CYP酵素 |
Inhibitor (抑制劑) |
Inducer (誘導劑) |
Substrate |
1A2 |
Mexiletine, Fluvoxamine |
Omeprazole, Rifampin |
Acetaminophen, Amitriptyline, Clomipramine, Imipramine, Theophylline |
2C8-10 |
Cimetidine, Fluoxetine, Fluconazole, Omeprazole |
Phenobarbital, Rifampin |
Diclofenac, Diazepam, Ibuprofen, Losartan, Phenytoin, S-Warfarin |
2C18-19, Fluoxetine, Ketoconazole, Omeprazole |
|
Diazepam, Naproxen, Omeprazole, Propranolol |
2D6 |
Amiodarone, Cimetidine, Fluoxetine, Fluphenazine, Haloperidol, Quinidine, |
|
Clomipramine, Codeine, Dextromethophan, Fluoxetine, Haloperidol, Metoprolol, Mexiletine, Nortriptyline, Propafenone, Propoxyphene, Risperidone, Timolol, TCAs, Venlafaxine |
2E1 |
|
Ethanol, Isoniazid |
Acetaminophen, Chlorzoxazone, Halothane, Theophylline |
3A3 |
Cimetidine, Ranitidine |
|
Erythromycin, Midazolam |
3A4 |
Clarithromycin, Diltiazem, Erythromycin, Fluconazole, Fluoxetine, Grapefruit juice, Itraconazole Ketoconazole, Verapamil |
Barbiturates, Carbamazepine, Dexamethasone, Glucocorticoids, Macrolide antibiotics, Phenytoin, Rifampin |
Alprazolam, Amiodarone, Astemizole, Azithromycin, Carbamazepine, Clarithromycin, Cyclosporin, Diltiazem, Erythromycin, Hydrocortisone, Ketoconzole, Lidoxaine, Lovastatin, Midazolam, Nifedipine, Progesterone, Protease inhibitors, Simvastatin, Tacrolimus, Tamoxifen, Terfenadine, Triazolam, TCAs |
3A5 |
|
|
Lovastatin, Midazolam, Nifedipine |