跳到主要內容區塊
:::

梁維哲 博士

Print
    資料來源：臨床醫學研究科       
    高雄榮民總醫院 教學研究部｜醫學研究科

    梁維哲 博士

    Wei-Zhe Liang, Ph.D.

    現任高雄榮民總醫院教學研究部高級助理研究員，研究聚焦於活性氧化物與毒物分析、毒理醫學、環境毒物、氧化壓力與毒殺路徑。

    Reactive Oxygen Species Analysis of Toxicants 毒理醫學 環境毒物 氧化壓力 毒殺路徑

    綜覽

    姓名 梁維哲
    Wei-Zhe Liang
    現職 高雄榮民總醫院
    教學研究部高級助理研究員
    研究室 活性氧化物與毒物分析研究室
    聯絡資訊 07-3422121 #71626 / 71627
    wzliang@vghks.gov.tw

    學歷與學術經歷

    最高學歷

    博士 高雄國立中山大學生物科學（系）所 博士畢

    學術經歷

    2020/03–迄今
    高雄榮民總醫院 教學研究部 高級助理研究員
    2019/09/01–迄今
    大仁科技大學藥學系暨製藥科技研究所 兼任副教授
    2013/04–2018/01
    東洋藥品工業股份有限公司 約聘研究員

    Office Hour 與 Lab Meeting

    Lab Meeting 每週一 9:00–10:00
    Office Hour 每週一、三 9:00–10:00

    證書會員

    • 教育部頒定副教授（副字第146791號）
    • TOEIC 高級檢定證照（證書字號10503726）
    • 特定化學作業主管安全衛生教育訓練結業證書（高雄市政府勞工局高市勞條字第10941872900號；證書字號110S01201030220；2021/02/03）
    • 有機溶劑作業主管安全衛生教育訓練結業證書（高雄市政府勞工局高市勞條字第10933440700號；證書字號109S04115010115；2020/06/16）
    • 經濟部智慧財產局之智慧財產培訓學院結業證書（智培智基證字第00023號；智培檢索證字第00017號）
    • 財團法人國家衛生研究院毒理學家認證課程證書
    • 成功大學生技藥物之開發管理培訓證書
    • 2020年高榮優良研究成果暨研究論文發表會座長
    • 中山大學生物科學系碩博士口試委員
    • 陽明大學微生物及免疫學所博士口試委員
    • 台灣毒理學學會永久會員（2017迄今）

    研究主題

    毒理醫學

    聚焦藥物、毒物與生物模型中之毒理反應、毒殺機制及細胞損傷路徑。

    環境毒物

    探討殺蟲劑、黴菌毒素、酚類化合物等環境相關毒物對細胞模型之影響。

    氧化壓力

    分析氧化壓力、活性氧化物生成與抗氧化物保護作用之相關機制。

    毒殺路徑

    研究鈣離子訊號、細胞凋亡與細胞毒性反應在毒物暴露下之調控機制。

    期刊論文

    Su CL, Chang PM, Liang WZ*. Exploring the Ca 2+ signaling and cytotoxicity induced by the alantolactone in breast cancer cells and its potential implications in treatment using the Ca 2+ chelating agent BAPTA-AM. Toxicol Res (Camb) 2025 Jun;14(3):tfaf044 (IF: 2.2; Toxicology ranking: 77/106)
    Chu CS, Chen YT, Sun WC, Liang WZ*. Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms. Mol Biol Rep 2025 Apr;52(1):391 (IF: 2.6; Biochemistry & Molecular Biology ranking: 204/313)
    Liang WZ#, Hsieh KW, Yang ZD, Sun GC. Induction of Ca 2+ signaling and cytotoxic responses of human lung fibroblasts upon an antihistamine drug oxatomide treatment and evaluating the protective effects of Ca 2+ chelating. Fundam Clin Pharmacol 2025 Feb;39(1):e13040 (IF: 2.1; Pharmacology & Pharmacy ranking: 210/354)
    Chu CS, Chen YT, Liang WZ*. Investigation of the mechanisms behind ochratoxin A-induced cytotoxicity in human astrocytes and the protective effects of N-acetylcysteine. J Appl Toxicol 2024 Sep;44(9):1454-1465 (IF: 2.7; Toxicology ranking: 56/106)
    Liang WZ#, Chia YY, Sun HJ, Sun GC. Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role. Toxicon 2024 May;243:107734 (IF: 2.6; Pharmacology & Pharmacy ranking: 173/354)
    Hsu SS, Lin YS, Chen HC, Liang WZ*. Involvement of oxidative stress-related apoptosis in chlorpyrifos-induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells. Environ Toxicol 2023 Sep;38(9):2143-2154 (IF: 4.4; Toxicology ranking: 18/106)
    Hsu SS, Lin YS, Chio LM, Liang WZ*. Evaluation of the mycotoxin patulin on cytotoxicity and oxidative stress in human glioblastoma cells and investigation of protective effect of the antioxidant N-acetylcysteine (NAC). Toxicon 2023 Jan;221:106957 (IF: 2.6; Pharmacology & Pharmacy ranking: 173/354)
    Chu CS, Lin YS, Liang WZ*. The Impact of the Antipsychotic Medication Chlorpromazine on Cytotoxicity through Ca 2+ Signaling Pathway in Glial Cell Models. Neurotox Res 2022 Jun;40(3):791-802 (IF: 2.9; Neurosciences ranking: 143/310)
    Lin YS, Chen WY, Liang WZ*. Investigation of Cytotoxicity and Oxidative Stress Induced by the Pyrethroid Bioallethrin in Human Glioblastoma Cells: The Protective Effect of Vitamin E (VE) and Its Underlying Mechanism. Chem Res Toxicol 2022 May;35(5):880-889 (IF: 3.7; Toxicology ranking: 28/106)
    Hsu SS, Lin YS, Liang WZ*. Inhibition of the pesticide rotenone-induced Ca 2+ signaling, cytotoxicity and oxidative stress in HCN-2 neuronal cells by the phenolic compound hydroxytyrosol. Pestic Biochem Physiol 2021 Nov;179:104979 (IF: 4.2; Entomology ranking: 7/109)
    Cheng KJ, Liang WZ*. Influence of a bearing-wastewater phenolic compound (3,4-dimethylphenol, 3,4-DMP) treatment on Ca 2+ homeostasis and its related cytotoxicity in human proximal renal tubular epithelial cells. Hum Exp Toxicol 2021 Nov;40(11):1899-1908 (IF: 2.7; Toxicology ranking: 56/106)
    Hsu SS, Lin YS, Liang WZ*. Investigation of cytotoxic effect of the bufanolide steroid compound cinobufagin and its related underlying mechanism in brain cell models. J Biochem Mol Toxicol 2021 Oct;35(10):e22862 (IF: 3.2; Toxicology ranking: 42/106)
    Shieh P, Hsu SS, Liang WZ*. Mechanisms underlying protective effects of vitamin E against mycotoxin deoxynivalenol-induced oxidative stress and its related cytotoxicity in primary human brain endothelial cells. Environ Toxicol 2021 Jul;36(7):1375-1388 (IF: 4.4; Toxicology ranking: 18/106)
    Hsu SS, Lin YS, Liang WZ*. Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA-AM in HCN-2 neuronal cells. Clin Exp Pharmacol Physiol 2021 May;48(5):801-810 (IF: 2.4; Physiology ranking: 42/85)
    Hsu SS, Liang WZ*. Cytotoxic Effects of Mesaconitine, the Aconitum Carmichaelii Debx Bioactive Compound, on HBEC-5i Human Brain Microvascular Endothelial Cells: Role of Ca 2+ Signaling-Mediated Pathway. Neurotox Res 2021 Apr;39(2):256-265 (IF: 2.9; Neurosciences ranking: 143/310)
    Sun GC, Liang WZ*. Mechanism of a methylxanthine drug theophylline-induced Ca 2+ signaling and cytotoxicity in AML12 mouse hepatocytes. Toxicol Res (Camb) 2020 Dec;9(6):790-797 (IF: 2.2; Toxicology ranking: 77/106)
    Hsu SS, Liang WZ*. Ca 2+ signaling as a mechanism of haloperidol-induced cytotoxicity in human astrocytes and assessing the protective role of a Ca 2+ chelator. Naunyn Schmiedebergs Arch Pharmacol 2020 Nov;393(11):2117-2127 (IF: 3.1; Pharmacology & Pharmacy ranking: 126/354)

    研討會論文

    Chang PM, Liang WZ*. Exploring the Ca 2+ signaling and cytotoxicity induced by the alantolactone in breast cancer cells and its potential implications in treatment using the Ca 2+ chelating agent BAPTA-AM. 2025/04/10-13。探討阿蘭託內酯在乳癌細胞中誘發的鈣離子訊號和細胞毒性及使用鈣離子螯合劑治療中的潛在意義。第8屆亞洲醫學檢驗科學學會暨第16屆亞太醫學檢驗科學國際研討會。
    Chu CS, Chen YT, Sun WC, Liang WZ*. Investigate the protective effects of eicosapentaenoic acid in human astrocytes of oxidative stress damage and explore its underlying mechanisms. 2025/04/10-13。研究二十碳五烯酸對人類星狀細胞氧化壓力損傷的保護作用並探討其潛在機制。第8屆亞洲醫學檢驗科學學會暨第16屆亞太醫學檢驗科學國際研討會。
    Chu CS, Chen WY, Liang WZ*. Exploration of beauvericin (BEA) on toxic effects and underlying toxic mechanisms in human brain models: the key role of reactive oxygen species (ROS) production and its signaling pathway. 2024/04/20-21。探索白殭菌素在人腦模型中的毒殺效應和潛在的毒理機制：活性氧化物的生成和其訊息傳遞路徑所扮演的關鍵角色。第15屆亞太醫學檢驗科學國際研討會。
    Chen YT, Chio LM, Hsu SS, Liang WZ*. The investigation of fipronil (FIP) on toxic mechanisms in brain models: the effect of oxidative stress-related signaling pathway. 2024/04/20-21。芬普尼在腦模型中毒理機制的調查：氧化壓力相關的訊息傳遞效應。第15屆亞太醫學檢驗科學國際研討會。
    Lin YS, Chen WY, Liang WZ*. Cytotoxicity, oxidative stress, and apoptosis induced by ochratoxin A in human glioblastoma cells: alleviating effect of the antioxidant N-acetylcysteine. 2023/04/22-23。赭曲黴毒素A誘發人膠質母細胞瘤的細胞毒性，氧化壓力和細胞凋亡：抗氧化劑N-乙酰半胱氨酸的改善作用。第14屆亞太醫學檢驗科學國際研討會。
    Chu CS, Chen WY, Liang WZ*. Protective effects of an eicosapentaenoic acid (omega-3 fatty acid) on H2O2-induced oxidative stress and cytotoxicity in human glioblastoma cell model. 2023/04/22-23。二十碳五烯酸在過氧化氫誘發人膠質母細胞瘤中氧化壓力和細胞毒性的保護作用。第14屆亞太醫學檢驗科學國際研討會。
    Liang WZ#, Chen HC, Chio LM, Hsu SS. Involvement of oxidative stress-related apoptosis in chlorpyrifos-induced cytotoxicity and the ameliorating potential of the antioxidant vitamin E in human glioblastoma cells. 2023/04/22-23。殺蟲劑毒死蜱在人腦瘤母細胞中誘發氧化壓力相關的細胞凋亡和抗氧化劑維生素 E 的改善潛力。第14屆亞太醫學檢驗科學國際研討會。
    Lin YS, Chen WY, Liang WZ*. Investigation of the pyrethroid insecticide bioallethrin that induced cytotoxicity and oxidative stress and preventive role of Vitamin E (VE) in DBTRG-05MG human glioblastoma cells. 2022/08/13-14。除蟲菊酯殺蟲劑生物丙烯菊酯在人膠質母細胞瘤細胞中誘發細胞毒性和氧化壓力的調查及探討維生素E的保護作用。第13屆亞太醫學檢驗科學國際研討會。
    Chu CS, Liang WZ*. The impact of the antipsychotic medication chlorpromazine on cytotoxicity through Ca 2+ signaling pathway in glial cell models. 2022/08/13-14。抗精神病藥物氯丙嗪對神經膠質細胞模型中鈣離子信號傳遞和細胞毒性的影響。第13屆亞太醫學檢驗科學國際研討會。
    Chen HC, Chen WY, Cheng JT, Liang WZ*. Investigation of the effect of the organophosphate insecticide chlorpyrifos on cytotoxicity and oxidative stress in human glioblastoma cell model. 2022/08/13-14。探討有機磷殺蟲藥陶斯松在腦瘤細胞模型中毒殺效應和氧化壓力的影響。第13屆亞太醫學檢驗科學國際研討會。
    Liang WZ#, Chio LM, Hsu SS. Mechanisms underlying protective effect of the antioxidant N-acetylcysteine (NAC) against the mycotoxin patulin-induced cytotoxicity in human glial cell model. 2022/08/13-14。探討抗氧化劑 N-乙酰半胱氨酸在人膠質細胞模型中展青黴素誘發細胞毒性的保護機制。第13屆亞太醫學檢驗科學國際研討會。
    Wen SC, Hsu SS, Yen HC, Liang WZ*. Protective Effects of Vitamin E (VE) against Mycotoxin Deoxynivalenol-Induced Cytotoxicity through Apoptosis in Normal Human Brain Endothelial Cells. 2021/04/10-11。維生素E在正常人腦內皮細胞中對黴菌毒素脫氧雪腐酚誘導細胞毒性的保護作用。第12屆亞太醫學檢驗科學國際研討會。
    Yen HC, Cheng KJ, Liang WZ*. Influence of A Bearing-Wastewater Phenolic Compound (3,4-Dimethylphenol, 3,4-DMP) Treatment on Ca 2+ Movement and Its Cytotoxicity in Kidney Cell Models. 2021/04/10-11。廢水酚類化合物（3,4-二甲基苯酚，3,4-DMP）對腎細胞模型中鈣離子移動和其細胞毒性的影響。第12屆亞太醫學檢驗科學國際研討會。
    聯絡資訊 聯絡人：唐維｜資料來源：醫學研究科｜聯絡資訊：twei@vghks.gov.tw
    twei@vghks.gov.tw
    :::