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醫師介紹
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    陳文誌 CHEN Wen-Chi
    陳文誌 CHEN Wen-Chi
    看診科別
    主治項目
    • 肝臟疾病
    • 胃腸膽道疾病
    專長
    • 慢性B型與C型肝炎
    • 肝硬化
    • 胃食道靜脈瘤出血
    • 腹水
    • 肝性腦病變
    • 肝癌
    現職
    • 高雄榮總 胃腸肝膽科主治醫師 (2001~ )
    • 高雄榮總 胃腸肝膽科肝病中心主任 (2011~ )
    • 國立陽明大學兼任助理教授(2016~ )
    • 高雄榮總 胃腸肝膽科 科主任(2018~ )
    學歷
    • 台灣大學醫學系醫學士
    經歷
    • 台北榮民總醫院住院醫師 (1995~1998)
    • 台北榮民總醫院胃腸科總醫師 (1998~2000)
    • 高雄榮民總醫院胃腸科總醫師 (2000~2001)
    • 美國哈佛大學附屬麻州總醫院博士後研究(2009-2010)
    證照
    • 中華民國內科醫學會專科醫師
    • 中華民國消化系醫學會消化內科專科醫師
    • 中華民國消化內視鏡醫學會專科醫師
    • 中華民國醫用超音波醫學會專科醫師
    專案計畫
    • C型肝炎病毒引起肝纖維化之病生理機轉
    論著
    • 1.Hung HC, Chen WC, Chao Y, Hou MC, Lin HC, Chang FY, Lee SD. Klebsiella pneumoniae panophthalmitis: a possible complication of endoscopic variceal injection sclerotherapy. Am J Gastroenterol 1998;93:2603-4. (SCI)
    • 2.Chen WC, Hou MC, Lin HC, Chang FY, Lee SD. An endoscopic injection with N-butyl-2-cyanoacrylate used for colonic variceal bleeding: a case report and review of the literature. Am J Gastroenterol 2000;95:540-2. (SCI)
    • 3.Chen WC, Hou MC, Lin HC, Chang FY, Lee SD. Symptomatic esophageal stricture after endoscopic variceal ligation — success of endoscopic balloon dilation. Chin Med J (Taipei) 2000;63:144-7.
    • 4.Chen WC, Hou MC, Lin HC, Lee FY, Yeh YY, Chang FY, Lee SD. Feasibility and potential benefit of maintenance endoscopic variceal ligation in patients with unresectable hepatocellular carcinoma and acute esophageal variceal hemorrhage: a controlled trial. Gastrointest Endosc 2001;54:18-23. (SCI)
    • 5.Chen WC, Hou MC, Lin HC, Yu KW, Lee FY, Chang FY, Lee SD. Bacteremia after endoscopic injection of N-butyl-2-cyanoacrylate for gastric variceal bleeding. Gastrointest Endosc 2001;54;214-8. (SCI)
    • 6.Chen WC, Hou MC, Tsay SH, Lo SS, Lin HC, Chang FY, Lee SD. Gastric perforation after endoscopic ligation for gastric varices. Gastrointest Endosc 2001;54:99-101. (SCI)
    • 7.Hou MC, Chen WC, Lin HC, Lee FY, Chang FY, Lee SD. A new “sandwich”method of combined endoscopic variceal ligation and sclerotherapy versus ligation alone in the treatment of esophageal variceal bleeding: a randomized trial. Gastrointest Endosc 2001;53:572-8. (SCI)
    • 8.Lo GH, Chen WC, Chen MH, Hsu PI, Lin CK, Tsai WL, Lai KH. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding. Gastroenterology. 2002;123:728-34. (SCI)
    • 9.Lo GH, Chen WC, Chen MH, Lin CP, Lo CC, Hsu PI, Cheng JS, Lai KH. Endoscopic ligation vs. nadolol in the prevention of first variceal bleeding in patients with cirrhosis. Gastrointest Endosc 2004;59:333-8. (SCI)
    • 10.Lo GH, Chen WC, Chen MH, Tsai WL, Chan HH, Cheng LC, Hsu PI, Lai KH. The Characteristics and prognosis of Patients Presenting with Active Bleeding Esophageal Varices at Endoscopy. Gastrointest Endosc 2004. (SCI)
    • 11.Chen WC, Lo GH, Lai KH, Cheng JS, Hsu PI, Lin CK. Development of Hepatocellular Carcinoma after Successful Management of Esophageal Variceal Bleeding. J Chin Med Assoc 2004;67:557-564.
    • 12.Hsu PI, Lai KH, Lin CK, Chen WC, Yu HC, Cheng JS, Tsay FW, Wu CJ, Lo CC, Tseng HH, Yamaoka Yoshio, Chen JL , Lo GH. A Prospective Randomized Trial of Esomeprazole- versus Pantoprazole-Based Triple Therapy for Helicobacter pylori Eradication. Am J Gastroenterol 2005;100:2387-2392.
    • 13.Chen WC, Lo GH, Tsai WL, HSU PI, Lin CK, Lai KH. Emergency endoscopic variceal ligation versus somatostatin for acute esophageal variceal bleeding. J Chin Med Assoc 2006;69:60-67.
    • 14.Wang HM, Lo GH, Chen WC, Tsai WL, Chan HH, Cheng LC, Hsu PI, Lai KH. Comparison of endoscopic variceal ligation and Nadolol plus Isosorbide-5-mononitrate in the prevention of first variceal bleeding in cirrhotic patients. J Chin Med Assoc 2006;69(10):453-460.
    • 15.Lo GH, Liang HL, Chen WC, Chen MH, Lai KH , Hsu PI, Lin CK, Chan HH, Pan HB. A prospective,randomized controlled trial of transjugular intrahepatic portosystemic shunt versus cyanoacrylate injection in the prevention of gastric variceal rebleeding. Endoscopy 2007;39:679-685. (SCI)
    • 16.Lo GH, Chen WC, Lin CK, Tsai WL, Chan HH, Chen TA, Yu HC, Hsu PI, Lai KH. Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding. Hepatology 2008;48:580-7. (SCI)
    • 17.Lo GH, Chen WC, Wang HM, Lin CK, Chan HH, Tsai WL, Cheng LC, Yu HC, Tsay FW. Low-dose terlipressin plus banding ligation versus low-dose terlipressin alone in the prevention of very early rebleeding of oesophageal varices. Gut 2009;58:1275-80. (SCI)
    • 18.Lo GH, Chen WC, Chan HH, Tsai WL, Hsu PI, Lin CK, Chen TA, Lai KH. A randomized, controlled trial of banding ligation plus drug therapy versus drug therapy alone in the prevention of esophageal variceal rebleeding. J Gastroenterol Hepatol 2009;24:982-7. (SCI)
    • 19.Lo GH, Chen WC, Wang HM, Lee CC. Controlled trial of ligation plus nadolol versus nadolol alone for the prevention of first variceal bleeding. Hepatology 2010;52:230-7. (SCI)
    • 20.Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J Biol Chem. 2011;286(4):2665-74. (SCI)
    • 21.Zhang L, Jilg N, Shao RX, Lin W, Fusco DN, Zhao H, Goto K, Peng LF, Chen WC, Chung RT. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. J Hepatol. 2011 Aug;55(2):289-98. doi: 10.1016/j.jhep.2010.11.019. (SCI)
    • 22.Liu CP, Chen WC, Lai KH, Mar GY, Lin SY, Ger LP, Hsu PI. Esomeprazole alone compared with esomeprazole plus aspirin for the treatment of aspirin-related peptic ulcers. Am J Gastroenterol 2012;107:1022-9. (SCI)
    • 23.Lo GH, Chen WC, Wang HM, Yu HC. A randomized, controlled trial of carvedilol vs. nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding. J Gastroenterol Hepatol. 2012;11:1681-7. (SCI)
    • 24.Wang HM, Lo GH, Chen WC, Hsu PI, Yu HC, Lin CK, Chan HH, Tsai WL, Tsay FW, Liu TP, Wang EM, Lai KH. Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis. J Dig Dis 2012;13(8):430-8. (SCI)
    • 25.Chen PH*, Chen WC*, Hou MC, Liu TT, Chang CJ, Liao WC, Su CW, Wang HM, Lin HC, Lee FY, Lee SD. Delayed endoscopy increases re-bleeding and mortality in patients with hematemesis and active esophageal variceal bleeding: A cohort study. J Hepatol 2012;57(6):1207-13. (SCI) *equal contribution
    • 26.Kao SS, Chen WC, Hsu PI, Lai KH, Yu HC, Cheng HH, Peng NJ, Lin CK, Chan HH, Tsai WL, Wang HM, Tsai TJ, Lin KH, Tsay FW. 7-Day Nonbismuth-Containing Concomitant Therapy Achieves a High Eradication Rate for Helicobacter pylori in Taiwan. Gastroenterol Res Pract. 2012;2012:463985. (SCI)
    • 27.Kao SS, Chen WC, Hsu PI, Chuah SK, Lu CL, Lai KH, Tsai FW, Chang CC, Tai WC. The Frequencies of Gastroesophageal and Extragastroesophageal Symptoms in Patients with Mild Erosive Esophagitis, Severe Erosive Esophagitis, and Barrett's Esophagus in Taiwan. Gastroenterol Res Pract. 2013;2013:480325. doi: 10.1155/2013/480325. (SCI)
    • 28.Shao RX, Zhang L, Hong Z, Goto K, Cheng D, Chen WC, Jilg N, Kumthip K, Fusco DN, Peng LF, Chung RT. SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication. Antiviral Res. 2013 Feb;97(2):101-7. doi: 10.1016/j.antiviral.2012.12.001. (SCI)
    • 29.Hsu PI, Chen WC, Tsay FW, Shih CA, Kao SS, Wang HM, Yu HC, Lai KH, Tseng HH, Peng NJ Chen A, Kuo CH, Wu DC. Ten-day Quadruple therapy comprising proton-pump inhibitor, bismuth, tetracycline, and levofloxacin achieves a high eradication rate for Helicobacter pylori infection after failure of sequential therapy. Helicobacter 2014;19(1):74-9. (SCI)
    • 30.Chen WC, Chen YH, Hsu PI, Tsay FW, Chan HH, Cheng JS, Lai KH. Gastrointestinal hemorrhage in warfarin anticoagulated patients: incidence, risk factor, management and outcome. Biomed Research International. 2014;2014：463767. (SCI)
    • 31.Hsu PI, Wu DC, Chen WC, Tseng HH, Yu HC, Wang HM, Kao SS, Lai KH, Chen A, Tsay FW. Comparison of 7-day triple, 10-day sequential and 7-day concomitant therapies for Helicobacter pylori infection - a randomized controlled trial. Antimicrob Agents Chemother. 2014;58(10):5936-42. (SCI)
    • 32.Chen WC, Li YD, Hsu PI, Tsay FW, Chan HH, Tsai WL, Cheng JS, Lai KH. Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users - A retrospective cohort study. Biomed Research International. 2014;2014：693567.(SCI)
    • 33.Chen WC, Chiang PH, Tsay FW, Yu HC, Chan HH, Tsai WL, Wang HM, Cheng JS, Lai KH, Hsu PI. A comparison of entecavir and lamivudine in the prophylaxis of hepatitis B virus reactivation in solid tumor patients undergoing cytotoxic chemotherapy. Plos One. 2015;10(6):e0131545. (SCI)
    • 34.Wang FW, Chuang HY, Tu MS, King TM, Wang JH, Hsu CW, Hsu PI, Chen WC*. Prevalence and risk factors of asymptomatic colorectal diverticulosis in Taiwan. BMC Gastroenterology. 2015;15:40. *correspondence
    • 35.Shih CA, Chen WC, Yu HC, Cheng JS, Lai KH, Hsu JT, Chen HC, Hsu PI. Risk of severe acute exacerbation of chronic HBV infection cancer patients who underwent chemotherapy and did not receive anti-viral prophylaxis. Plos One 2015;10:e0132426. (SCI)
    • 36.Hsu PI, Kao SS, Wu DC, Chen WC, Peng NJ, Yu HC, Wang HM, Lai KH, Cheng JS, Chen A, Chuah SK, Tsay FW; Taiwan Acid-Related Disease Study Group. A Randomized Controlled Study Comparing Reverse Hybrid Therapy and Standard Triple Therapy for Helicobacter pylori Infection. Medicine (Baltimore). 2015 94:e2104. (SCI)
    • 37.Hsu PI, Wu DC, Tsay FW, Cheng JS, Liu CP, Lai KH, Chen WC, Wang HM, Tsai TJ, Tsai KW, Kao SS. Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial. Am J Gastroenterol. 2017;112:282-289. (SCI)
    • 38.Chen WC, Lin KH, Huang YT, Tsai TJ, Sun WC, Chuah SK, Wu DC, Hsu PI. The risk of lower gastrointestinal bleeding in low-dose aspirin users. Aliment Pharmacol Ther. 2017;45:1542-1550. (SCI)
    • 39.Chen WC, Lin KH, Huang YT, Tsai TJ, Sun WC, Chuah SK, Wu DC, Hsu PI. Editorial: lower gastrointestinal bleeding and low-dose aspirin-authors' reply. Aliment Pharmacol Ther. 2017;46:200-201. (SCI)
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