洪 千 惠 主任
現任 :
高雄榮總皮膚科主任
高雄榮民總醫院皮膚科主治醫師
國立陽明大學醫學院醫學系皮膚學科副教授
國防醫學院醫學系臨床教授
臺灣研究皮膚科醫學會副祕書長
學歷 :
高雄醫學大學醫學研究所 醫學博士
美國國家衛生院心臟肺臟血液機構(NIH, NHLBI)博士後研究
美國國防醫學大學皮膚科博士後研究( Uniformed Services University of the Health Sciences, Department of Dermatology)
高雄醫學大學醫學系
高雄醫學大學臨床醫學研究所醫學碩士
美國約翰霍普金斯大學公共衛生研究院進修
國立中山大學高階經營碩士在職學分班EMBA進修
經歷 :
美國國家衛生院心臟肺臟血液機構(NIH, NHLBI)研究員
美國國防醫學大學皮膚科研究員( Uniformed Services University of the Health Sciences, Department of Dermatology)
台灣皮膚科學會專科醫師甄審委員
科技部生命科學研究發展司一般及產學研究計畫審查委員
科技部生命科學研究發展司審查研究計畫審查委員
科技部感官系統醫學學門審查研究計畫審查委員
科技部生科司藥學及中醫藥學門審查研究計畫審查委員
財團法人醫院評鑑暨醫療品質策進會醫療糾紛初鑑委員
財團法人醫院評鑑暨醫療品質策進會美容醫學品質認證審查委員
國民健康署諮詢委員
高雄榮民總醫院人體研究倫理審查委員會委員
高雄榮民總醫院研究倫理查核小組委員
醫策會醫學美容品質認證委員
高雄榮民總醫院兒少保護小組諮詢委員
高雄醫學大學附設醫院皮膚科(總)住院醫師
台灣大學醫學院附設醫院實習醫師
專長 :
免疫性皮膚病(異位性皮膚炎及乾癬等)與生物製劑治療
醫學美容皮膚學
皮膚腫瘤學
皮膚光電雷射治療
結節硬化症
主治項目 :
皮膚疾病
皮膚免疫性疾病(含乾癬及異位性皮膚炎等) 、黑色素細胞癌、皮膚腫瘤手術及治療、皮膚感染症(含黴菌感染、蜂窩組織炎等) 、尋常性痤瘡及痘疤治療、色素性皮膚疾病(含白斑及黑斑)、落髮與雄性禿、老年性皮膚疾病、小兒皮膚疾病、結節性硬化症、皮膚末梢循環障礙
醫學美容與雷射治療
除斑除刺青色素性雷射、除疤雷射、脈衝光除皺、光波拉皮、柔膚及淨膚雷射、肉毒桿菌素注射除皺、玻尿酸及膠原蛋白除皺及臉型雕塑、皮膚保養化妝品學
證照 ：
中華民國皮膚科專科醫師
臺灣皮膚科醫學會會員
台灣皮膚暨美容外科醫學會會員
臺灣研究皮膚科醫學會會員
美國研究皮膚科醫學會會員
歐洲研究皮膚科醫學會會員
台灣皮膚科醫學會 性傳染病推薦醫師
微整形注射證書
醫策會醫療糾紛初審鑑定醫師
實證健康照護教師證書
台灣醫學教育學會一般醫學師資(台師一般訓證字第002000號)
專案計畫 ：
全球性臨床試驗計畫主持人
執行科技部多年期計畫主持人
異位性皮膚炎、乾癬、黑色素細胞癌、皮秒雷射應用等
論著 :
Chien-Hui Hong, Ji-Chen Ho, Chih-Hung Lee. Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates p38, Facilitates Epithelial-Mesenchymal Transformation, and Mediates Experimental Melanoma Metastasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2020; 140(7):1355-1363 (SCI). (Impact factor: 7.143;Rank: 3.68%)第一作者/通訊作者作者
Szu-Yun Fang, Chien-Hui Hong. Eruptive tumor of the follicular infundibulum with unusual clinical presentation: A case report and literature review. Dermatologica Sinica 2020; 38(1):39-42 (SCI). (Impact factor: 0.921;Rank: 90.44%)第二作者(通訊)作者
Hong, Chien-Hui; Lin, Shang-Hung; Clausen, Bjorn E.; Lee, Chih-Hung. Selective AhR knockout in langerin-expressing cells abates Langerhans cells and polarizes Th2/Tr1 in epicutaneous protein sensitization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2020; 117(23):12980-12990 (SCI). (Impact factor: 9.412;Rank: 10.56%)第一作者/通訊作者作者
Chih-Hung Lee, Ji-Chen Ho, Chien-Hui Hong. Targeting steroid receptor RNA activator (SRA), a long non-coding RNA, enhances melanogenesis through activation of TRP1 and inhibition of p38 phosphorylation. PLoS One 2020; : (SCI). (Impact factor: 2.74;Rank: 37.32%)單一作者(通訊)作者
CHIEN-HUI HONG、SHANG-HUNG LIN、CHIH-HUNG LEE. CCL21 Induces mTOR-dependent MALAT1 Expression, Leading to Cell Migration in Cutaneous T-Cell Lymphoma. IN VIVO 2019; 33:793-800 (SCI). (Impact factor: 1.541;Rank: 79.50%)第一作者/通訊作者作者
Y.-S. Sheen , K.-T. Tan, K.-P. Tse, Y.-H. Liao , M.-H. Lin, J.-S. Chen, J.-Y. Liau, Y.-J. Tseng,C.-H. Lee, C.-H. Hong, J.-B. Liao, H.-T. Chang, and C.-Y. Chu. Genetic Alterations in Primary Melanoma in Taiwan. BRITISH JOURNAL OF DERMATOLOGY 2019; 182(5):1205-1213. (SCI). (Impact factor: 7;Rank: 5.15%)第十作者作者
Yu-An Wei1、Wan-Chi Chuang、Chien-Hui Hong. Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor-a inhibitor. INTERNATIONAL JOURNAL OF DERMATOLOGY 2018; 57(7):869-871 (SCI). (Impact factor: 2.067;Rank: 52.21%)第一作者/通訊作者(通訊)作者
Chao-Chun Yang、Tak-Wah Wong、Chih-Hung Lee、Chien-Hui Hong、Chung-Hsing Chang、Feng-Jie Lai、Shang-Hung Lin、Ching-Chi Chi、Tzu-Kai Lin、Hsi Yen、Chin-Han Wu、Hamm-Ming Sheu、Cheng-Che E. Lan. Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial. JOURNAL OF DERMATOLOGICAL SCIENCE 2018; 90(3):295-302 (SCI). (Impact factor: 3.681;Rank: 16.91%)第四作者以後作者
Sebastian Yu、Hung-Pin Tu、Chu-Ling Yu、Chih-Hung Lee、Chien-Hui Hong*. Is psoriasis an independent risk factor of renal disease?A nationwide retrospective cohort study from 1996 to 2010. Dermatologica Sinica 2017; 35:78-84 (SCI). (Impact factor: 0.921;Rank: 90.44%)單一作者(通訊)作者
Ying-Yi Lu, Chieh-Hsin Wu, Chun-Ching Lu, Chien-Hui Hong. Hyperpigmentation as a peculiar presentation of mycosis fungoides. ANAIS BRASILEIROS DE DERMATOLOGIA 2017; 92(5 Suppl 1):92-94 (SCI). (Impact factor: 1.121;Rank: 83.09%)單一作者(通訊)作者
Kuo FR, Chin YY, Lee CH, Chiu YH, Hong CH, Lee KL, Ho WH, Lee CH.. Web-based Learning System for Developing and Assessing Clinical Diagnostic Skills for Dermatology Residency Program. EDUCATIONAL TECHNOLOGY & SOCIETY 2016; 19(3):194-206 (SSCI). (Impact factor: 2.086;Rank: 31.37%)第四作者以後作者
Hong CH, Tu HP, Lin JR , and Lee CH.. An estimation of the incidence of tuberous sclerosis complex by a nationwide retrospective cohort study from 1997 to 2010. BRITISH JOURNAL OF DERMATOLOGY 2016; 174(6):1282-9 (SCI). (Impact factor: 7;Rank: 5.15%)第一作者/通訊作者作者
Lee, C.H., Hong, C.H., Liao, W.T., Yu, H.S.. Differential immunological effects of infrared irradiation and its associated heat in vivo. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2016; 155:98—103 (SCI). (Impact factor: 4.383;Rank: 17.61%)第二作者作者
Hong CH, Lee CH, Yu HS, Huang SK. Benzopyrene, a major polyaromatic hydrocarbon in smoke fume, mobilizes Langerhans cells and polarizes Th2/17 responses in epicutaneous protein sensitization through the aryl hydrocarbon receptor. INTERNATIONAL IMMUNOPHARMACOLOGY 2016; 36:111-117 (SCI). (Impact factor: 3.943;Rank: 23.06%)第一作者/通訊作者作者
Chou TC, Tsai KB, Wu CY, Hong CH, Lee CH. Presence of the Merkel cell polyomavirus in Merkel cell carcinoma combined with squamous cell carcinoma in a patient with chronic arsenism. CLINICAL AND EXPERIMENTAL DERMATOLOGY 2016; 41(8):902-905 (SCI). (Impact factor: 1.977;Rank: 55.15%)第四作者以後作者
Yu HS, Tu HP, Hong CH, Lee CH. Lifetime Increased Risk of Adult Onset Atopic Dermatitis in Adolescent and Adult Patients with Food Allergy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2016; 18(1):pii: E42. doi: 10.3390/ijms18010042 (SCI). (Impact factor: 4.556;Rank: 24.75%)第三作者作者
Chih-Hung Lee, Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Li-Fang Wang. Differential activation behavior of dermal dendritic cells underlies the strain-specific Th1 responses to single epicutaneous immunization. JOURNAL OF DERMATOLOGICAL SCIENCE 2016; 84(3):248-257 (SCI). (Impact factor: 3.681;Rank: 16.91%)第四作者以後作者
Chih‐Hung Lee, Jau‐Shiuh Chen, Hsien‐Ching Chiu, Chien‐Hui Hong, Ching‐Yi Liu, Yng‐Cun Ta, Bjőrn E. Clausen, Ji‐Chen Ho, Li‐Fang Wang. Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization. EXPERIMENTAL DERMATOLOGY 2015; 24(1):67-9 (SCI). (Impact factor: 3.368;Rank: 21.32%)第四作者以後作者
HONG CH, LEE CH, CHEN GS, YU HS. STAT3-dependent VEGF production from keratinocytes abrogates dendritic cell activation and migration by arsenic: a plausible regional mechanism of immunosuppression in arsenical cancers. CHEMICO-BIOLOGICAL INTERACTIONS 2015; 227(2015): 96—103 (SCI). (Impact factor: 3.723;Rank: 16.85%)第一作者/通訊作者作者
Hong CH, Chang KL, Wang HJ, Yu HS, Lee CH. IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: a plausible mechanism of IL-9R in atopic dermatitis. JOURNAL OF DERMATOLOGICAL SCIENCE 2015; 78(3):206-214 (SCI). (Impact factor: 3.681;Rank: 16.91%)第一作者/通訊作者作者
Stephen Chu-Sung Hu, Chi-Ling Lin, Chien-Hui Hong, Hsin-Su Yu, Gwo-Shing Chen, Chih-Hung Lee. CCR7 expression correlates with subcutaneous involvement in mycosis fungoides skin lesions and promotes migration of mycosis fungoides cells (MyLa) through mTOR activation. JOURNAL OF DERMATOLOGICAL SCIENCE 2014; 74(1):31-38 (SCI). (Impact factor: 3.681;Rank: 16.91%)第三作者作者
Ying-Yi Lu, Jia-Bin Liao, Chieh-Shan Wu, Chien-Hui Hong. Pityriasis lichenoids chronica as a paraneoplastic dermatosis for primary splenic diffuse large B cell lymphoma. Indian Journal of Hematology and Blood Transfusion 2014; Suppl(1):246-249 (SCI). (Impact factor: 1.615;Rank: 80.92%)單一作者(通訊)作者
Yi-Chien Yang, Hung-Pin Tu, Chien-Hui Hong, Wei-Chao Chang, Hung-Chun Fu, Ji-Chen Ho, Wei-Pin Chang, Hung-Yi Chuang, Chih-Hung Lee. Female gender and acne disease are jointly and independently associated with the risk of major depression and suicide: a national population-based study. Biomed Research International 2014; doi: 10.1155/2014/504279(doi: 10.1155/2014/504279):1-7 (SCI). (Impact factor: 2.276;Rank: 58.65%)第三作者作者
7. Fu-Nan Cho, Tsung-Hsien Chang, Chih-Wen Shu, Ming-Chin Ko, Shuen-Kuei Liao, Kang-Hsi Wu, Ming-Sun Yu, Shyh-Jer Lin, Ying-Chung Hong, Chien-Hsun Chen, Chien-Hui Hung, Yu- Hsiang Chang.. Enhanced Cytotoxicity of Natural Killer Cells following the Acquisition of Chimeric Antigen Receptors through Trogocytos. PLoS One 2014; 9(10):e-109352 (SCI). (Impact factor: 2.74;Rank: 37.32%)第四作者以後作者
Lu YY, Wu CS, Hong CH*. Primary cutaneous cryptococcosis in an immunocompetent man: A case report. Dermatologica Sinica 2013; 31:90-93 (SCI). (Impact factor: 0.921;Rank: 90.44%)第一作者/通訊作者作者
Chih-Hung Lee, Shi-Bei Wu, Chien-Hui Hong, Hsin-Su Yu, Yau-Huei Wei. Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2013; 14(3):6414-35 (SCI). (Impact factor: 4.556;Rank: 24.75%)第三作者作者
Chih-Hung Lee, Shi-Bei Wu, Chien-Hui Hong, Gwo-Shin Chen, Yau-Huei Wei, Hsin-Su Yu. Involvement of mtDNA Damage Elicited by Oxidative Stress in the Arsenical Skin Cancers. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2013; 133(7):1890-900 (SCI). (Impact factor: 7.143;Rank: 3.68%)第三作者作者
Hong CH, Yu HS, Ko YC, Chang WC, Chuang HY, Chen GS, Lee CH.. Functional Regulation of Interleukin-31 Production by its Genetic Polymorphism in Patients with Extrinsic Atopic Dermatitis. ACTA DERMATO-VENEREOLOGICA 2012; 92(4):430-2 (SCI). (Impact factor: 4.016;Rank: 9.56%)第一作者/通訊作者作者
Lee CH, Hong CH, Yu CL, Wang LF, Clausen BE, Liao WT, Huang SK, Chen GS, Yu HS.. Arsenic mobilizes Langerhans cell migration and induces Th1 response in epicutaneous protein sensitization via CCL21: a plausible cause of decreased Langerhans cells in arsenic-induced intraepithelial carcinoma. BIOCHEMICAL PHARMACOLOGY 2012; 83(9):1290-9 (SCI). (Impact factor: 4.96;Rank: 9.78%)第二作者作者
Lee CH, Hong CH, Yu WT, Chuang HY, Huang SK, Chen GS, Yoshioka T, Sakata M, Liao WT, Ko YC, Yu HS.. Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY 2012; 167(4):794-803 (SCI). (Impact factor: 7;Rank: 5.15%)第二作者作者
Lee CH, Hong CH, Chen YT, Chen YC, Shen MR.. TGF-beta1 increases cell rigidity by enhancing expression of smooth muscle actin: keloid-derived fibroblasts as a model for cellular mechanics. JOURNAL OF DERMATOLOGICAL SCIENCE 2012; 67(3):173-80 (SCI). (Impact factor: 3.681;Rank: 16.91%)第二作者作者
Chang WC, Lee CH, Hirota T, Wang LF, Doi S, Miyatake A, Enomoto T, Tomita K, Sakashita M, Yamada T, Fujieda S, Ebe K, Saeki H, Takeuchi S, Furue M, Chen WC, Chiu YC, Chang WP, Hong CH, Hsi E, Juo SH, Yu HS, Nakamura Y, Tamari M.. ORAI1 genetic polymorphisms associated with the susceptibility of atopic dermatitis in Japanese and Taiwanese populations. PLoS One 2012; 7(1):e29387 (SCI). (Impact factor: 2.74;Rank: 37.32%)第四作者以後作者
Seibert D, Hong CH, Takeuchi F, Olsen C, Hathaway O, Moss J, Darling TN.. Recognition of Tuberous Sclerosis in Adults: Delayed Presentation with Life-Threatening Consequences. ANNALS OF INTERNAL MEDICINE 2011; 154(12):806-14 (SCI). (Impact factor: 21.317;Rank: 3.33%)第二作者作者
Lee CH, Chuang HY, Hong CH, Huang SK, Chang YC, Ko YC, Yu HS.. Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis. BRITISH JOURNAL OF DERMATOLOGY 2011; 164(3):483-9 (SCI). (Impact factor: 7;Rank: 5.15%)第三作者作者
Lee CH, Wu SB, Hong CH, Liao WT, Wu CY, Chen GS, Wei YH, Yu HS.. Aberrant Cell Proliferation by Enhanced Mitochondrial Biogenesis via mtTFA in Arsenical Skin Cancers. AMERICAN JOURNAL OF PATHOLOGY 2011; 178(5):2066-76 (SCI). (Impact factor: 3.491;Rank: 23.72%)第三作者作者
Lee CH, Hong CH, Yu HS, Chen GS, Yang KC.. TGF-beta enhances MMP-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex. BRITISH JOURNAL OF DERMATOLOGY 2010; 163(6):1238-44 (SCI). (Impact factor: 7;Rank: 5.15%)第二作者作者
Aldrich CS, Hong CH, Groves L, Olsen C, Moss J, Darling TN.. Acral Lesions in Tuberous Sclerosis Complex: Insights into Pathogenesis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2010; 63(2):244-51 (SCI). (Impact factor: 8.277;Rank: 0.74%)第一作者/通訊作者作者
Avila NA, Dwyer AJ, Rabel A, Darling T, Hong CH, Moss J.. CT of sclerotic bone lesions: imaging features differentiating tuberous sclerosis complex with lymphangioleiomyomatosis from sporadic lymphangioleiomymatosis. RADIOLOGY 2010; 254(3):851-7 (SCI). (Impact factor: 7.931;Rank: 1.87%)第四作者以後作者
Liao WT, Yu HS, Arbiser JL, Hong CH, Govindarajan B, Chai CY, Shan WJ, Lin YF, Chen GS, Lee CH.. Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids. EXPERIMENTAL DERMATOLOGY 2010; 19(8):e142-50 (SCI). (Impact factor: 3.368;Rank: 21.32%)第四作者以後作者
Hong CH, Darling TN, Lee CH. The Prevalence of Tuberous Sclerosis Complex in Taiwan: A national population-based study. NEUROEPIDEMIOLOGY 2009; 33(4):335-341 (SCI). (Impact factor: 2.186;Rank: 45.34%)第一作者/通訊作者作者
Lee CH, Hu WP, Hong CH, Yu HS, Liao WT, Chen CY, Chen YL, Chen BH, Chen GS, Wang JJ.. Pyrrolo [2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. CHEMICO-BIOLOGICAL INTERACTIONS 2009; 180(3):360-7 (SCI). (Impact factor: 3.723;Rank: 16.85%)第三作者作者
Hong CH, Lee CH, Chang LW, Chiou MH, Hsieh MC, Kao YH, Yu HS.. Anti-endothelial cell IgG from patients with chronic arsenic poisoning induces endothelial proliferation and VEGF-dependent angiogenesis. MICROVASCULAR RESEARCH 2008; 76(3):194-201 (SCI). (Impact factor: 2.73;Rank: 43.85%)第一作者/通訊作者作者
Sparling JD, Hong CH, Brahim JS, Moss J, Darling TN.. Oral Findings in 58 Adults with Tuberous Sclerosis Complex. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2007; 56(5):786-790 (SCI). (Impact factor: 8.277;Rank: 0.74%)第二作者作者
Hong CH, Hou MF, Chen GS.. Microcystic Adnexal Carcinoma of the Nipple. Dermatologica Sinica 2004; 22(3):153-158 (SCI). (Impact factor: 0.921;Rank: 90.44%)第一作者/通訊作者作者
Hong CH, Chen GS, Cheng ST. Multiple asymptomatic papules on the trunk. Dermatologica Sinica 2004; 22(3):270-271 (SCI). (Impact factor: 0.921;Rank: 90.44%)第一作者/通訊作者作者
Hong CH, Chen GS, Yu HS, Chuang HY.. Occupational Radiodermatitis: an Accidental Overexposure to Ir192 Gamma Rays. Dermatologica Sinica 2002; 20(2):128-135 (SCI). (Impact factor: 0.921;Rank: 90.44%)第一作者/通訊作者作者