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楊明慧 博士

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    資料來源：臨床醫學研究科       

    學歷：

    博士 Texas Christian University, Department of Chemistry

    碩士 University of Texas at Dallas, Department of Chemistry

    學術經歷：

    1. 高雄榮民總醫院教學研究部高級助理研究員 (2020迄今)

    2. 國家衛生研究院國家蚊媒傳染病防治研究中心博士後研究員

    3. 高雄醫學大學傳染病與癌症研究中心博士後研究員/研究助理教授

    4. 國立雲林科技大學化學工程與材料工程系博士後研究員

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    1. M. H. Yang, Y. M. A. Chen, S. C. Tu, P. L. Chi, K. P. Chuang, C. C. Chang, C. H. Lee, Y. L. Chen, C. H. Lee, C. H. Yuan, Y. C. Tyan*. (2021) Utilizing an animal model to identify brain neurodegeneration-related biomarkers in aging. Int J Mol Sci. 22(6), 3278. (IF= 5.923, 67/298, 22.48%, Biochemistry & molecular biology)
    2. R. Kant, M. H. Yang (co-first author), C. H. Tseng, C. H. Yen, W. Y. Li, Y. C. Tyan, M. Chen, C. C. Tzeng, W. C. Chen, K.T. You, W. C, Wang, Y. L. Chen* and Y. M. A. Chen*. (2021) Discovery of an orally efficacious Myc inhibitor for liver cancer using Gnmt-based high throughput screening system and structure-activity relationship analysis. J. Med. Chem. 64(13), 8992–9009. (IF= 7.446, 3/63, 4.76%, Chemistry, medicinal)
    3. T. C. Ho, Y. M. A Chen, H. P. Chan, C. C. Chang, K. P. Chuang, C. H. Lee, C. H. Yuan, Y. C. Tyan, M. H. Yang*. (2021) The Effects of Heterologous Immunization with Prime-Boost COVID-19 Vaccination against SARS-CoV-2. Vaccines, 9(10), 1163. (IF= 4.422, 63/140, 45.0%, Medicine, research & experimental)
    4. M. H. Yang, M. Chen, H. H. Mo, W. C. Tsai, Y. C. Chang, C. C. Chang, K. C. Chen, H. Y. Wu, C. H. Yuan, C. H. Lee, Y. M. A Chen*, Y. C. Tyan*. Utilizing experimental mouse model to identify effectors of hepatocellular carcinoma induced by HBx antigen, Cancers, 12(2). pii: E409, 2020 (IF=6.126, 37/244, 15.16 %, Oncology).
    5. Y. C. Tyan, M. H. Yang, C. C. Chang, T. W. Chung*. Biocompatibility of Materials for Biomedical Engineering. Biomimicked Biomaterials. Advances in Experimental Medicine and Biology, vol 1250, pp 125-140, 2020 (IF=2.450, 36/93, 38.71%, Biology).
    6. M. H. Yang+, S. H. Chen, K. C. Chen+, H. P. You, H. Y. Wu, Y. M. Chen, Y. F. Huang, M. Y. Huang, C. H. Yuan, P. C. Lin, Y. C. Tyan*. Quantitative analysis of progesterone using isotope dilution matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for radioimmunoassay. Clinica Chimica Acta, in press, 2020 (IF=2.735, 8/29, 27.59 %, Medical laboratory technology).
    7. M. H. Yang, C. C. Liao, J. H. Hung, X .L. Lai, C. H. Yen* and Y. M. A Chen*. Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene.Journal of Food and Drug Analysis, 27(2), 603-9, 2019 (IF=4.176, 13/135, 9.63 %, Food science & technology).
    8. M. Chen+, M. H. Yang+(co-first author), M. M. Chang, Y. C. Tyan, Y. M. A Chen*. Tumor suppressor gene Glycine N-methyltransferase and its potential as a target for anti-cancer drug development. Toxicology and Applied Pharmacology, 378,114607, 2019 (IF= 3.585, 21/93, 22.58%, Toxicology).
    9. M. H. Yang, S. C. Chen, Y. F. Lin, Y. C. Lee, M. Y. Huang, K. C. Chen, H. Y. Wu, P .C. Lin, I. Gozes* and Y .C. Tyan*. Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease. Journal of Food and Drug Analysis, 27(2), 551-64, 2019 (IF=4.176, 13/135, 9.63 %, Food science & technology).
    10. M. H. Yang, C. H. Yen,Y. F. Chen,C. C. Fang, C. H. Li,K. J. Lee, Y. H. Lin, C. H. Weng,T. T. Liu, S. F. Huang, B. T. TehandY. M. Arthur Chen*. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. Scientific Reports, 9(1), 2552, 2019 (IF=4.011, 15/69, 21.74%, multidisciplinary sciences).
    11. M. H. Yang, W. J. Chen, Y. S. Fu, Bi. Huang, W. C. Tsai, Y. M. A Chen, P. C. Lin, C. H. Yuan and Y. C. Tyan*. Utilizing glycine N-methyltransferasegene knockout mice as a model for identification of missing proteins in hepatocellular carcinoma. Oncotarget, 9(1), 442-452, 2018 (IF=5.168, 44/217, 20.28%, Oncology).
    12. S. C. Chen+, M. H. Yang+(co-first author), T. W. Chung, T. S. Jhuang, J. D. Yang, K. C. Chen, W. J. Chen, Y. F. Huang, S. B. Jong, W. C. Tsai, P. C. Lin and Y. C. Tyan*. Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International, Volume 2017, Article ID 4051763, 8 pages, 2017 (IF=2.583, 66/161, 40.99%, Biotechnolohy & applied microbiology).
    13. M. H. Yang+, K. C. Chen+, P. W. Chiang, W. J. Chen, P. Y. Chu, S. Chen, Y. S. Lu, C. H. Yuan, M. C. Wang, C. Y. Lin, Y. F. Huang, S. B. Jong, P. C. Lin, T. W. Chung and Y. C. Tyan*. Proteomic profiling of neuroblastoma cells adhesion on hyaluronic acid-based surface for neural tissue engineering. BioMed Research International, Volume 2016, Article ID 1917394, 13 pages, 2016 (IF=2.476, 67/160, 41.88%, Biotechnolohy & applied microbiology).
    14. C. H. Tsai+, M. H. Yang+(co-first author), A. Hung, S. C. Wu, W. C. Chiu, M. F. Hou, Y. C. Tyan, Y. M.  Wang, S. S. Yuan*. Id1 is a downstream effector for arsenic-promoted angiogenesis via PI3K/Akt, NF-κB and NOS signaling. Toxicology Research, 5,151-159, 2016 (IF=1.969, 61/92, 67.39%, Toxicology).
    15. M. H. Yang, T. W. Chung, Y. S. Lu, Y. L. Chen, W. C. Tsai, S. B. Jong, S. S. Yuan, P. C. Liao, P. C. Lin, Y. C. Tyan*. Activation of the Ubiquitin Proteasome Pathway by Silk Fibroin Modified Chitosan Nanoparticles in Hepatic Cancer Cells. Int. J. Mol. Sci., 16, 1657-1676, 2015. (IF=3.257, 52/163, 31.90% Chemistry, multidisciplinary).
    16. M. H. Yang, S. S. F. Yuan, T. W. Chung, S. B. Jong, C. Y. Lu, W. C. Tsai, W. C. Chen, P. C. Lin, P. W. Chiang, Y. C. Tyan. Characterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials. BioMed Research International. 2014:209469, 2014. (IF=2.706, 53/165, 32.12%, Biotechnology & applied microbiology).
    17. M. H. Yang, S. S. Yuan, Y. F. Huang, P. C. Lin, C. Y. Lu, T. W. Chung and Y. C. Tyan. A proteomic view to characterize the effect of chitosan nanoparticle to hepatic cells – Is chitosan nanoparticle an enhancer of PI3K/AKT1/mTOR pathway? BioMed Research International. 2014:789591, 2014. (IF=2.706, 53/165, 32.12%, Biotechnology & applied microbiology).
    18. M. H. Yang, H. Y. Wang, C. Y. Lu, W. C. Tsai, P. C. Lin, S. B. Su and Y. C. Tyan*. Proteomic profiling for peritoneal dialysate: Differential protein expression in diabetes mellitus. BioMed Research International. 2013: 642964, 2013. (IF=2.88, 50/160, 31.25%, Biotechnology & applied microbiology).
    19. Y. C. Tyan+,*, M. H. Yang+(co-first author), T. W. Chung, C. Y. Lu, W. C. Tsai, S. B. Jong “Assessing human urinary proteome using a mass spectrometry-based profiling system combined with magnetic nanoparticles.” Clinica Chimica Acta, 420, 54-61, 2013 (SCI, IF=2.85, Rank=6/32,  19%, MEDICAL LABORATORY TECHNOLOGY).
    20. Y. C. Tyan*, S. B. Jong, M. H. Yang (co-first), T. L. Wu, T. W. Chung, P. C. Liao, C. Y. Lin, Y. F. Huang, “Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine.” Clinica Chimica Acta, 420, 99-103, 2013 (SCI, IF=2.85, Rank=6/32,  19%, MEDICAL LABORATORY TECHNOLOGY).
    21. M. H. Yang, A. Dibas, Y. C. Tyan*, “Changes in retinal aquaporin-9 (AQP9) expression in glaucoma.” Bioscience Reports, 33 (2), 379-385, 2013. (SCI, IF= 1.876, Rank=141/185, 76%, CELL BIOLOGY).
    22. M. H. Yang, S. B. Jong, C. Y. Lu, Y. F. Lin, P. W. Chiang, Y. C. Tyan*, T. W. Chung*. “Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing mass spectrometry-based profiling system: over-expression of CD36, CD44, CDK9, and PP2A” Analyst, 137, 4921-4933, 2012. (Journal’s cover story, hot article)  (SCI, IF=4.230, Rank=8/73, 11%,  CHEMISTRY, ANALYTICAL).
    23. M. H. Yang, Y. H. Yang, C. Y. Lu, S. B. Jong, L.J. Chen, Y. F. Lin, S. J. Wu, P. Y. Chu, T. W. Chung, Y. C. Tyan*, “Activity-dependent neuroprotector homeobox protein: a candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease” Journal of Proteomics, 75, 3617-29, 2012. (SCI, IF=4.878, Rank=12/72, 17%, BIOCHEMICAL RESEARCH METHODS)
    24. Y. C. Tyan*, M. H. Yang (co-first author), C. J. Chen, S. B. Jong, W. C. Chen, Y. H. Yang, T. W. Chung, P. C. Liao, “Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma” Rapid Communications in Mass Spectrometry, 25, 2851-62, 2011. (SCI, IF=2.846, Rank=19/73, 20.4%, CHEMISTRY, ANALYTICAL).
    25. M. H. Yang, P. Y. Chu, C. J. Chen, W. C. Chen, T. W. Chung, L. B. Tan, W. C. Kan, H. Y. Wang, S. B. Su, Y. C. Tyan*, “Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis.” Biochemical and Biophysical Research Communications, 411, 714-720, 2011. (SCI, IF=2.595, Rank=38/73, 52.05%, BIOPHYSICS).
    26. M. H. Yang, R. R. Krishnamoorthy, S. B. Jong, P. Y. Chu, Y. H. Yang, W. C. Chen, C. J. Chen, A. Dibas, T. Yorio, T. W. Chung*, Y. C. Tyan*, “Protein profiling of human non-pigmented ciliary epithelium cell secretome - the differentiation factors characterization for retinal ganglion cell-line.” Journal of Biomedicine and Biotechnology, 2011, 1-28, 2011. (SCI, IF=1.230, Rank=111/160, 69.3%, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
    27. Y. C. Tyan*, M. H. Yang (co-first author), T. W. Chung, W. C. Chen, M. C. Wang, Y. L. Chen, J. L. Huang, Y. F. Huang, S. B. Jong*, “Characterization of surface modification on self-assembled monolayer-based piezoelectric crystal immunosensor for the quantification of serum alpha - fetoprotein.” Journal of Materials Science: Materials in Medicine, 22, 1383-1391, 2011. (SCI, IF=2.325, Rank=20/70, 28.57%, ENGINEERING, BIOMEDICAL).
    28. M. H. Yang, L. H. Lo, Y. H. Chen, J. Shiea*, P. C. Wu, Y. C. Tyan, Y. J. Jong, “Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.” Rapid Communications in Mass Spectrometry, 23, 3220-3226, 2009. (SCI, IF=2.846, Rank=19/73, CHEMISTRY, ANALYTICAL).
    29. Y. C. Tyan, M. H. Yang, S. B. Jong, C. K. Wang, J. Shiea, “Melamine contamination.” Analytical and Bioanalytical Chemistry, 395, 729-735, 2009. (SCI, IF=3.841, Ranking: 9/73, CHEMISTRY, ANALYTICAL).
    30. A. Dibas*, M. H. Yang, S. He, J. Bobich, T. Yorio, “Changes in ocular aquaporin-4 (AQP4) expression following retinal injury.” Molecular Vision 14:1770-1783, 2008. (SCI, IF=2.511, Ranking=14/56, OPHTHALMOLOGY).
    31. P. P Lin, M. H. Yang, P. C. Liao, H. Y. Wu, L. W. Chang, H. T. Tsai, Y. C. Tyan*, “Proteomic analysis of proteins associated with tt-DDE induced toxicity in BEAS-2B cells.” Biochemical and Biophysical Research Communications 376: 519-524, 2008. (SCI, IF=2.595, Rank=38/73, BIOPHYSICS).
    32. Y. W. Liu, M. H. Yang, P. Y. Liu, C. H. Lee, P. C. Liao, Y. C. Tyan*, “Proteomic analysis of pericardial effusion: characteristic of tuberculosis-related proteins.” Proteomics Clin. Appl. 2: 458-466, 2008. (SCI, IF=1.514, Ranking=49/65, Biochemical research methods).
    33. M. H. Yang, Y. C. Tyan*, S. B. Jong, Y. F. Huang, P. C. Liao, M. C. Wang, “Identification of human hepatocellular carcinoma-related proteins by proteomic approaches” Analytical & Bioanalytical Chemistry 388: 637-643, 2007. (SCI, IF=3.841, Ranking=9/73, CHEMISTRY, ANALYTICAL).
    34. Y. C. Tyan*, M. H. Yang, P. C. Liao, J.D. Liao, S. B. Jong, C. Y. Liu, M. C. Wang, M. Grunze, “MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolayers: A preliminary application for protein sample analysis” International Journal of Mass Spectrometry 262: 67-72, 2007. (SCI, IF=2.337, Ranking=10/39, SPECTROSCOPY).
    35. A. Dibas*, M. H. Yang, J. Bobich, T. Yorio, “Stress-induced changes in neuronal Aquaporin-9 (AQP9) in a retinal ganglion cell-line” Pharmacological Research 55: 378-384, 2007. (SCI, IF=3.612, Ranking=56/252, PHARMACOLOGY & PHARMACY).
    36. M. H. Yang and M. C. Biewer*, “Monitoring surface reactions optically in a self-assembled monolayer with a photochromic core” Tetrahedron Letters 46:349-351, 2005. (SCI, IF=2.618, Ranking=20/56, CHEMISTRY, ORGANIC).
    37. M. H. Yang, J. D. Liao, S. B. Jong, P. C. Liao, C. Y. Liu, M. C. Wang, M. Grunze, Y. C. Tyan*, “Identification of human plasma proteins by trypsin immobilized digestion chip and electrospray ionization tandem mass spectrometry” Journal of Medical and Biological Engineering 25: 81-86, 2005. (SCI, IF=0.42, Ranking=63/70, ENGINEERING, BIOMEDICAL).
    1. The roles of PREX2 and its interacting proteins in liver cancer. The Asia Pacific Society for Biology and Medical Sciences 2019 Annual Meeting. (2019 July/ Sapporo, Japan)
    2. Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma. 2018. The 2nd Israel Taiwan International Medical Conference. (2018 Nov/ Kaohsiung, Taiwan)
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