chou CT, Chi CC, Lin KL, Cheng HH, Lu YC, Cheng JS, Kuo CC, Liang WZ, Huang IF, Jan CR*. Mechanism of [Ca2+]i rise induced by angiotensin 1-7 in MDCK renal tubular cells. J Recept Signal Transduct Res. 2012 Dec;32(6):335-41.
    52. Hu SJ, Horng CT, Chen HI, Chang YT, Cheng CM, Shieh P, Jan CR*. Effect of diethylstilbestrol (DES) on Ca2+ homeostasis and viability in OC2 human oral cancer cells. Adaptive Medicine. 2012;4(4):199-208
    53. Tsai JY, Chou CT, Liu SI, Liang WZ, Kuo CC, Liao WC, Lin KL, Hsu SS, Lu YC, Huang JK, Jan CR*. Effect of diindolylmethane on Ca2+ homeostasis and viability in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2012 Oct;32(5):271-8
    54. Chen IS, Mok KT, Chou CT, Liu SI, Kuo CC, Hsu SS, Chang HT, Tsai JY, Liao WC, Jan CR*. Effect of of phenethyl isothiocyanate on Ca2+ movement and viability in MDCK canine renal tubular cells. Hum Exp Toxicol. 2012 Dec;31(12):1251-61.
    55. Liang WZ, Jan CR, Lu CH*. Investigation of 2,6-diisopropylphenol (propofol)-evoked Ca2+ movement and cell death in human glioblastoma cells. Toxicol In Vitro. 2012 Sep;26(6):862-71.
    56. Cheng HH, Lu YC, Chou CT, Cheng JS, Mar GY, Chiang AJ, Fang YC, Kuo CC, Chai KL, Jan CR*. Mechanism of methoxychlor-induced Ca2+ fluxes and cell death in MDCK renal tubular cells. Basic Clin Pharmacol Toxicol. 2012 Oct;111(4):224-31.
    57. Chi CC, Chou CT, Kuo CC, Tseng LL, Su HH, Chu ST, Ho CM, Jan CR*. EFFECT OF M-3M3FBS ON Ca2+ HANDLING AND VIABILITY IN OC2 HUMAN ORAL CANCER CELLS. Acta Physiol Hung. 2012 Mar;99(1):74-86.
    58. Wang JL, Lin KL, Chou CT, Kuo CC, Cheng JS, Hsu SS, Chang HT, Tsai JY, Liao WC, Lu YC, Chen IS, Liu SI, Jan CR*. Effect of celecoxib on Ca2+ handling and viability in human prostate cancer cells (PC3). Drug Chem Toxicol. 2012 Oct;35(4):456-62.
    59. Lu YC, Hsu SS, Chou CT, Huang JK, Chang HT, Tsai JY, Liao WC, Wang JL, Lin KL, Chen IS, Liu SI, Kuo CC, Ho CM, Jan CR*. 3,3’-Diindolylmethane alters Ca2+ homeostasis and viability in MG63 human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2012 Apr;110(4):314-321
    60. Hsu SS, Chou CT, Liao WC, Liang WZ, Kuo CC, Chen H, Chen YT, Liu SY, Jan CR*. Deltamethrin-induced [Ca2+]i Rise and Death in HGB Human Glioblastoma Cells. Chin J Physiol 2012; 55(4):294-304.
    61. Fang YC, Chou CT, Pan CC, Hsieh YD, Liang WZ, Chao D, Tsai JY, Liao WC, Kuo DH, Shieh P, Kuo CC, Jan CR, Shaw CF*. Paroxetine-induced Ca2+ movement and death in OC2 human oral cancer cells. Chin J Physiol. 2011 Oct 31;54(5):310-7.
    62. Chang HT, Hsu SS, Chou CT, Cheng JS, Wang JL, Lin KL, Fang YC, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Huang JK, Kuo CC, Chai KL, Jan CR*. Effect of thymol on Ca2+ homeostasis and viability in MG63 human osteosarcoma cells. Pharmacology 2011;88:201-212.
    63. Hsu SS, Lin KL, Chou CT, Chiang AJ, Liang WZ, Chang HT, Tsai JY, Liao WC, Huang FD, Huang JK, Chen IS, Liu SI, Kuo CC, Jan CR*. Effect of thymol on Ca2+ homeostasis and viability in human glioblastoma cells. Eur J Pharmacol. 2011 Nov 16;670(1):85-91. 
    64. Jan CR, Chen CY, Wang SC, Kuo SY. Phenethyl isothiocyanate induces Ca2+ movement and cytotoxicity in PC3 prostate cancer cells. J Taiwan Inst Chem Eng. 2011;42:895-901.
    65. Cheng JS, Shu SS, Kuo CC, Chou CT, Tsai WL, Fang YC, Kuo LN, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Chai KL, Jan CR*. Effect of diindolylmethane on Ca2+ movement and viability in HA59T human hepatoma cells. Arch Toxicol. 2011 Oct;85(10):1257-66.
    66. Huang JK, Chou CT, Chang HT, Shu SS, Kuo CC, Tsai JY, Liao WC, Wang JL, Lin KL, Lu YC, Chen IS, Liu SI, Ho CM, Jan CR*. Effect of thapsigargin on Ca2+ fluxes and viability in human prostate cancer cells. J Recept Signal Transduct Res. 2011 Jun;31(3):247-55.
    67. Kuo CC, Huang JK, Chou CT, Cheng JS, Tsai JY, Fang YC, Hsu SS, Liao WC, Chang HT, Ho CM, Jan CR*. Effect of bisphenol A on Ca2+ fluxes and viability in Madin-Darby canine renal tubular cells. Drug Chem Toxicol. 2011 Oct;34(4):454-61.
    68. Hsieh YD, Chi CC, Chou CT, Cheng JS, Kuo CC, Liang WZ, Lin KL, Tseng LL, Chu ST, Jan CR*. Carvedilol-induced [Ca2+]i Rise and Apoptosis in Human Oral Cancer Cells. Journal of Receptors and Signal Transduction, 2011; 31(3): 220-228.
    69. Tsai NW*, Lin TK, Chang WN, Jan CR, Huang CR, Chen SD, Cheng KY, Chiang YF, Wang HC, Yang TM, Lin YJ, Lin WC, Chang HW, Lee LH, Lu CH. Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke. Crit Care. 2011 Jul 8;15(4):R163.
    70. Huang JK, Chou CT, Chang HT, Shu SS, Kuo CC, Tsai JY, Liao WC, Wang JL, Lin KL, Lu YC, Chen IS, Liu SI, Ho CM, Jan CR*. The Mechanism of Sertraline-induced [Ca2+]i Rise in Human PC3 Prostate Cancer Cells. Basic Clin Pharmacol Toxicol. 2011 Aug;109(2):103-110
    71. Chien JM, Chou CT, Pan CC, Kuo CC, Tsai JY, Liao WC, Kuo DH, Shieh P, Ho CM, Chu ST, Su HH, Chi CC, Jan CR*. The mechanism of sertraline-induced [Ca2+]i rise in human OC2 oral cancer cells. Hum Exp Toxicol. 2011 Oct;30(10):1635-43.
    72. Chen WC, Hsu SS, Chou CT, Kuo CC, Huang JK, Fang YC, Chang HT, Tsai JY, Liao WC, Wang BW, Shieh P, Kuo DH, Jan CR*. Effect of diallyl disulfide on Ca2+ movement and viability in PC3 human prostate cancer cells. Toxicol in Vitro. 2011 Apr;25(3):636-43.
    73. Tseng LL, Shu SS, Kuo CC, Chou CT, Hsieh YD, Chu ST, Chi CC, Liang WZ, Ho CM, Jan CR*. Effect of Methoxychlor on Ca2+ Handling and Viability in OC2 Human Oral Cancer Cells. Basic Clin Pharmacol Toxicol. 2011;108:341-348.
    74. Tsai JY, Kuo CC, Chou CT, Chao D, Cheng HH, Wang JL, Cheng JS, Lin KL, Huang JK, Chang HT, Jan CR*. Effect of Capsazepine on [Ca2+]i in MDCK Renal Tubular Cells. Drug Development Research. 2011. 72:323-329.
    75. Tsai NW*, Lin TK, Chen SD, Chang WN, Wang HC, Yang TM, Lin YJ, Jan CR, Huang CR, Liou CW, Lu CH. The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke. Clin Chim Acta. 2011 Feb 20;412(5-6):476-9.
    76. Tsai NW*, Chang WN, Shaw CF, Jan CR, Lu CH. Leukocyte apoptosis in patients with acute ischemic stroke. Clin Exp Pharmacol Physiol. 2010 Sep;37(9):884-8. 
    77. Shieh P*, Lee CH, Yi NL, Jan CR. Carvedilol-induced elevation in cytosolic free Ca2+ level and apoptosis in SIRC corneal epithelial cells. Hum Exp Toxicol. 2010 Jun;29(6):477-87.
    78. Tsai NW*, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD, Chuang YC, Lee LH, Lu CH. Serial change in platelet activation markers with aspirin and clopidogrel after acute ischemic stroke. Clin Neuropharmacol. 2010 Jan-Feb;33(1):40-5.
    79. Kuo DH*, Liu LM, Chen HW, Chen FA, Jan CR. Econazole-induced Ca2+ Fluxes and Apoptosis in Human Oral Cancer Cells. Drug Dev Res. 2010. 71:240-248.
    80. Liao WC, Huang CC, Lu YC, Chi CC, Chu ST, Su HT, Kuo CC, Cheng JS, Tseng LL, Ho CM, Jan CR*. Maprotiline-induced Ca2+ Fluxes and Apoptosis in Human Osteosarcoma Cells. Drug Dev Res 2010. 71:268-274.
    81. Liao WC, Chou CT, Kuo CC, Pan CC, Kuo DH*, Shieh P, Cheng JS, Jan CR, Shaw CF. Effect of Thimerosal on Ca2+ Movement and Apoptosis in PC3 Prostate Cancer Cells. Drug Dev Res. 2010. 72:330-336.
    82. Pan CC, Shaw CF, Huang JK, Kuo CC, Kuo DH, Shieh P, Lu T, Chen WC, Ho CM, Jan CR*. Effect of nortriptyline on cytosolic Ca2+ regulation and viability in PC3 human prostate cancer cells. Drug Dev Res  2010. 71:323-330.
    83. Kuo CC, Kuo DH, Huang CJ, Fang YC, Shieh P, Chen FA, Shaw CF, Jan CR*. Nonylphenol-Induced Apoptotic Pathways in SCM1
      Human Gastric Cancer Cells. Drug Dev Res 2010. 71:139-48.
    84. Chang KH, Tan HP, Kuo CC, Kuo DH, Shieh P, Chen FA, Jan CR*. Effect of Nortriptyline on Ca2+ Handling in SIRC Rabbit Corneal Epithelial Cells. Chin J Physiol 2010;53(3):178-84.
    85. Tsai JY, Shieh P, Kuo DH, Chen FA, Kuo CC, Jan CR*. Effect of m-3M3FBS on Ca2+ Movement in PC3 Human Prostate Cancer Cells. Chin J Physiol 2010;53(3):151-9.
    86. Shieh P*, Tsai ML, Chiu MH, Chen YO, Yi NL, Jan CR. Independent effects of the broccoli-derived compound sulforaphane on Ca2+ influx and apoptosis in Madin-Darby canine renal tubular cells. Chin J Physiol. 2010 Aug 31;53(4):215-22.
    87. Fang YC, Kuo DH, Shieh P, Chen FA, Kuo CC, Jan CR*. Effect of m-3M3FBS on Ca2+ movement in Madin-Darby canine renal tubular cells. Hum Exp Toxicol. 2009 Oct;28(10):655-63.
    88. Kuo L, Huang C, Fang Y, Huang C, Wang J, Lin K, Chu S, Chang H, Chien J, Su H,Chi C, Chen W, Tsai J, Liao W, Tseng L, Jan C*. Effect of thimerosal on Ca2+ movement and viability in human oral cancer cells. Hum Exp Toxicol. 2009 May;28(5):301-8. Epub 2009 Aug 6.
    89. Huang CJ, Kuo DH, Chang KH, Shieh P, Chen FA, Fang YC, Kuo CC, Jan CR*. Effect of the Antidepressant Sertraline on Ca(2+) Fluxes in Madin-Darby Canine Renal Tubular Cells. J Recept Signal Transduct Res. 2009 Dec;29(6):342-8.
    90. Lin KL, Huang CC, Cheng JS, Tsai JY, Lu YC, Chang HT, Jan CR*. Ketoconazole-induced JNK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology in Vitro 23 (2009) 1268-1276.
    91. Yeh JH, Huang CC, Yeh MY, Wang JS, Lee JK, Jan CR*. Cadmium-induced cytosolic Ca2+ elevation and subsequent apoptosis in renal tubular cells. Basic Clin Pharmacol Toxicol. 2009 May;104(5):345-51.
    92. Huang C, Huang C, Cheng J, Liu S, Chen I, Tsai J, Chou C, Tseng P, Jan C*. Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells. Hum Exp Toxicol. 2009 Jan;28(1):41-8.
    93. Huang JK, Huang CC, Lu T, Chang HT, Lin KL, Tsai JY, Liao WC, Chien JM, Jan CR*. Effect of MK-886 on Ca Level and Viability in PC3 Human Prostate Cancer Cells. Basic Clin Pharmacol Toxicol. 2009 Jun;104(6):441-7. Epub 2009 Apr 3.
    94. Tsai NW*, Chang WN, Shaw CF, Jan CR, Huang CR, Chen SD, Chuang YC, Lee LH, Lu CH. The value of leukocyte adhesion molecules in patients after ischemic stroke. J Neurol. 2009 Aug;256(8):1296-302
    95. Tsai NW*, Chang WN, Shaw CF, Jan CR, Chang HW, Huang CR, Chen SD, Chuang YC, Lee LH, Wang HC, Lee TH, Lu CH. Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke. Thromb Res. 2009 Jun;124(2):213-8.
    96. Huang CC, Cheng HH, Wang JL, Cheng JS, Chai KL, Fang YC, Kuo CC, Chu ST, Ho CM, Lin KL, Tsai JY, Jan CR*. Effects of Antrodia camphorata extracts on the viability, apoptosis, [Ca2+]i, and MAPKs phosphorylation of OC2 human oral cancer cells. Chin J Physiol. 2009 Jun 30;52(3):128-35.
    97. Tsai JY, Huang CC, Cheng HH, Lin KL, Liao WC, Jan CR*. Nonylphenol-Induced Cytosolic Ca2+ Elevation and Deathin Renal Tubular Cells. Drug Dev Res 2009;70:370-377.
    98. Tsai NW, Lu CH, Chang WN, Shaw CF, Huang CR, Chen SD, Chuang YC, Lee LH, Jan CR*. Dysregulation of Ca2+ movement in platelets from patients with acute ischaemic stroke. Clin Exp Pharmacol Physiol. 2009 Apr;36(4):380-5.
    99. Huang CC, Cheng HH, Lin KL, Cheng JS, Tsai JY, Liao WC, Fang YC, Jan CR*. Tamoxifen-induced [Ca2+]i rise and apoptosis in corneal epithelial cells. Toxicology. 2009 Jan 8;255(1-2):58-64.
    100. Liao WC, Huang CC, Cheng HH, Wang JL, Lin KL, Cheng JS, Chai KL, Hsu PT, Tsai JY, Fang YC, Lu YC, Chang HT, Huang JK, Chou CT, Jan CR*. Effect of calmidazolium on [Ca2+]i and viability in human hepatoma cells. Arch Toxicol. 2009 Jan;83(1):61-8.
    101. Lu T, Huang CC, Lu YC, Lin KL, Liu SI, Wang BW, Chang PM, Chen IS, Chen SS, Tsai JY, Chou CT, Jan CR*. Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. Clin Exp Pharmacol Physiol. 2009 Mar;36(3):297-303.
    102. Chen WC, Huang CC, Huang CJ, Chien JM, Lin KL, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Chou CT, Jan CR*. Mechanism of paroxetine-induced cell death in renal tubular cells. Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):407-13.
    103. Chi CC, Huang CC, Chien JM, Chu ST, Chen WC, Chang HT, Lin KL, Tsai JY, Liao WC, Chou CT, Jan CR*. L-type Ca2+ channel opener BayK 8644-induced Ca2+ influx and Ca2+ release in human oral cancer cells (OC2). Drug Dev Res 2008;58:508-513
    104. Chien JM, Huang CC, Cheng HH, Lin KL, Chen WC, Tseng PL, Chou CT, Tsai JY, Liao WC, Wang BW, Chang PM, Jan CR*. Econazole-evoked [Ca2+]i rise and non-Ca2+-triggered cell death in rabbit corneal epithelial cells (SIRC). J Recept Signal Transduct Res. 2008;28(6):567-79.
    105. Liu SI, Cheng HH, Huang CJ, Chang HC, Chen WC, Chen IS, Hsu SS, Chang HT, Huang JK, Chen JS, Lu YC, Jan CR*. Melittin-induced [Ca2+]i increases and subsequent death in canine renal tubular cells. Hum Exp Toxicol. 2008 May; 27(5):417-24.
    106. Ho CM, Huang CC, Huang CJ, Cheng JS, Chen IS, Tsai JY, Jiann BP, Tseng PL, Kuo SJ, Jan CR*. Effects of antrodia camphorata on viability, apoptosis, and [Ca2+]i in PC3 human prostate cancer cells. Chin J Physiol. 2008 Apr 30;51(2):78-84.
    107. Chang HC, Huang CC, Huang CJ, Cheng JS, Liu SI, Tsai JY, Chang HT, Huang JK, Chou CT, Jan CR*. Desipramine-induced apoptosis in human PC3 prostate cancer cells: Activation of JNK kinase and caspase-3 pathways and a protective role of [Ca2+]i elevation. Toxicology. 2008 Aug 19;250(1):9-14.
    108. Chang HT, Huang CC, Cheng HH, Lu T, Wang JL, Lin KL, Hsu PT, Tsai JY, Liao WC, Lu YC, Huang JK, Jan CR*. Effects of MK-886, a Leukotriene Synthesis Inhibitor, on [Ca2+]i and Apoptosis in MG63 Human Osteosarcoma Cells. Drug Dev Res 2008;69:49-57
    109. Roan CJ, Huang CC, Cheng HH, Chien JM, Chou CT, Lin KL, Liu SI, Lu YC, Chang HT, Huang JK, Jan CR*. Diethylstilbestrol-Induced Estrogen Receptor-Dependent [Ca2+]i Rises and Apoptosis in Chinese Hamster Ovary (CHO) Cells.J Recept Signal Transduct Res. 2008;28(3):307-22.
    110. Chang HT, Huang CC, Cheng HH, Wang JL, Lin KL, Hsu PT, Tsai JY, Liao WC, Lu YC, Huang JK, Jan CR*. Mechanisms of AM404-induced [Ca2+]i rise and death in human osteosarcoma cells. Toxicol Lett. 2008 Jun 10;179(1):53-8.
    111. Chu ST, Huang CC, Huang CJ, Cheng JS, Chai KL, Cheng HH, Fang YC, Chi CC, Su HH, Chou CT, Jan CR*. Tamoxifen-induced [Ca2+]i rises and Ca2+-independent cell death in human oral cancer cells. J Recept Signal Transduct Res. 2007;27(5-6):353-67.
    112. Cheng JS, Huang CC, Chou CT, Jan CR*. Mechanisms of carvedilol-induced [Ca2+]i rises and death in human hepatoma cells.Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov;376(3):185-94.
    113. Lu YC, Cheng HH, Huang CJ, Chu ST, Chi CC, Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Huang JK, Ho CM, Kuo SJ, Jan CR*. Effects of Antrodia Camphorata on Viability, Apoptosis, [Ca2+]i, and MAPKs Phosphorylation in MG63 Human Osteosarcoma Cells. Drug Dev Res 2007; 68:71-8.
    114. Lin MC, Huang CJ, Cheng HH, Chou CT, Wang JL, Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan CR*. Ketoconazole-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in rabbit corneal epithelial cell line (SIRC). J Recept Signal Transduct Res 2007;27(4):295-307.
    115. Liu SI, Huang CC, Huang CJ, Wang BW, Chang PM, Fang YC, Chen WC, Wang JL, Lu YC, Chu ST, Chou CT, Jan CR*. Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation. Toxicol Sci. 2007 Nov;100(1):109-17.
    116. Chen WC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The carcinogen safrole increases intracellular free Ca2+ levels and causes death in MDCK cells. Chin J Physiol. 2007 Feb 28;50(1):34-40.
    117. Wang JL, Chan RC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Ho CM, Jan CR*. Short waves-induced enhancement of proliferation of human chondrocytes: involvement of extracellular signal-regulated MAP-Kinase (ERK). Clin Exp Pharmacol Physiol. 2007 Jul;34(7):581-5.
    118. Huang CJ, Cheng HH, Chou CT, Kuo CC, Lu YC, Tseng LL, Chiang AJ, Liu SI, Chen IS, Jan CR*. Desipramine-induced Ca2+ movement and cytotoxicity in PC3 human prostate cancer cells. Toxicol in Vitro. 2007 Apr;21(3):449-456.
    119. Hsu SS, Huang CJ, Cheng HH, Chou CT, Lee HY, Wang JL, Chen IS, Liu SI, Lu YC, Chang HT, Huang JK, Chen JS, Jan CR*. Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology. 2007 Feb 28;231(1):21-9.
    120. Chou CT, He S, Jan CR*. Paroxetine-induced apoptosis in human osteosacroma cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation. Toxicol Appl Pharmacol. 2007 Feb 1;218(3):265-73.
    121. Chu ST, Cheng HH, Huang CJ, Chang HC, Chi CC, Su HH, Hsu SS, Wang JL, Chen IS, Liu SI, Lu YC, Huang JK, Ho CM, Jan CR*. Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells. Life Sci. 2007 Jan 2;80(4):364-369.
    122. Pan CC, Cheng HH, Huang CJ, Lu YC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Jan CR*. The antidepressant mirtazapine-induced cytosolic Ca2+ elevation and cytotoxicity in human osteosarcoma cells. Chin J Physiol. 2006 Dec 31;49(6):290-7.
    123. Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Wang JK, Lu YC, Jan CR*. Effect of nortriptyline on intracellular Ca2+ handling and proliferation in canine renal tubular cells. Chin J Physiol. 2006 Dec 31;49(6):283-9
    124. Chen WC, Liu SI, Hsu SS, Chang HT, Huang JK, Jan CR*. Effect of riluzole on Ca2+ movement and cytotoxicity in Madin-Darby canine kidney cells. Hum Exp Toxicol. 2006 Aug;25(8):461-9.
    125. Chang HC, Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Wang JK, Lu YC, Chou CT, Jan CR*. Safrole-induced Ca2+ mobilization and cytotoxicity in human PC3 prostate cancer cells. J Recept Signal Transduct Res. 2006;26(3):199-212.
    126. Yeh JH, Cheng HH, Huang CJ, Chung HM, Chiu HF, Yang YL, Yeh MY, Chen WC, Kao CH, Chou CT, Jan CR*. Effect of anandamide on cytosolic Ca2+ levels and proliferation in canine renal tubular cells. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):416-22.
    127. Lin HC, Cheng HH, Huang CJ, Chen WC, Chen IS, Liu SI, Hsu SS, Chang HT, Huang JK, Chen JS, Lu YC, Jan CR*. Safrole-induced cellular Ca2+ increases and death in human osteosarcoma cells. Pharmacol Res. 2006 Aug;54(2):103-10.
    128. Tseng LL, Cheng HH, Huang CJ, Liu SI, Kuo CC, Chen WC, Huang JK, Hsu SS, Chang HT, Kao CH, Ho CM, Jan CR*. Dual effect of flurbiprofen on cell proliferation and agonist-induced Ca2+ movement in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):160-7.
    129. Wang JL, Lin KL, Chen WC, Chou CT, Huang CJ, Liu CS, Hsieh CH, Chang CH, Huang JK, Chang HT, Liu SI, Hsu SS, Jan CR*. Effect of celecoxib on Ca2+ fluxes and proliferation in MDCK renal tubular cells. J Recept Signal Transduct Res. 2005;25(4-6):237-49.
    130. Huang JK, Cheng HH, Huang CJ, Kuo CC, Chen WC, Liu SI, Hsu SS, Chang HT, Lu YC, Tseng LL, Chiang AJ, Chou CT, Jan CR*. Effect of capsazepine on cytosolic Ca2+ levels and proliferation of human prostate cancer cells. Toxicol In Vitro. 2006 Aug;20(5):567-74.
    131. Huang JK, Liu CS, Chen WC, Liu SI, Hsu SS, Chang HT, Chou CT, Hsieh CH, Chang CH, Jan CR*. NPC-14686 (Fmoc-l-homophenylalanine)-induced increases and death in human prostate cancer cells. Life Sci. 2006 Jan 25;78(9):964-9.
    132. Chang HT, Liu CS, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Huang JK, Jan CR*. Econazole induces increases in free intracellular Ca2+ concentrations in human osteosarcoma cells. Hum Exp Toxicol. 2005 Sep;24(9):453-8.
    133. Huang JK, Liu CS, Chou CT, Liu SI, Hsu SS, Chang HT, Hsieh CH, Chang CH, Chen WC, Jan CR*. Effects of econazole on Ca2+ levels and the growth of human prostate cancer PC3 cells. Clin Exp Pharmacol Physiol. 2005 Sep;32(9):735-41.
    134. Huang JK, Huang CJ, Chen WC, Liu SI, Hsu SS, Chang HT, Tseng LL, Chou CT, Chang CH, Jan CR*. Independent [Ca2+]i increases and cell proliferation induced by the carcinogen safrole in human oral cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jul;372(1):88-94.
    135. Wang JL, Liu CS, Lin KL, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chang HT, Jan CR*. Nonylphenol-induced Ca2+ elevation and Ca2+-independent cell death in human osteosarcoma cells. Toxicol Lett. 2005 Dec 30;160(1):76-83.
    136. Chang HT, Liu CS, Chou CT, Hsieh CH, Chang CH, Chen WC, Liu SI, Hsu SS, Chen JS, Jiann BP, Lu YC, Jan CR*. Thimerosal-induced cytosolic Ca2+ elevation and subsequent cell death in human osteosarcoma cells. Pharmacol Res. 2005; 52(4): 328-33.
    137. Jan CR*. Effect of p-chloroamphetamine on calcium movement and viability in renal tubular cells. Life Sci. 2005 Jun 17;77(5):589-99.
    138. Yeh JH, Huang CJ, Lee JW, Hsu SS, Chen JS, Cheng HH, Chang HT, Huang JK, Chung HM, Yeh MY, Jan CR*. 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells. Life Sci. 2005, 77:336-344.
    139. Chang HT, Chen WC, Chen JS, Lu YC, Hsu SS, Wang JL, Cheng HH, Cheng JS, Jiann BP, Chiang AJ, Huang JK, Jan CR*. Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells. Life Sci. 2005;76:2091-101.
    140. Jan CR*, Chen CH, Wang SC, Kuo SY. Effect of methylglyoxal on intracellular calcium levels and viability in renal tubular cells. Cell Signal. 2005 Jul;17(7):847-55.
    141. Ho CM, Kuo SY, Chen CH, Huang JK, Jan CR*. Effect of desipramine on [Ca2+]i levels and growth in renal tubular cells. Cell Signal. 2005 Jul;17(7):837-45.
    142. Jan CR*, Chao YY. Novel effect of Y-24180, a presumed specific platelet-activating factor receptor antagonist, on Ca2+ levels and growth of human osteosarcoma cells. Pharmacol Res. 2005 Mar;51(3):189-95.
    143. Cheng HH, Ho CM, Huang CJ, Hsu SS, Jiann BP, Chen JS, Huang JK, Chang HT, Lo YK, Yeh JH, Jan CR*. Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. Pharmacology. 2005;73(4):169-74.
    144. Tseng LL, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR*.  Effect of calmidazolium on Ca2+ movement and proliferation in human osteosarcoma cells. Clin Exp Pharmacol Physiol. 2004 Oct;31(10):732-7.
    145. Hsu SS, Huang CJ, Chen JS, Cheng HH, Chang HT, Jiann BP, Lin KL, Wang JL, Ho CM, Jan CR*. Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004 Sep;95(3):124-30.
    146. Liu CP, Jan CR*. Effect of carvedilol on Ca2+ movement and cytotoxicity in human MG63 osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004 Aug;95(2):59-65.
    147. Teng HP, Huang CJ, Yeh JH, Hsu SS, Lo YK, Cheng JS, Cheng HH, Chen JS, Jiann BP, Chang HT, Huang JK, Jan CR*. Capsazepine elevates intracellular Ca2+ in human osteosarcoma cells, questioning its selectivity as a vanilloid receptor antagonist. Life Sci. 2004 Oct 8;75(21):2515-26.
    148. Chou KJ, Jan CR*, Lee PT, Chen CL, Chung HM, Hwang YY, Chou JD, Fang HC. Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. Thromb Haemost. 2004 Sep;92(3):621-6.
    149. Huang JK, Chen WC, Huang CJ, Hsu SS, Chen JS, Cheng HH, Chang HT, Jiann BP, Jan CR*.        Nordihydroguaiaretic acid-induced Ca2+ handling and cytotoxicity in human prostate cancer cells. Life Sci. 2004 Sep 24;75(19):2341-51.
    150. Hsu SS, Chen WC, Lo YK, Cheng JS, Yeh JH, Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*. Effect of the antidepressant maprotiline on Ca2+ movement and proliferation in human prostate cancer cells. Clin Exp Pharmacol Physiol. 2004 Jul;31(7):444-9.
    151. Hsu SS, Chen WC, Lo YK, Cheng JS, Liu CP, Cheng HH, Chen JS, Chang HT, Jiann BP, Huang JK, Jan CR*. Effect of maprotiline on Ca2+ movement in human neuroblastoma cells. Life Sci. 2004 Jul 16;75(9):1105-12
    152. Jan CR*, Chao YY. Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells. Cell Signal. 2004 Aug;16(8):959-65.
    153. Hsu SS, Chen WC, Jiann BP, Chen JS, Huang JK, Chang HT, Cheng HH, Lo YK, Ho CM, Jan CR*. Effect of the antidepressant maprotiline on calcium movement and the viability of renal tubular cells. Arch Toxicol. 2004 Aug;78(8):453-9. Epub 2004 Apr 1
    154. Wang JL, Lin KL, Chen JS, Lu YC, Jiann BP, Chang HT, Hsu SS, Chen WC, Huang JK, Ho CM, Jan CR*. Effect of celecoxib on Ca2+ movement and cell proliferation in human osteoblasts. Biochem Pharmacol. 2004 Mar 15;67(6):1123-30.
    155. Yeh JH, Chung HM, Ho CM, Jan CR*. Mercury-induced Ca2+ increase and cytotoxicity in renal tubular cells. Life Sci. 2004 Mar 5;74(16):2075-83.
    156. Chao YY, Jan CR*. Effect of Y-24180 on Ca2+ movement and proliferation in renal tubular cells. Life Sci 2004 Jan 2;74(7):923-33.
    157. Cheng JS, Lo YK, Yeh JH, Cheng HH, Liu CP, Chen WC, Jan CR*. Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. Chin J Physiol. 2003 Sep 30;46(3):117-22.
    158. Chang HT, Hsu SS, Chen JS, Lin KL, Wang JL, Cheng HH, Lu YC, Jiann BP, Liu CP, Huang JK, Yeh JH, Chiang AJ, Chen WC, Jan CR*. Effect of diethylstilbestrol on Ca2+ handling and cell viability in human breast cancer cells. Chin J Physiol. 2003 Dec 31;46(4):187-92.
    159. Jan CR*, Lu YC, Tseng LL, Jiann BP, Chang HT, Wang JL, Chen WC, Huang JK. Effect of the antidepressant desipramine on cytosolic Ca2+ movement and proliferation in human osteosarcoma cells. Pharmacology. 2003 Dec;69(4):190-6.
    160. Jan CR*, Jiann BP, Lu YC, Chang HT, Yu CC, Chen WC, Huang JK. Oxidation by thimerosal increases calcium levels in renal tubular cells. Pharmacol Toxicol. 2003 Sep;93(3):123-7.
    161. Kuo SU, Ho CM, Chen WC, Jan CR*. Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells. Arch Toxicol. 2003 Nov;77(11):630-7. Epub 2003 Aug 20.
    162. Jan CR*, Lu YC, Jiann BP, Chang HT, Wang JL, Chen WC, Huang JK. Novel effect of n-palmitoyl-l-serine phosphoric acid on cytosolic Ca2+ levels in human osteoblasts. Pharmacol Toxicol. 2003; Aug;93(2):71-6.
    163. Jan CR*, Kuo SY, Cheng JS, Lo YK, Liu CP, Chen WC. Effect of NPC-14686 (Fmoc-L-homophenylalanine) on intracellular Ca2+ levels in human hepatoma cells. Life Sci. 2003 Apr 25;72(23):2571-80.
    164. Jan CR*, Chiang AJ, Chang HT, Roan CJ, Lu YC, Jiann BP, Ho CM, Huang JK. The anti-breast cancer drug tamoxifen alters Ca2+ movement in Chinese hamster ovary (CHO-K1) cells. Arch Toxicol. 2003 Mar;77(3):160-6.
    165. Kuo SY, Jiann BP, Lu YC, Chang HT, Chen WC, Huang JK, Jan CR*. Thiol oxidation by 2,2'-dithiodipyridine induced calcium mobilization in MG63 human osteosarcoma cells. Life Sci. 2003 Feb 28;72(15):1733-43.
    166. Jan CR*, Jiann BP, Chang HT, Yu CC, Lu YC, Yeh JH, Chen WC, Law YP, Huang JK. Effect of NPC-15199 on Ca2+ levels in renal tubular cells. Chin J Physiol. 2002 Sep 30;45(3):117-22. Erratum in: Chin J Physiol. 2003 Dec 31;45(4):200.
    167. Lu CH, Su W, Lo YK, Chen WC, Chang WN, Wang JL, Tsai YC, Lee PY, Jan CR*. Effect of t-butyl hydroperoxide on Ca2+ movement in PC12 pheochromocytoma cells. Chin J Physiol. Jun 2002 Jun 30;45(2):51-6.
    168. Lu YC, Su W, Jiann BP, Chang HT, Huang JK, Jan CR*.    Effect of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP55,940) on intracellular Ca2+ levels in human osteosarcoma cells. Chin J Physiol. 2002 Sep 30;45(3):95-100. Erratum in: Chin J Physiol. 2002 Dec 31;45(4):200.
    169. Liu CP, Chiang HT, Jan CR*. Novel effect of carvedilol on Ca2+ movement in renal tubular cells. Biochem Pharmacol. 2002 Dec 15;64 (12):1777-84.
    170. Jan CR*, Lu YC, Jiann BP, Chang HT, Su W, Chen WC, Huang JK. Novel effect of CP55,940, a CB1/CB2 cannabinoid receptor agonist, on intracellular free Ca2+ levels in bladder cancer cells. Chin J Physiol. 2002 Mar 31;45(1):33-9. Erratum in: Chin J Physiol. 2002 Dec 31;45(4):200.
    171. Jiann BP, Chou KJ, Chang HT, Chen WC, Huang JK, Jan CR*. Effect of triethyltin on Ca2+ movement in Madin-Darby canine kidney cells. Human Experi Toxicol. 2002;21:457-62.
    172. Jan CR*, Jiann BP, Lu YC, Chang HT, Huang JK. Effect of olvanil (N-vanillyl-cis-9-octadecenoamide) on cytosolic Ca2+ increase in renal tubular cells. Life Sci. 2002 Nov 15;71(26):3081-90.
    173. Jan CR*, Lu YC, Jiann BP, Chang HT, Huang JK. Effect of riluzole on cytosolic Ca2+ handling in human osteosarcoma cells. Pharmacology. 2002 Nov;66(3):120-7.
    174. Cheng JS, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in hepatocytes. Toxicol in Vitro. 2002 Oct;16(5):485-90.
    175. Lu YC, Jiann BP, Chang HT, Huang JK, Chen WC, Su W, Jan CR*. Effect of the anti-breast cancer drug tamoxifen on Ca2+ movement in human osteosarcoma cells. Pharmacol Toxicol. 2002 Jul;91(1):34-9.
    176. Wang GJ, Lin LC, Chen CF, Cheng JS, Lo YK, Chou KJ, Lee KC, Liu CP, Wu YY, Su W, Chen WC, Jan CR*. Effect of timosaponin A-III, from Anemarrhenae asphodeloides Bunge (Liliaceae), on calcium mobilization in vascular endothelial and smooth muscle cells and on vascular tension. Life Sci. 2002 Jul 19;71(9):1081-90.
    177. Lin MC, Jan CR*. The anti-anginal drug fendiline elevates cytosolic Ca2+ in rabbit corneal epithelial cells. Life Sci. 2002 Jul 19;71(9):1071-9.
    178. Cheng JS, Liu CP, Lo YK, Chou KJ, Su W, Law YP, Chou KJ, Wang JL, Chen WC, Jan CR*. Gossypol, a component in cottonseed, induces increases in cytosolic Ca2+ levels in Chang liver cells. Toxicon. 2002 Jul;40(7):851-6.
    179. Chao YY, Chen IS, Yeh JL, Chen JJ, Ko YC, Cheng JS, Liu CP, Lo YK, Su W, Chou KJ, Chen WC, Jan CR*. Novel action of lignans isolated from Hernandia nymphaeifolia on Ca2+ signaling in renal tubular cells. Eur J Pharmacol. 2002 May 17;443(1-3):31-8.
    180. Jiann BP, Lu YC, Chang HT, Hunag JK, Jan CR*. Effect of clomiphene on Ca2+ movement in human prostate cancer cells. Life Sci. 2002 May 17;70(26):3167-78.
    181. Chao YY, Jan CR, Ko YC, Chen JJ, Jiann BP, Lu YC, Chen WC, Su W, Chen IS. Effect of lignans isolated from Hernandia nymphaeifolia on estrogenic compounds-induced calcium mobilization in human neutrophils. Life Sci. 2002 May 17;70(26):3109-21.
    182. Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK, Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in C6 glioma cells. Neurochem Int. 2002 Mar;40(3):249-54.
    183. Jan CR*, Jiann BP, Lu YC, Chang HT, Su W, Chen WC, Yu CC, Huang JK. Effect of the organotin compound triethyltin on Ca2+ handling in human prostate cancer cells. Life Sci. 2002 Feb 1;70(11):1337-45.
    184. Chen WC, Cheng JS, Chou KJ, Tang KY, Huang JK, Tseng LL, Wang JL, Lee KC, Jan CR*. Effect of 17beta-estradiol on intracellular Ca2+ levels in renal tubular cells. Pharmacology. 2002 Feb;64(2):84-90.
    185. Chang HT, Huang JK, Wang JL, Cheng JS, Lee KC, Lo YK, Liu CP, Chou KJ, Chen WC, Su W, Law YP, Jan CR*. Tamoxifen-induced increases in cytoplasmic free Ca2+ levels in human breast cancer cells. Breast Cancer Res Treat. 2002 Jan;71(2):125-31.
    186. Chao YY, Su W, Jan CR*, Ko YC, Chen JJ, Cheng JS, Liu CP, Lo YK, Chou KJ, Lee KC, Chen WC, Chen IS. Novel action of lignans isolated from Hernandia nymphaeifolia on Ca2+ signaling in human neutrophils. Arch Toxicol. 2002Jan;75(11-12):695-702.
    187. Wang JL, Chang HT, Tseng LL, Liu CP, Lee KC, Chou KJ, Cheng JS, Lo YK, Su W, Law YP, Chen WC, Chan RC, Jan CR*. Nordihydroguaiaretic acid elevates osteoblastic intracellular Ca2+. Pharmacol Toxicol. 2001 Dec;89(6):301-5.
    188. Wang JW, Su W, Law YP, Lu CH, Chen YC, Wang JL, Chang HJ, Chen WC, Jan CR*. Mechanism of bradykinin-induced Ca2+ mobilization in MG63 human osteosarcoma cells. Horm Res. 2001;55(6):265-70.
    189. Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee KC, Lo YK, Chang HT, Huang JK, Jan CR*. Mechanism of bifonazole-induced [Ca2+]i increases in MDCK renal tubular cells. Chin J Physiol. 2001 Sep 30;44(3):97-101.
    190. Chen WC, Huang JK, Cheng JS, Tsai JC, Chiang AJ, Chou KJ, Liu CP, Jan CR. AM-404 elevates renal intracellular Ca2+, questioning its selectivity as a pharmacological tool for investigating the anandamide transporter. J Pharmacol Toxicol Methods. 2001 May-Jun;45(3):195-8.
    191. Su W, Tseng LL, Lin MC, Chang HJ, Lee KC, Chou KJ, Lo YK, Cheng JS, Chang HT, Wang JL, Liu CP, Chen WC, Jan CR*. Effect of nordihydroguaiaretic acid on intracellular Ca2+ concentrations in C6 glioma cells. Neurochem Int. 2002 Mar;40(3):249-54.
    192. Lee KC, Chang HT, Chou KJ, Tang KY, Wang JL, Lo YK, Huang JK, Chen WC, Su W, Law YP, Jan CR*. Mechanism underlying histamine-induced intracellular Ca2+ movement in PC3 human prostate cancer cells. Pharmacol Res. 2001 Dec;44(6):547-52.
    193. Wu SN, Jan CR*, Chiang HT. Fenamates stimulate BKCa channel osteoblast-like MG-63 cells activity in the human. J Investig Med. 2001 Nov;49(6):522-33.
    194. Lo YK, Tang KY, Chang WN, Lu CH, Cheng JS, Lee KC, Chou KJ, Liu CP, Chen WC, Su W, Law YP, Jan CR*. Effect of oleamide on Ca2+ signaling in human bladder cancer cells. Biochem Pharmacol. 2001 Nov 15;62(10):1363-9.
    195. Cheng JS, Chou KJ, Wang JL, Lee KC, Tseng LL, Tang KY, Huang JK, Chang HT, Su W, Law YP, Jan CR*. Fendiline mobilizes intracellular Ca2+ in Chang liver cells. Clin Exp Pharmacol Physiol. 2001 Sep;28(9):729-33.
    196. Tseng CJ, Chan JY, Lo WC, Jan CR*. Modulation of catecholamine release by endogenous adenosine in the rat adrenal medulla. J Biomed Sci. 2001 Sep;8(5):389-94.
    197. Chou KJ, Tseng LL, Cheng JS, Wang JL, Fang HC, Lee K C, Su W, Law YP, Jan CR*. CP55,940 increases intracellular Ca2+ levels in Madin-Darby canine kidney cells. Life Sci. 2001 Aug 17;69(13):1541-8.
    198. Cheng JS, Lee KC, Wang JL, Chang HT, Chou KJ, Tang KY, Jan CR*. haracterization of histamine-induced increases in intracellular free Ca2+ concentrations in Chang liver cells. J Recept Signal Transduct Res. 2001 Feb;21(1):1-9.
    199. Chen YC, Wang JL, Liu CP, Cheng JS, Chang HT, Yuk-Keung L, Su W, Law YP, Chen WC, Jan CR*. Clomiphene, an ovulation-inducing agent, causes [Ca2+]i increases in human osteoblast-like cells. Chin J Physiol. 2001 Jun 30;44(2):67-72.
    200. Cheng JS, Wang JL, Lo YK, Chou KJ, Lee KC, Liu CP, Chang HT, Jan CR*. Effects of the antianginal drug fendiline on Ca2+ movement in hepatoma cells. Hum Exp Toxicol. 2001 Jul;20(7):359-64.
    201. Chen YC, Chen SJ, Chang HT, Huang JK, Wang JL, Tseng LL, Chang HJ, Su W, Law YP, Chen WC, Jan CR*. Mechanisms of diethylstilbestrol-induced calcium movement in MG63 human osteosarcoma cells. Toxicol Lett. 2001 Jul 6;122(3):245-53.
    202. Jan CR*, Lee KC, Chou KJ, Cheng JS, Wang JL, Lo YK, Chang HT, Tang KY, Yu CC, Huang JK. Fendiline, an anti-anginal drug, increases intracellular Ca2+ in PC3 human prostate cancer cells. Cancer Chemother Pharmacol. 2001 Jul;48(1):37-41.
    203. Wang JL, Lee KC, Tang KY, Lu T, Chang CH, Chow CK, Chen WC, Su W, Law YP, Jan CR*. Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells. Arch Toxicol. 2001 Jun;75(4):214-20.
    204. Chen LW, Jan CR*. Mechanisms and modulation of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced Ca2+ mobilization in human neutrophils. Int Immunopharmacol. 2001 Jul;1(7):1341-9.
    205. Chang HT, Huang JK, Wang JL, Cheng JS, Lee KC, Lo YK, Lin MC, Tang KY, Jan CR*. Tamoxifen-Induced Ca2+ Mobilization in Bladder Female Transitional Carcinoma Cells. Arch Toxicol. 2001 May;75(3):184-8.
    206. Lo YK, Cheng JS, Wang JL, Lee KC, Chou KJ, Chang HT, Tang KY, Jan CR*. Fendiline-Induced Ca2+ movement in A10 smooth muscle cells. Chin J Physiol. 2001 Mar 31;44(1):19-24.
    207. Tang KY, Lu T, Chang CH, Lo YK, Cheng JS, Wang JL, Chang HT, Jan CR*. Effect of fluoxetine on intracellular Ca2+ levels in bladder female transitional carcinoma (BFTC) cells. Pharmacol Res. 2001 May;43(5):503-8.
    208. Chen LW, Jan CR*. Effect of the antianginal drug bepridil on intracellular Ca2+ release and extracellular Ca2+ influx in human neutrophils. Int Immunopharmacol. 2001 May;1(5):945-53.
    209. Lee KC, Tseng LL, Chen YC, Wang JW, Lu CH, Cheng JS, Wang JL, Lo YK, Jan CR*. Mechanisms of histamine-induced intracellular Ca2+ release and extracellular Ca2+ entry in MG63 human osteosarcoma cells. Biochem Pharmacol. 2001 Jun 15;61(12):1537-41.
    210. Jan CR*, Yu CC, Huang JK. Dual effect of the antianginal drug fendiline on bladder female transitional carcinoma cells: mobilization of intracellular CA2+ and induction of cell death. Pharmacology. 2001 May;62(4):218-23.
    211. Jan CR*, Yu CC, Huang JK. Clomiphene, an ovulation-inducing agent, mobilizes intracellular Ca2+ and causes extracellular Ca2+ influx in bladder female transitional carcinoma cells. Horm Res. 2000;54(3):143-8.
    212. Huang JK, Jan CR*. Mechanism of estrogens-induced increases in intracellular Ca2+ in PC3 human prostate cancer cells. Prostate. 2001 May 15;47(3):141-8.
    213. Huang JK, Jan CR*. Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. Life Sci. 2001 Jan 19;68(9):997-1004.
    214. Cheng JS, Lee KC, Wang JL, Tseng LL, Chou KJ, Tang KY, Jan CR*. Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells. Chin J Physiol. 2000 Dec 31;43(4):165-9.
    215. Huang JK, Jan CR*. Linoleamide, a brain lipid that induces sleep, increases cytosolic Ca2+ levels in MDCK renal tubular cells. Life Sci. 2001 Jan 19;68(9):997-1004.
    216. Tang KY, Cheng JS, Lee KC, Chou KJ, Huang JK, Chen WC, Jan CR*. Fluoxetine-induced Ca2+ signals in Madin-Darby canine kidney cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;363(1):16-20.
    217. Jan CR*, Cheng JS, Roan CJ, Lee KC, Chen WC, Chou KJ, Tang KY, Wang JL. Effect of diethylstilbestrol (DES) on intracellular Ca2+ levels in renal tubular cells. Steroids. 2001 Jun;66(6):505-10.
    218. Lee KC, Chou KJ, Cheng JS, Wang JL, Tang KY, Tseng LL, Jan CR*. Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells. Pharmacol Toxicol. 2001 Jan;88(1):20-6.
    219. Wang JL, Cheng JS, Chan RC, Tseng LL, Chou KJ, Tang KY, Lee KC, Lo YK, Wang JW, Jan CR*. The anti-anginal drug fendiline increases intracellular Ca2+ levels in MG63 human osteosarcoma cells. Toxicology Letters  119 (3) 227-233.
    220. Chen WC, Lin MC, Chou KJ, Fang HC, Liu CP, Cheng JS, Lo YK, Lee KC, Wang JL, Su W, Law YP, Jan CR*. Novel effects of a sleep-inducing lipid, oleamide, on Ca2+ signaling in renal tubular cells. Drug Dev Res. 2001;54:40-4.
    221. Jan CR*, Yu CC, Huang JK. Clomiphene, an ovulation-inducing agent, mobilizes intracellular Ca2+ and causes extracellular Ca2+ influx in bladder female transitional carcinoma cells. Horm Res. 2000;54(3):143-8.
    222. Cheng JS, Lee KC, Wang JL, Tseng LL, Chou KJ, Tang KY, Jan CR*. Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells. Chin J Physiol. 2000 Dec 31;43(4):165-9.
    223. Jan CR*, Yu CC, Huang JK. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) (W-7) causes increases in intracellular free Ca2+ levels in bladder female transitional carcinoma (BFTC) cells. Anticancer Res. 2000 Nov-Dec;20(6B):4355-9.
    224. Jan CR*, Wang JL, Lin MC, Lee KC, Chou KJ, Chiang HT. Ca2+ mobilization induced by delta-hexachlorocyclohexane in Madin Darby canine kidney cells. Drug Dev Res. 2000;50:186-92.
    225. Huang JK, Jan CR*. Intracellular calcium concentrations in human bladder tumor cells could be increased by NPC-14686, a novel anti-inflammatory agent. Drug Development Research. 50:147-152.
    226. Jan CR*, Chou KJ, Lee KC, Wang JL, Tseng LL, Cheng JS, Chen WC. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74(8):447-51.
    227. Lu CH, Lee KC, Chen YC, Cheng JS, Yu MS, Chen WC, Jan CR*. Lindane (gamma-hexachlorocyclohexane) induces internal Ca2+ release and capacitative Ca2+ entry in Madin-Darby canine kidney cells. Pharmacol Toxicol. 2000 Oct;87(4):149-55.
    228. Chen LW, Jan CR*. Mechanisms underlying ATP-induced Ca2+ mobilization in human neutrophils. Shock. 2000 Nov;14(5):509-13.
    229. Jan CR*, Wang JL, Chou KJ, Cheng JS, Lee KC, Tseng LL, Wang SP, Tang KY, Huang JK. NPC-14686, a novel anti-inflammatory agent, increased intracellular Ca2+ concentrations in MDCK renal tubular cells. Int J Immunopharmacol. 2000 Nov;22(11):915-21.
    230. Chou KJ, Fang HC, Chung HM, Cheng JS, Lee KC, Tseng LL, Tang KY, Jan CR*. Effect of betulinic acid on intracellular free Ca2+ levels in Madin Darby canine kidney cells. Eur J Pharmacol. 2000 Nov 17;408(2):99-106.
    231. Wu SN, Jan CR*, Li HF, Chiang HT. Characterization of inhibition by risperidone of the inwardly rectifying K+ current in pituitary GH(3) cells. Neuropsychopharmacology. 2000 Dec;23(6):676-89.
    232. Jan CR*, Cheng JS, Chou KJ, Wang SP, Lee KC, Tang KY, Tseng LL, Chiang HT. Dual effect of tamoxifen, an anti-breast-cancer drug, on intracellular Ca2+ and  cytotoxicity in intact cells. Toxicol Appl Pharmacol. 2000 Oct 1;168(1):58-63.
    233. Jan CR*, Lu CH, Chen YC, Cheng JS, Tseng LL, Jun-Wen W. Ca2+ mobilization induced by W-7 in MG63 human osteosarcoma cells. Pharmacol Res. 2000 Oct;42(4):323-7.
    234. Wu SN, Hwang T, Teng CM, Li HF, Jan CR. The mechanism of actions of 3-(5'-(hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) on Ca2+-activated K+ currents in GH(3) lactotrophs. Neuropharmacology. 2000 Jul 24;39(10):1788-99.
    235. Jan CR*, Tseng CJ. MK-886, a leukotriene biosynthesis inhibitor, as an activator of Ca(2+) mobilization in Madin-Darby canine kidney (MDCK) cells. J Pharmacol Exp Ther. 2000 Jul;294(1):96-102.
    236. Jan CR*, Yu CC, Huang JK. NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin J Physiol. 2000 Mar 31;43(1):29-33.
    237. Lo WC, Jan CR, Chiang HT, Tseng CJ. Modulatory effects of carbon monoxide on baroreflex activation in nucleus tractus solitarii of rats. Hypertension. 2000 Jun;35(6):1253-7.
    238. Jan CR*, Tseng CJ, Chou KJ, Chiang HT. Novel effects of clotrimazole on Ca2+ signaling in Madin Darby canine kidney cells. Life Sci. 2000;66(23):2289-96.
    239. Jan CR*, Tseng CJ. Mechanisms of nordihydroguaiaretic acid-induced [Ca2+]i increases in MDCK cells. Life Sci. 2000 Mar 24;66(18):1753-62.
    240. Jan CR*, Tseng CJ, Chou KJ, Chiang HT. Novel effects of propranolol. Release of internal Ca(2+) followed by activation of capacitative Ca(2+) entry in Madin Darby canine kidney cells.  Cell Signal. 2000 Apr;12(4):265-9.
    241. Jan CR*, Lin MC, Chou KJ, Huang JK. Novel effects of gossypol, a chemical contraceptive in man: mobilization of internal Ca(2+) and activation of external Ca(2+) entry in intact cells. Biochim Biophys Acta. 2000 Apr 17;1496(2-3):270-6.
    242. Jan CR*, Tseng CJ, Chen WC. Fendiline increases [Ca2+]i in Madin Darby canine kidney (MDCK) cells by releasing internal Ca2+ followed by capacitative Ca2+ entry. Life Sci. 2000;66(11):1053-62.
    243. Jan CR*, Chen LW, Lin MW. Ca(2+) mobilization evoked by chloroform in Madin-Darby canine kidney cells. J Pharmacol Exp Ther. 2000 Mar;292(3):995-1001.
    244. Jan CR*, Tseng CJ. A novel action of the antianginal drug bepredil: induction of internal Ca2+ release and external Ca2+ influx in Madin-Darby canine kidney epithelial cells. Biochem Pharmacol. 2000 Mar 15;59(6):639-46.
    245. Jan CR*, Wang KY, Tseng CJ. Effect of sevoflurane on Ca2+ mobilization in Madin-Darby canine kidney cells. Biochem Pharmacol. 2000 Feb 15;59(4):393-400.
    246. Jan CR*, Tseng CJ. Calmidazolium-induced rises in cytosolic calcium concentrations in Madin Darby canine kidney cells. Toxicol Appl Pharmacol. 2000 Jan 15;162(2):142-50.
    247. Chen WC, Cheng JS, Tsai JCR, Jan CR*. Calcium signals induced by the endoplasmic reticulum Ca2+ pump inhibitior cyclopiazonic acid in renal tubular cells. In Vitro & Mol Toxicol. 2000;13:191-8.
    248. Jan CR*, Tseng CJ. Mechanisms of miconazole-induced rise in cytoplasmic calcium concentrations in Madin Darby canine kidney cells. Life Sci. 1999 Oct 29;65(23):2513-22.
    249. Jan CR*, Tseng CJ. W-7 induces [Ca2+]i increases in Madin-Darby canine kidney cells. J Pharmacol Exp Ther. 2000 Jan;292(1):358-65.
    250. Huang JK, Jan CR*. AA-861-induced Ca(2+) mobilization in Madin Darby canine kidney cells.  Toxicol Appl Pharmacol. 1999 Dec 1;161(2):202-8.
    251. Jan CR*, Wu SN, Tseng CJ. Zn2+ increases resting cytosolic Ca2+ levels and abolishes capacitative Ca2+ entry induced by ATP in MDCK cells. Naunyn Schmiedebergs Arch Pharmacol. 1999 Sep;360(3):249-55.
    252. Jan CR*, Wu SN, Tseng CJ. The ether lipid ET-18-OCH3 increases cytosolic Ca2+ concentrations in Madin Darby canine kidney cells. Br J Pharmacol. 1999 Jul;127(6):1502-10.
    253. Wu SN, Jan CR*, Li HF. Ruthenium red-mediated inhibition of large-conductance Ca2+-activated K+ channels in rat pituitary GH3 cells. J Pharmacol Exp Ther. 1999 Sep;290(3):998-1005.
    254. Jan CR*, Wu SN, Tseng CJ. A further investigation of ATP-induced calcium mobilization in MDCK cells. Chin J Physiol. 1999 Mar 31;42(1):33-9.
    255. Jan CR*, Ho CM, Wu SN, Tseng CJ. Multiple effects of 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF 96365) on Ca2+ signaling in MDCK cells: depletion of thapsigargin-sensitive Ca2+ store followed by capacitative Ca2+ entry, activation of a direct Ca2+ entry, and inhibition of thapsigargin-induced capacitative Ca2+ entry. Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):92-101.
    256. Jan CR*, Ho CM, Wu SN, Tseng CJ. Mechanism of rise and decay of thapsigargin-evoked calcium signals in MDCK cells. Life Sci. 1999;64(4):259-67.
    257. Jan CR*, Ho CM, Wu SN, Tseng CJ. Multiple effects of econazole on calcium signaling: depletion of thapsigargin-sensitive calcium store, activation of extracellular calcium influx, and inhibition of capacitative calcium entry. Biochim Biophys Acta. 1999 Jan 11;1448(3):533-42.
    258. Jan CR*, Ho CM, Wu SN, Tseng CJ. Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Eur J Pharmacol. 1999 Jan 15;365(1):111-7.
    259. Wu SN, Jan CR, Li HF, Chen SA. Stimulation of large-conductance Ca2+-activated K+ channels by Evans blue in cultured endothelial cells of human umbilical veins. Biochem Biophys Res Commun. 1999 Jan 27;254(3):666-74.
    260. Lo WC, Jan CR, Wu SN, Tseng CJ. Cardiovascular effects of nitric oxide and adenosine in the nucleus tractus solitarii of rats. Hypertension. 1998 Dec;32(6):1034-8.
    261. Wu SN, Li HF, Jan CR. Regulation of Ca2+-activated nonselective cationic currents in rat pituitary GH3 cells: involvement in L-type Ca2+ current. Brain Res. 1998 Nov 23;812(1-2):133-41.
    262. Wu SN, Li HF, Jan CR, Chen IJ, Lo YC. Selective block by glyceryl nonivamide of inwardly rectifying K+ current in rat anterior pituitary GH3 cells. Life Sci. 1998;63(19):PL281-8.
    263. Li HF, Shen AY, Jan CR, Wu SN. Co-activation of nonselective cation channels by store depletion and oxidative stress in monocytic U937 cells. Chin J Physiol. 1998 Jun 30;41(2):113-9.
    264. Jan CR*, Chen WC, Wu SN, Tseng CJ. Nifedipine, verapamil and diltiazem block shock-wave-induced rises in cytosolic calcium in MDCK cells. Chin J Physiol. 1998 Dec 31;41(4):181-8.
    265. Jan CR*, Ho CM, Wu SN, Tseng CJ. Mechanisms of rise and decay of ADP-evoked calcium signal in MDCK cells. Chin J Physiol. 1998 Jun 30;41(2):67-73.
    266. Jan CR*, Ho CM, Wu SN, Tseng CJ. Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells. Eur J Pharmacol. 1998 Aug 21;355(2-3):219-33.
    267. Jan CR*, Ho CM, Wu SN, Tseng CJ. The phospholipase C inhibitor U73122 increases cytosolic calcium in MDCK cells by activating calcium influx and releasing stored calcium. Life Sci. 1998;63(10):895-908.
    268. Wu SN, Yu HS, Jan CR, Li HF, Yu CL. Inhibitory effects of berberine on voltage- and calcium-activated potassium currents in human myeloma cells. Life Sci. 1998;62(25):2283-94.
    269. Jan CR*, Ho CM, Wu SN, Huang JK, Tseng CJ. La3+ inhibits UTP-induced Ca2+ mobilization in MDCK cells. Chin J Physiol. 1998;41(1):59-64.
    270. Jan CR*, Huang JK, Tseng CJ. High-energy shock waves alter cytosolic calcium mobilization in single MDCK cells. Nephron. 1998;78(2):187-94.
    271. Jan CR*, Ho CM, Wu SN, Huang JK, Tseng CJ. Mechanism of lanthanum inhibition of extracellular ATP-evoked calcium mobilization in MDCK cells. Life Sci. 1998;62(6):533-40.
    272. Wu SN, Jan CR, Li HF. Characteristics of store-operated Ca(2+)-permeable current in monocytic U937 cells. Chin J Physiol. 1997 Sep 30;40(3):115-20.
    273. Wu SN, Hwang TL, Jan CR, Tseng CJ. Ionic mechanisms of tetrandrine in cultured rat aortic smooth muscle cells. Eur J Pharmacol. 1997 May 30;327(2-3):233-8.
    274. Jan CR*, Chen WC, Lee YH, Huang JK, Ou HC, Tseng CJ. Allopurinol blocks shock-wave-induced rises in cytosolic calcium levels in MDCK cells. Urol Res. 1997;25(6):427-32.
    275. Chen WC, Jan CR*, Lee YH, Ou HC, Huang JK, Tseng CJ. A model for investigating effect of shock waves on intracellular calcium mobilization. Zhonghua Yi Xue Za Zhi (Taipei). 1996 Nov;58(5):341-7.
    276. Jan CR, Ribar TJ, Means AR, Augustine GJ. Alterations in calcium channel currents underlie defective insulin secretion in a transgenic Mouse. J Biol Chem. 1996 Jun 28;271(26):15478-85.
    277. Schneider AS, Jan CR. Na-Ca exchange in Ca2+ signaling and neurohormone secretion. Secretory vesicle contributions in adrenal chromaffin cells. Ann N Y Acad Sci. 1996 Apr 15;779:356-65.
    278. Ribar TJ, Jan CR, Augustine GJ, Means AR. Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic Mouse. J Biol Chem. 1995 Dec 1;270(48):28688-95.
    279. Jan CR, Schneider AS. Sodium-dependent calcium efflux from adrenal chromaffin cells following exocytosis. Possible role of secretory vesicle membranes. J Biol Chem. 1992 May 15;267(14):9695-700.
    280. Bigornia L, Allen CN, Jan CR, Lyon RA, Titeler M, Schneider AS. D2 dopamine receptors modulate calcium channel currents and catecholamine secretion in bovine adrenal chromaffin cells. J Pharmacol Exp Ther. 1990 Feb;252(2):586-92.
    281. Jan CR, Titeler M, Schneider AS. Identification of omega-conotoxin binding sites on adrenal medullary membranes: possibility of multiple calcium channels in chromaffin cells. J Neurochem. 1990 Jan;54(1):355-8.
    282. Sadzot B, Baraban JM, Glennon RA, Lyon RA, Leonhardt S, Jan CR, Titeler M. Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis. Psychopharmacology (Berl). 1989 98(4):495-9.
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