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曾清俊 教授

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    中樞心臟血管研究室研究員 
    曾清俊 (Ching-Jiunn Tseng)

    現職:

    高雄榮民總醫院 教學研究部 醫師暨研究員 (2006/08迄今) 
    國立陽明大學 臨床醫學研究所 兼任教授 (2006/07迄今) 
    國立中山大學 生物醫學研究所 合聘教授 (1999/08迄今) 
    私立高雄醫學大學 藥理研究所 兼任教授 (1995/07迄今) 
    國防醫學院 藥理學科 合聘教授 (1993/08迄今)

    經歷:

    高雄榮民總醫院教學研究部 醫師暨研究員兼主任 (1998/04至2006/07) 
    高雄榮民總醫院醫學研究科 醫師暨研究員兼主任 (1994/04至1998/03)

    Art editor Img

    • 1974-1981 國防醫學院醫學士
    • 1984-1988 美國凡登堡大學醫學院藥理學系哲學博士
    • 醫師執照
    1. Outstanding Research Award, 2005 (行政院退輔會)
    2. Outstanding Research Award, 2006 (行政院退輔會)
    3. Outstanding Research Award, 2008.08.27 (高雄榮民總醫院)
    4. Outstanding Research Award, 2008.09.01 (行政院退輔會)
    5. Outstanding Research Award, 2010 (行政院退輔會)
    6. Outstanding Research Award, 2011 (行政院退輔會)
    7. Outstanding Research Award, 2012 (行政院退輔會)
    8. Outstanding Research Award, 2015 (行政院退輔會)
    1. Society for Neuroscience, U.S.A.
    2. American Heart Association, U.S.A.
    3. American Federation for Clinical Research, U.S.A.
    4. Taiwan Pharmacological Society-Taipei (常務理事)
    5. Chinese Physiological Society (理事)
    6. Chinese Basic Neuroscience Society (理事)
    1. 基礎醫學
    2. 臨床醫學
    3. 藥理學
    4. 生理學
    1. 無菌操作台
    2. 倒立式螢光顯微鏡
    3. 正立式螢光顯微鏡
    4. 無菌培養箱
    5. 冷凍切片機
    6. 立體定位儀
    7. 解剖顯微鏡
    8. 超音波檢測儀
    9. 一氧化氮檢測器
    10. -20℃冰箱
    11. -80℃冰箱
    12. 切片機
    13. 非侵入性大鼠尾壓檢測器
    1. The Chinese Journal of Physiology (Editorial Board)
    2. Journal of the Chinese Medical Association (2001.8-2007.7 Editor)
    3. Journal of the Biomedical Science (Reviewer)
    4. Journal of Pharmacology and Experimental Therapeutics (Reviewer)
    5. Hypertension (Reviewer)
    6. European Journal of Pharmacology (Reviewer)
    7. Journal of Cardiovascular Pharmacology (Reviewer)
    8. Biochem Pharmacology (Reviewer)
    9. Life Science (Reviewer)
    10. Journal of Autonomic Pharmacology (Reviewer)
    11. Journal of Applied Physiology (Reviewer)
    12. Drug Therapy
    13. Critical Care Medicine (Reviewer)
    1. The 25th Joint Annual Conference of Biomedical Science. Molecular Network of Blood Pressure Control in the Brain Stem Nuclei. National Defense Medical Center, Taipei, Taiwan, 2010.
    2. The 7th FAOPS congress. Neuronal insulin resistance of nucleus tractus solitarii induced by ROS and p38 causes hypertension in fructose-fed rats. NTUH International Convention Center, Taipei, Taiwan, 2011.
    3. International Conference of Physiological Sciences. Nitric oxide in the nucleus tractus solitarII: A pivotal role of central blood pressure modulation. Suzhou, China. 2012
    4. 國科會生物處記者會(2013年3月20日)。題目：高血壓治療之心(新)的方向，中樞一氧化氮的貢獻。
    5. 高雄榮總記者會(2013年5月1日)。題目：腸病毒71型重症之轉譯醫學。
    6. 第九屆海峽兩岸心血管研討會(The 9th Scientific Conference on Cardiovascular Sciences Across the Strait, Tainan, Taiwan, 2013年8月16-20日)邀請演講。題目：The Central Regulatory Mechanism in Nucleus Tractus Solitarii：A New Insight and Concept for Neurogenic Hypertension.
    7. 中國醫藥大學現代生物醫學講座(2013年12月20日)邀請演講。題目：Pharmacology of the Nucleus Tractus Solitarii: A Pivotal Role of Central Blood Pressure Modulation.

    一. Representative publications:

    *: corresponding author . **: shared corresponding author
    1. Chen HH, Lu PJ, Chen BR, Hsiao M, Ho WY*, Tseng CJ*. Heme Oxygenase-1 Ameliorates Kidney Ischemia-reperfusion Injury in Mice through Extracellular Signal-regulated Kinase 1/2-Enhanced Tubular Epithelium Proliferation. Biochimica Et Biophysica Acta-Molecular Basis Of Disease, 2015, In press.
    2. Cheng PW, Chen YY, Cheng WH, Lu PJ, Chen HH, Chen BR, Yeh TC, Sun GC, Hsiao M, Tseng CJ. (2015) Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes. Apr 16.
    3. Sun G.C., Ho W.Y., Chen B.R., Cheng P.W., Cheng W.H., Hsu M.C., Yeh T.C., Hsiao M, Lu P.J., Tseng C.J.* GPCR dimerization in brainstem nuclei contributes to the development of hypertension. Br J Pharmacol. 2015 May;172(10):2507-18.
    4. Yeh T.C., Liu C.P., Cheng W.H., Chen B.R., Lu P.J., Cheng P.W., Ho W.Y., Sun G.C., Liou J.C., Tseng C.J.* Caffeine Intake Improves Fructose-Induced Hypertension and Insulin Resistance by Enhancing Central Insulin Signaling. Hypertension. 2014 Mar;63(3):535-41.
    5. Lu W.H., Lu P.J., Wu Y.S., Ho W.Y., Cheng P.W., Lai C.C., Hsiao M, Wang J.S., Tseng CJ*. Diifferent Impacts of Alpha and Beta Blockers in Neurogenic Hypertension Produced by Brainstem Lesions in Rat. Anesthesiology. 2014 May;120(5):1192-204
    6. Cheng P.W., Ho W.Y., Su Y.T., Lu P.J., Chen B.Z., Cheng W.H., Lu W.H., Sun G.C., Yeh T.C., Hsiao M, Tseng C.J*. Resveratrol Decrease Fructose-Induced Oxidative Stress Mediated by NADPH Oxidase via an AMPK-Dependent Mechanism. British Journal of Pharmacology, 2014; 171(11), 2739-50.
    7. Cheng PW, Kang BH, Lu PJ, Lin SS, Ho WY, Chen HH, Hong LZ, Wu YS, Hsiao M, Tseng CJ. (2014, Sep). Involvement of two distinct signalling pathways in IGF-1-mediated central control of hypotensive effects in normotensive and hypertensive rats. Acta physiologica, 212(1):28-38.
    8. Lai CC, Fang HC, Tsai HL, Mar GY, Tseng CJ, Liu CP, Liou JC. (2014, Jul). Translesional pressure ratio predicts technical outcome and patency in angioplasty on outflow stenosis of hemodialysis graft. J Vasc Access, 15(4), 264-71.
    9. Tung-Chen Yeh, Chun-Peng Liu, Ching-Jiunn Tseng, Pa-Rum Can and Jau-Cheng Liou (2014, Jul). Left Ventricular Pseudoaneurysm Caused by Infective Endocarditis. Acta Cardiol Sin, 30, 346349.
    10. Chi-Cheng Lai, Hua-Chang Fang, Ching-Jiunn Tseng, Chun-Peng Liu, Guang-Yuan Mar (2014, Apr). Percutaneous angioplasty using a paclitaxel-coated balloon improves target lesion restenosis on inflow lesions of autogenous radiocephalic fistulas: a pilot study. Journal of Vascular and Interventional Radiology, 25(4), 535-41.Lu WH, Hsieh KS, Lu PJ, Wu YS, Ho WY, Lai CC, Wang JS, Ger LP, Hsiao M, Tseng CJ*. Hexamethonium reverses the lethal cardiopulmonary damages in a rat model of brainstem lesions mimicking fatal enterovirus 71 encephalitis. Critical Care Medicine. 2013 May;41(5):1276-85.
    11. Cheng W.H., Ho W.Y., Chang C.F., Lu P.J., Cheng P.W., Yeh T.C., Hong L.Z., Sun G.C., Hsiao M, Tseng CJ. Simvastatin induces a central hypotensive effect via Ras-mediated signalling to cause eNOS up-regulation. Br J Pharmacol. 2013 Oct;170(4):847-58.
    12. Lai CC, Fang HC, Tsai HL, Mar GY, Tseng CJ, Liu CP, Liou JC. Post-angioplasty far infrared radiation therapy improves 1-year angioplasty-free hemodialysis access patency of recurrent obstructive lesions. Eur J Vasc Endovasc Surg. 2013 Dec;46(6):726-32
    13. Lai CC, Fang HC, Tsai HL, Mar GY, Tseng CJ, Liu CP, Liou JC. Translesional pressure ratio predicts technical outcome and patency in angioplasty on outflow stenosis of hemodialysis graft. J Vasc Access. 2013 Oct 31;0(0):0.
    14. Lai CC, Fang HC, Lin CH, Mar GY, Tseng CJ, Liu CP. Distal radial artery pressures predict angiographic result and short-term patency outcome in hemodialysis patients with juxta-anastomotic inflow stenosis of radiocephalic fistula undergoing transradial angioplasty. Ther Apher Dial. 2013 Jun;17(3):311-8.
    15. Cheng WH, Lu PJ, Hsiao M, Hsiao CH, Ho WY, Cheng PW, Lin CT, Hong LZ, Tseng CJ*. Renin Activates PI3K-Akt-eNOS Signaling Through the AT1 Receptor and Mas Receptor to Modulate Central Blood Pressure Control in the Nucleus Tractus Solitarii. British Journal of Pharmacology. 2012,166:2024-35.
    16. Cheng PW, Wu ATH, Lu PJ, Yang YC, Ho WY, Lin HC, Hsiao M, Tseng CJ*. Modulation of Central Control of Hypotensive Effects by Neuropeptide Y is Mediated through RSK Induced Activation of Endothelial Nitric Oxide Synthase. British Journal of Pharmacology. 2012,167:1148-60.
    17. Hong L.Z., Cheng P.W., Cheng W. H., Chen S.R., Wang L.L., Tseng C.J.*, Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects. Chinese J Physiology.2012; 55(5): 337-345.
    18. Hong LZ, Chan YC, Wang MF, Wang JY, Hung SW, Tsai CI, Tseng CJ*. Modulation of baroreflex function by rosiglitazone in prediabetic hyperglycemic rats. Physiol Res. 2012 Dec 14;61(5):443-52. Epub 2012 Aug 8.
    19. Lu C.C., Li M.H., Lin T.C., Chen T.L., Chen R.M., Tung C.S., Tseng C.J., Ho S.T.. Water ingestion reduces skin blood flow through sympathetic vasoconstriction. Clinical Autonomic Research. 2012.
    20. Cheng P.W., Lu P.J., Chen S.R., Ho W.Y., Cheng W.H., Hong L.Z., Yeh T.C., Sun G.C., Wang L.L., Hsiao M., Tseng C.J.*. Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects. British Journal of Pharmacology, 2011;163(6):1203-13.
    21. Lai C.C., Chung H.M., Tsai H.L., Mar G.Y., Tseng C.J., Liu C.P. Intragraft pressures predict outcomes in hemodialysis patients with graft outflow lesions undergoing percutaneous transluminal angioplasty. Catheterization and Cardiovascular Interventions, 2010;76(2):206-11.
    22. Cheng W.H., Lu P.J., Ho W.Y., Tung C.S., Cheng P.W., Hsiao M., Tseng C.J.*. Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1/2-RSK signaling pathway to modulate central control of blood pressure. Circulation Research, 2010;106(4):788-95.
    23. Liu Y.P., Lin P.J., Tseng C.J., Wan F.J., and Tung C.S.. Role of dopaminergic DAD1 and DAD2 receptors in the sensitization of amphetamine-suppressed schedule-induced polydipsia in rats. Chinese Journal of Physiology, 2009;31;52(5):280-8.
    24. Chiang H.T., Cheng W.H., Lu P.J., Huang H.N., Lo W.C., Tseng Y.C., Wang J.L., Hsiao M., Tseng C.J.*. Neuronal nitric oxide synthase activation is involved in insulin-mediated cardiovascular effects in the nucleus tractus solitarii of rats. Neuroscience, 2009;159(2):727-34.
    25. Leung K.W., Tsai C.H., Hsiao M., Tseng C.J., Ger L.P., Lee K.H., Lu P.J.. Pin1 overexpression is associated with poor differentiation and survival in oral squamous cell carcinoma. Oncology Reports, 2009;21(4):1097-104.
    26. Lu C.C., Li M.H., Ho S.T., Lu C.L., Lin J.C., Lin T.C., Tung C.S., Tseng C.J.*. Glucose reduces the effect of water to promote orthostatic tolerance. American Journal of Hypertension, 2008;21(11):1177-82.
    27. Hsiao M., Lu P.J., Huang H.N., Lo W.C., Ho W.Y., Lai T.C., Chiang H.T., Tseng C.J.* Defective phosphatidylinositol 3-kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats.. Hypertension Research, 2008;31(6):1209-18.
    28. Hsu P.I., Huang M.S., Chen H.C., Hsu P.N., Lai T.C., Wang J.L., Lo G.H., Lai K.H., Tseng C.J., Hsiao M. The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer. Journal of Surgical Oncology, 2008;97(7):609-14.
    29. Ho W.Y., Lu P.J., Hsiao M., Hwang H.R., Tseng Y.C., Yen M.H., Tseng C.J.* Adenosine modulates cardiovascular functions through activation of extracellular signal-regulated kinases 1 and 2 and endothelial nitric oxide synthase in the nucleus tractus solitarii of rats. Circulation, 2008;117(6):773-80.
    30. Tai, M.H., Weng, W.T., Lo, W.C., Chan, J.Y., Lin, C.J., Tseng C.J.* Role of nitric oxide in alpha-melanocyte-stimulating hormone-induced hypotension in the nucleus tractus solitarii of the spontaneously hypertensive rats. J Pharmacol Exp Ther. 2007 321:455-61.
    31. Lo, W.C., Lu, P.J., Ho, W.Y., Hsiao, M., Tseng C.J.* Induction of heme oxygenase-1 is involved in CO mediated central cardiovascular regulation. J Pharmacol Exp Ther.2006, 318: 8-16.
    32. Huang, H.N., Lo, W.C., Lin, C.H., Lu, P.J., Hsiao, M., Tseng C.J.* In-situ AKT phosphorylation in the nucleus tractus solitarii is involved in the central cantrol of blood pressure and heart rate. Circulation. 2004; 110:2476-2483.
    33. Lo, W.C., Hsiao, M., Tung, C.S., Tseng C.J.* The cardiovascular effects of nitric oxide and carbon monoxide in the nucleus tractus solitarii of rats. J. Hypertension. 2004; 22: 1183-1190.
    34. Lin, C.H., Lo, W.C., Hsiao, M., Tung, C.S., Tseng C.J.* Interactions of carbon monoxide and metabotropic glutamate receptor groups in the nucleus tractus solitarii of rats. J Pharmacol Exp Ther. 2004; 308:1213-8.
    35. Tai, M.H., Hsiao, M., Lo, W.C., Wang, F.S., Liu, G.S., Chan, J.Y.H., Howng, S.L., Tseng C.J.*. Gene delivery of eNOS into nucleus tractus solitarii modulates cardiovascular functions in spontaneously hypertension rats. Am. J. Hypertension. 2004; 17:63-70.

    二. 研討會論文 Conference Abstracts

    1. Tseng, C.J., Lin, S.S., Lo, W.C., Lu, P.J. The cardiovascular effects of insulin-like growth factor-1 in the nucleus solitarii of rats. The 15th World Congress of Pharmacology, Acta Pharmacologica Sinica, Supplement 1; P127, 2006, Beijing, China.
    2. Tseng C. J., Lo, W. C., LU, P. J., Hsiao, M., (2005). Induction of heme oxygenase-1 is involved in CO-mediated central cardiovascular regulation. Society for Neuroscience, 35TH Annual Meeting. EE15, 522.11, Washinton D. C., USA.
    3. Tseng, C.J., Tai, M.H., Hsiao, M., Chan, J.Y.H. Gene delivery of eNOS into nucleus tractus solitarii modulates cardiovascular functions in spontaneously hypertensive rats. Keystone Symposia: Molecular biology of cardiac disease. P69, 2004, Keystone, USA.
    4. Chen, E.L., Hsiao, M.H., Tseng, C.J. ANX7 is a bio-marker in glioma progression. The Eighteenth Joint Annual Conference of Biomedical Sciences. O49, 2003.
    5. Huang, S.N., Lo, W.C., Lin, C.H., Hsiao, M.H., Tseng, C.J. Determinations of insulin signaling defects in NTS neurons of spontaneous hypertensive rat. The Eighteenth Joint Annual Conference of Biomedical Sciences. P363, 2003.
    6. Lin, H.C., Wan, F.J., Tung, C.S., Tseng, C.J. The role of calcium signaling in amphetamine-induced neurotoxicity in primary cortical culture. The Eighteenth Joint Annual Conference of Biomedical Sciences. P205, 2003.
    7. Tseng, C.J., Huang, S.N., Lo, W.C., Lin, C.H., Hsiao, M.H. Insulin molecular signaling is defective in NTS neurons of adult spontaneous hypertensive rat. Society for Neuroscience, 33RD Annual Meeting. G68, 922.1, 2003, New Orleans. USA.
    8. Lo, W.C., Tseng, C.J. Integration of nitric oxide and carbon monoxide in the nucleus tractus solitarii of rats. XIVth World Congress of Pharmacology. A433, 2002, San Francisco, USA.
    9. Cheng P.W., Lin S.S., Tseng C.J. Growth Factor Receptor-Bound Protein 2 Plays an Important Role in IGF-1 Mediated Central Control of Hypotensive Effects. Society for Neuroscience, 41RD Annual Meeting. NOV 12; P: 40.08/ D68, 2011, Washington.
    10. Chen H.H., Ho W.Y., Tseng C.J. Heme Oxygenase-1 Enhances Tubular Recovery from Kidney Ischemia-Reperfusion Injury through Activating Extracellular Signal-Regulated Kinases 1 and 2 in mice. Society for Neuroscience, 41RD Annual Meeting. NOV 14; P: 393.16/ VV93, 2011, Washington.
    11. Cheng W.-H., Yeh T.-C., Chen B.-R., Tseng C.-J. Caffeine Consumption Reduces Insulin Resistance and Blood Pressure in Fructose-Induced Hypertension. Society for Neuroscience, 41RD Annual Meeting. NOV 13; P: 283.12/QQ7, 2011, Washington. USA.
    12. Cheng W.H., Hsiao C.H., Tseng C.J. Renin activates PI3K-Akt-eNOS signaling through AT1 receptor to modulate central cardiovascular control in the nucleus tractus solitarii. Society for Neuroscience, 40RD Annual Meeting. NOV 17; P: 794.1/CCC3, 2010, San Diego. USA.
    13. Cheng P.W, Chen S.R, Tseng C.J, Lin H.C. Nicotinic acetylcholine receptor is involved in Ca2+-calmodulin-endothelial nitric oxide synthase pathway to modulate depressor effects in the nucleus tractus solitarii. Society for Neuroscience, 40RD Annual Meeting. NOV 13; P: 38.9, 2010, San Diego. USA.
    14. Ho, W.Y., Lu, P.J., Chen Y.K., Tseng, C.J. Adenosine modulates cardiovascular functions through activating ERK1/2 and endothelial nitric oxide synthase in the nucleus tractus solitarii of rats. XLIV ERA-EDTA Congress, Nephrology Dialysis Transplantation, Supplement 6; vi38: FP065, 2007, Barcelona, Spain.
    15. Tseng, C.J., Yang, Y.C., Ho, W.Y., Ger, L.P., Lu, P.J. Molecular signaling mechanisms of neuropeptide Y in central cardiovascular control in the nucleus tractus solitarii on rats. XLIV ERA-EDTA Congress, Nephrology Dialysis Transplantation, Supplement 6; vi38: FP063, 2007, Barcelona, Spain.
    16. Tseng, C.J., Yang, Y.C., Ger, L.P., Lu, P.J. Molecular signaling mechanisms of neuropeptide Y in the nucleus tractus solitarii on rats. 7th IBRO World Congress of Neuroscience, P142: POS-FRI-181, 2007, Australia.
    17. Ger, L.P., Weng, W.T., Lo, W.C., Tai, M.H., Tseng, C.J. Cardiovascular effects of alfa-Melanocyte-stimulating Hormone in the nucleus tractus solitarii of rats. The 15th World Congress of Pharmacology, Acta Pharmacologica Sinica, Supplement 1; P127, 2006, Beijing, China.
    18. Tseng, C.J., Lo, W.C. Cardiovascular effects of carbon monoxide and adenosine in the nucleus tractus solitarii of rats. XIVth World Congress of Pharmacology. A434, 2002, San Francisco, USA.
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